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Yannis Mantas Paulus, MD

Assistant of Ophthalmology
Main Location

The Johns Hopkins Hospital

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  • Assistant of Ophthalmology

Centers & Institutes

  • Wilmer Eye Institute Research


Diabetic Retinopathy, Eyes, Macular Degeneration, Macular Disorders, Ophthalmology, Surgical and Medical Diseases of the Retina

Research Interests

Novel laser therapies; Laser-tissue interactions; Molecular Imaging of the Eye


Yannis M. Paulus, M.D., has a particular interest in applying physics, bioengineering, and mathematical modeling to develop novel retinal imaging systems and therapeutic techniques and technologies, including laser therapies, surgical techniques, and molecular imaging. He completed his ophthalmology and chief residencies at Stanford University, a transitional year internship at Memorial Sloan-Kettering Cancer Center, medical school at Stanford University with a concentration in bioengineering, and an undergraduate degree at Harvard University in chemistry and physics. 

Dr. Paulus has co-developed a novel, inexpensive system for providing tele-ultrasound, co-founded an ophthalmic imaging company, and investigates pattern scanning laser photocoagulation, laser-tissue interactions, and restorative retinal laser therapy. He has received several entrepreneurship awards and published more than 40 peer-reviewed publications. Dr. Paulus is a leader of his professional community, including being President of the Hellenic American Professional Society of California and serving as a consultant for several medical device companies.


  • English
  • Greek


American Academy of Ophthalmology ; American Medical Association ; International Society for Eye Research ;  Association for Research in Vision and Ophthalmology (ARVO)

Additional Resources +
  • Education +


    • Stanford University School of Medicine (Stanford CA ) (2009)


    • Stanford University School of Medicine / Ophthalmology (Stanford CA ) (2013)
  • Research & Publications +

    Selected Publications

    1. Nugent AK, Paulus YM, Chan A, Kim JW, Schwartz EJ, Moshfeghi DM. Multiple Myeloma Recurrence with Optic Nerve Infiltration Diagnosed by Vitrectomy, Immunohistochemistry, and in-situ Hybridization. European Journal of Ophthalmology 24(3):446-8 (2014).

    2. Paulus YM, Kaur K, Egbert PR, Blumenkranz MS, Moshfeghi DM. Human Histopathology of PASCAL Laser Burns. Eye 27(8): 995-6 (2013).

    3. Paulus YM, Moshfeghi DM. Persistent Plus Disease after Laser in Retinopathy of Prematurity with Tetralogy of Fallot. European Journal of Ophthalmology 23(5): 764-6 (2013).

    4. Paulus YM, Cockerham GC. Abiotrophia defectiva Causing Infectious Crystalline Keratopathy and Corneal Ulcer after Penetrating Keratoplasty: A Case Report. Journal of Ophthalmic Inflammation and Infection 3(20): 1-3 (2013).

    5. Sher A, Jones BW, Huie P, Paulus YM, Lavinsky D, Leung LS, Nomoto H, Beier C, Marc RE, Palanker D. Restoration of Retinal Structure and Function after Selective Photocoagulation. The Journal of Neuroscience 33(16): 6800-8 (2013).

    6. Nomoto H, Lavinsky D, Paulus YM, Leung L-S, Dalal R, Blumenkranz MS, Palanker D. Effect of Intravitreal Triamcinolone Acetonide on Healing of Retinal Photocoagulation Lesions. Retina 33 (1): 63-70 (2013).

    7. Liu B, Hunter D, Rooker S, Chan A, Paulus YM, Leucht P, Nusse Y, Nomoto H, Helms J. Wnt signaling promotes Muller cell proliferation and survival after injury. The Investigative Ophthalmology & Visual Science (IOVS) 54(1): 444-53 (2013).

    8. Paulus YM, Cockerham KP, Cockerham GC, Gratzinger D. IgG4-positive Sclerosing Orbital Inflammation Involving the Conjunctiva: A Case Report. Ocular Immunology and Inflammation 20(5): 375-377 (2012).

    9. Paulus YM, Ta CN. Ocular Antibiotics. In Copeland and Afshari Principles and Practice of Cornea. New Delhi, India: Jaypee Brothers Medical Publisher, 2012.

    10. Paulus YM, Thompson NP. Inexpensive, Realtime Tele-ultrasound Using a commercial, web-based Video Streaming System. Journal of Telemedicine and Telecare 18(4): 185-8 (2012).

    11. Brodie S, Paulus YM, Patel M, Gobin PY, Dunkel IJ, Marr B, Abramson DH. ERG monitoring of retinal function during systemic chemotherapy for retinoblastoma. British Journal of Ophthalmology 96(6): 877-80 (2012).

    12. Sramek C, Leung L-S, Paulus YM, Palanker DV. Therapeutic window of retinal photocoagulation with green (532 nm) and yellow (577 nm) lasers. Ophthalmic Surgery Lasers, and Imaging 43(4): 341-7 (2012).

    13. Wang J, Sramek C, Paulus YM, Lavinsky D, Schuele G, Anderson D, Dewey D, Palanker D. Retinal Safety of Near-Infrared Lasers in Cataract Surgery. Journal of Biomedical Optics 17 (9): 95001-1 (2012).

    14. Leng T, Jaben KA, Zheng L, Yang J, Paulus YM, Moshfeghi AA, Maltenfort MG, Campbell PG, Ratliff JK, Moshfeghi DM. The influence of medical school and residency training program upon choice of an academic career and academic productivity among otolaryngology faculty in the United States: Our experience of 1433 academic otolaryngologists. Clin Otolaryngol 37(1): 58-62 (2012).

    15. Paulus YM. Medical and surgical retina editor, EyeHandbook application. Wrote articles on BRAO, CRVO, BRVO, retinoschisis, hypertensive retinopathy, optic pit, ocular ischemic syndrome, central serous chorioretinopathy, Purtscher's retinopathy, macular hole, rhegmatogenous retinal detachment, epiretinal membrane, endophthalmitis, retained lens material, dislocated IOL, and retinal break (2012 - 2013).

    16. Paulus YM, Sramek C, Blumenkranz MS, Palanker D. New Horizons in Retinal Laser Treatment: Sublethal Retinal Laser Therapy. Retinal Physician 8(2): 23 – 27 (2011).

    17. Paulus YM, Jain A, Nomoto H, Sramek C, Gariano RF, Andersen D, Schuele G, Leung L, Leng T, Palanker D. Selective Retinal Therapy with Microsecond Exposures using a Continuous Line Scanning Laser. Retina. 31(2): 380-8 (2011).

    18. Patel M, Paulus YM, Gobin YP, Djaballah H, Marr B, Dunkel IJ, Brodie S, Antczak C, Folberg R, Abramson DH. Intraarterial and Oral Digoxin Therapy for Retinoblastoma. Ophthalmic Genetics 32(3): 147-50 (2011).

    19. Sramek C, Leung L-S, Leng T, Brown J, Paulus YM, Schuele G, Palanker D. Improving the therapeutic window of retinal photocoagulation by spatial and temporal modulation of the laser beam. Journal of Biomedical Optics 16(2): 028004 (2011).

    20. Paulus YM. Pellucid Marginal Corneal Degeneration. Eyewiki Article (2011).

    21. Paulus YM, Wong AE, Chen B, Jacobson MT. Preputial Epidermoid Cyst: An Atypical Case of Acquired Pseudoclitoromegaly. Journal of Lower Genital Tract Disease. 14(4), 382-386 (2010).

    22. Paulus YM, Palanker D, Blumenkranz MS. Short-Pulse Laser Treatment: Redefining Retinal Therapy. Retinal Physician. 7(1): 54, 56-59 (2010).

    23. Paulus YM, Jain A, Gariano RF, Nomoto H, Schuele G, Sramek C, Charalel R, Palanker D. Selective Retinal Therapy with a Continuous Line Scanning Laser. In Ophthalmic Technologies XX, Ed Fabrice Manns, Per G. Söderberg, Arthur Ho, Proceedings of SPIE Vol. 7550 (SPIE, Bellingham, WA), 7550-0W-1 – 11 (2010).

    24. de la Zerda A, Paulus YM, Teed R, Bodapati S, Dollberg Y, Khuri-Yakub, BT, Blumenkranz, MS, Moshfeghi DM, Gambhir SS. Photoacoustic Ocular Imaging. Optics Letters. 35(3): 270 – 272 (2010).

    25. Sramek C, Brown J, Paulus YM, Nomoto H, Palanker D. Improved Safety of Retinal Photocoagulation with a Shaped Beam and Modulated Pulse. In Ophthalmic Technologies XX, Ed Fabrice Manns, Per G. Söderberg, Arthur Ho, Proceedings of SPIE Vol. 7550 (SPIE, Bellingham, WA), 7550-0V-1 – 10 (2010).

    26. Paulus YM, Jain A, Moshfeghi DM. Resolution of Persistent Exudative Retinal Detachment in a case of Sturge-Weber Due with Anti-VEGF Administration. Ocular Immunology and Inflammation. 17(4): 292-294 (2009).

    27. Sramek C, Paulus YM, Nomoto H, Huie P, Brown J, Palanker D. Dynamics of retinal photocoagulation and rupture. Journal of Biomedical Optics. 14(3): 034007 (2009).

    28. Paulus YM, T. Sanger. Cerebral Aspergillosis in a Pediatric Case of Systemic Lupus Erythematosus. H&P: The Stanford Medical Student Journal. 13(3): 4-7 (2009).

    29. Paulus YM, Gariano RF. Diabetic Retinopathy: A Growing Concern in an Aging Population. Geriatrics. 64(2): 16-20 (2009).

    30. Sramek C, Paulus YM, Nomoto H, Huie P, Palanker D. Finite Element Model of Thermal Processes in Retinal Photocoagulation. In Optical Interactions with Tissue and Cells XX, Ed Steven L. Jacques, E. Duco Jansen, William P. Roach, Proceedings of SPIE Vol. 7175 (SPIE, Bellingham, WA) 7175-1F (2009).

    31. Sramek C, Paulus YM, Nomoto H, Huie P, Palanker D. Computational Model of Retinal Photocoagulation and Rupture. In Ophthalmic Technologies XIX, Ed Fabrice Manns, Per G. Söderberg, Arthur Ho, Proceedings of SPIE Vol. 7163 (SPIE, Bellingham, WA), 7163-0T (2009).

    32. Paulus YM, Jain A, Gariano RF, Stanzel BV, Marmor M, Blumenkranz MS, Palanker D. Healing of Retinal Photocoagulation Lesions. Investigative Ophthalmology & Visual Science (IOVS). 49(12): 5540-5545 (2008).

    33. Jain A, Blumenkranz MS, Paulus YM, Wiltberger MW, Andersen DE, Huie P, Palanker D. Effect of Pulse Duration on Size and Character of the Lesion in Retinal Photocoagulation. Archives of Ophthalmology. 126 (1): 78-85 (2008).

    34. Jain A, Paulus YM, Cockerham GC, Kenyon KR. Keratoconus and Other Non- inflammatory Thinning Conditions. Duane's Foundations of Clinical Ophthalmology Vol 4, Chapter 16C. Ed. William Tasman, MD and Edward A. Jaeger, MD. Philadelphia: Lippincott Williams and Wilkens, 2008. Oct 1, 2008

    35. Palanker D, Paulus YM, Jain A, Huie P, Andersen D, Stanzel BV, Marmor MF, Blumenkranz MS. Minimally-traumatic Retinal Photocoagulation. In Ophthalmic Technologies XVIII, Ed Fabrice Manns, Per G. Söderberg, Arthur Ho, Proceedings of SPIE Vol. 6844 (SPIE, Bellingham, WA), 6844-A31 (2008).

    36. Paulus YM, Schroeder S. Working up Pediatric Hypoglycemia: A Case of Ketotic Hypoglycemia. H&P: The Stanford Medical Student Journal. 12 (1): 8-11 (2007).

    37. Palanker D, Jain A, Paulus YM, Andersen D, Blumenkranz M. Patterned Retinal Coagulation with a Scanning Laser. In Ophthalmic Technologies XVII, Ed Fabrice Manns, Per G. Söderberg, Arthur Ho, Proceedings of SPIE Vol. 6426 (SPIE, Bellingham, WA), 6426-1E (2007).

    38. Poulaki V, Iliaki E, Mitsiades NS, Mitsiades CS, Paulus YM, Bula D, Gragoudas ES, Miller JW. Inhibition of Hsp90 attenuates inflammation in endotoxin-induced uveitis. The FASEB (Federation of American Societies for Experimental Biology) Journal. 21 (9): 2113-23 (2007).

  • Academic Affiliations & Courses +
  • Activities & Honors +


    2014                 Selected to Editorial Board of the Journal of Ophthalmology and Clinical Research

    2014                 Selected as Associate Editor for retina section BMC Ophthalmology

    2013 - 2014       Awarded Wilmer Research Grant

    2013 - 2014       Selected as Heed Ophthalmic Foundation Fellow

    2013                 Selected as Editorial Board Member to Case Reports in Clinical Medicine

    2013                 Selected as Editorial Board Member to Clinical & Experimental Ophthalmology Journal

    2013                 Winner of the ASCRS Foundation Resident Excellence Award

    2013                 Selected as Starr E. Shulman MPA Fellow by the California Academy of Eye Physicians & Surgeons

    2013                 One of 4 residents selected for presentation at AUPO/RPB Research Forum

    2013                 Received a Certificate of Honor from the Hellenic American Professional Society

    2012                 Selected for the 7th Annual Heed Ophthalmic Foundation Residents Retreat

    2012                 Selected as Delegate to the California Medical Association House of Delegates

    2012                 Article Paulus et al “Healing…” is #1 IOVS Most-Read Articles during April 2012

    2012                 International Society for Eye Research (ISER) Travel Fellowship Recipient

    2011                 Selected as Alternate Delegate to California Medical Association House of Delegates

    2011                 Selected as clinical advisor to Stanford University Biodesign Graduate Course

    2011                 Received a citation for clinical excellence from the Director of the Veterans Administration Palo Alto Health Care System

    2010                 Selected to the Board of Councilors of the California Academy of Eye Physicians and Surgeons

    2010                 Selected as Greek America’s Forty Under Forty recognizing 40 leaders in the USA

    2009                 Stanford Bio-X Travel Grant Recipient

    2009                 Stanford University Scholarly Concentration Travel Grant Recipient

    2009                 Stanford Medical Student Association Travel Grant Recipient

    2009                 Finalist in the Stanford E-Challenge Competition for Entrepreneurs

    2009                 Placed 3rd of 60 groups in the HYSTA 5th Annual Entrepreneur Competition

    2009                 National Eye Institute Travel Grant Recipient for ARVO conference

    2008                 Dr. Frederick E.G. Valergakis Research Grant Recipient

    2008                 Vamvas Scholarship Recipient of the Hellenic American Medical & Dental Society of Southern California

    2008                 AHEPA Education Foundation P.A. Margaronis Scholarship Recipient

    2007, 2008        Dr. Anthony P. Bagatelos Medical Scholarship Recipient

    2007                 Dr. Leon Contos Graduate Fellowship Recipient

    2007                 Leonidas Lantzounis Research Grant Recipient

    2007                 Hellenic American Professional Society Academic Scholarship Recipient

    2006                 Stanford University Medical Scholars Research Fellowship Recipient

    2005                 Harvard University Senior Award for Excellence in Promoting Intercultural and Race Relations Recipient

  • Videos & Media +

    Lectures and Presentations

    5/7/13   ARVO (Association for Research in Vision and Ophthalmology)                                Seattle, WA

                Fifteen minute oral presentation titled "Serum Autoantibody Evaluation after Retinal Laser Injury in Mice"


    2/1/13   Association of University Professors of Ophthalmology(AUPO) 47th Annual Meeting        San Diego, CA

                Eight minute oral presentation “Oral Niacin as a Treatment for Retinal Vein Occlusions”


    7/25/12  XX Biennial Meeting of the International Society for Eye Research          Berlin, Germany

                Twenty minute oral presentation titled “Photoacoustic Imaging for Functional Evaluation of Ophthalmic Circulation”


    5/5/11   ARVO (Association for Research in Vision and Ophthalmology)                      Ft. Lauderdale, FL

                Fifteen minute oral presentation titled “Ophthalmic Photoacoustic Imaging for Blood Distribution Evaluation”


    5/1/10   ARVO – ISIE (International Society for Imaging of the Eye) 2010        Ft. Lauderdale, FL

    Fifteen minute oral presentation titled “Photoacoustic Imaging of the Eye”


    1/24/10SPIE Photonics West BiOS: Biomedical Optics                                    San Francisco, CA

                Fifteen minute oral presentation titled “Selective retinal therapy with a continuous line scanning laser”


    4/19/09 Unite for Sight 6th Annual Global Health & Innovation Summit                           New Haven, CT

    Hour panel talk titled “Healing of Retinal Photocoagulation Lesions and its Pharmaceutical Modulation”


    6/18/08  California Health Information Association State Convention                                   San Jose, CA

                General session hour presentation titled “Net-Gen Perspectives on Technology and Its Implications in Medical Practice”


    4/13/08 Unite for Sight 5th Annual International Health Conference                     New Haven, CT

    Hour panel talk titled “The Healing of Retinal Photocoagulation Lesions”


    4/15/07 Unite for Sight 4th Annual International Health Conference                        Stanford, CA

    Hour panel talk titled “Patterned Scanning Laser Photocoagulation: A New Approach to Retinal Treatment”


    9/19/06 Stanford Photonic Research Center Annual Symposium                                          Stanford, CA

    Fifteen minute presentation titled “Patterned Scanning Laser Photocoagulation”

  • Events +
  • Contact & Locations +


    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Phone: 410-955-5080
    Location Map
    Johns Hopkins Outpatient Center
    601 N. Caroline Street
    Baltimore, MD 21287
    Phone: 410-955-5080
    Location Map


    • Ophthalmology - Retina

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