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Yannis Mantas Paulus, M.D.

Assistant of Ophthalmology

Male  | Languages: English, Greek

Main Location

The Johns Hopkins Hospital


  • Assistant of Ophthalmology

Centers & Institutes



The Johns Hopkins Hospital

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-955-5080

Johns Hopkins Outpatient Center

601 N. Caroline Street
Baltimore, MD 21287 map
Phone: 410-955-5080


Diabetic Retinopathy, Eyes, Macular Degeneration, Macular Disorders, Ophthalmology, Surgical and Medical Diseases of the Retina

Research Interests

Molecular Imaging of the Eye; Laser-tissue interactions; Novel laser therapies


Yannis M. Paulus, M.D., has a particular interest in applying physics, bioengineering, and mathematical modeling to develop novel retinal imaging systems and therapeutic techniques and technologies, including laser therapies, surgical techniques, and molecular imaging. He completed his ophthalmology and chief residencies at Stanford University, a transitional year internship at Memorial Sloan-Kettering Cancer Center, medical school at Stanford University with a concentration in bioengineering, and an undergraduate degree at Harvard University in chemistry and physics. 

Dr. Paulus has co-developed a novel, inexpensive system for providing tele-ultrasound, co-founded an ophthalmic imaging company, and investigates pattern scanning laser photocoagulation, laser-tissue interactions, and restorative retinal laser therapy. He has received several entrepreneurship awards and published more than 40 peer-reviewed publications. Dr. Paulus is a leader of his professional community, including being President of the Hellenic American Professional Society of California and serving as a consultant for several medical device companies. more

    Additional Information

  • Education +


    • Stanford University School of Medicine / MD (2009)


    • Stanford University School of Medicine / Ophthalmology (2013)


    • American Board of Ophthalmology
  • Research & Publications +

    Selected Publications

    1. Nugent AK, Paulus YM, Chan A, Kim JW, Schwartz EJ, Moshfeghi DM. Multiple Myeloma Recurrence with Optic Nerve Infiltration Diagnosed by Vitrectomy, Immunohistochemistry, and in-situ Hybridization. European Journal of Ophthalmology 24(3):446-8 (2014).

    2. Paulus YM, Kaur K, Egbert PR, Blumenkranz MS, Moshfeghi DM. Human Histopathology of PASCAL Laser Burns. Eye 27(8): 995-6 (2013).

    3. Paulus YM, Moshfeghi DM. Persistent Plus Disease after Laser in Retinopathy of Prematurity with Tetralogy of Fallot. European Journal of Ophthalmology 23(5): 764-6 (2013).

    4. Paulus YM, Cockerham GC. Abiotrophia defectiva Causing Infectious Crystalline Keratopathy and Corneal Ulcer after Penetrating Keratoplasty: A Case Report. Journal of Ophthalmic Inflammation and Infection 3(20): 1-3 (2013).

    5. Sher A, Jones BW, Huie P, Paulus YM, Lavinsky D, Leung LS, Nomoto H, Beier C, Marc RE, Palanker D. Restoration of Retinal Structure and Function after Selective Photocoagulation. The Journal of Neuroscience 33(16): 6800-8 (2013).

    6. Nomoto H, Lavinsky D, Paulus YM, Leung L-S, Dalal R, Blumenkranz MS, Palanker D. Effect of Intravitreal Triamcinolone Acetonide on Healing of Retinal Photocoagulation Lesions. Retina 33 (1): 63-70 (2013).

    7. Liu B, Hunter D, Rooker S, Chan A, Paulus YM, Leucht P, Nusse Y, Nomoto H, Helms J. Wnt signaling promotes Muller cell proliferation and survival after injury. The Investigative Ophthalmology & Visual Science (IOVS) 54(1): 444-53 (2013).

    8. Paulus YM, Cockerham KP, Cockerham GC, Gratzinger D. IgG4-positive Sclerosing Orbital Inflammation Involving the Conjunctiva: A Case Report. Ocular Immunology and Inflammation 20(5): 375-377 (2012).

    9. Paulus YM, Ta CN. Ocular Antibiotics. In Copeland and Afshari Principles and Practice of Cornea. New Delhi, India: Jaypee Brothers Medical Publisher, 2012.

    10. Paulus YM, Thompson NP. Inexpensive, Realtime Tele-ultrasound Using a commercial, web-based Video Streaming System. Journal of Telemedicine and Telecare 18(4): 185-8 (2012).

    11. Brodie S, Paulus YM, Patel M, Gobin PY, Dunkel IJ, Marr B, Abramson DH. ERG monitoring of retinal function during systemic chemotherapy for retinoblastoma. British Journal of Ophthalmology 96(6): 877-80 (2012).

    12. Sramek C, Leung L-S, Paulus YM, Palanker DV. Therapeutic window of retinal photocoagulation with green (532 nm) and yellow (577 nm) lasers. Ophthalmic Surgery Lasers, and Imaging 43(4): 341-7 (2012).

    13. Wang J, Sramek C, Paulus YM, Lavinsky D, Schuele G, Anderson D, Dewey D, Palanker D. Retinal Safety of Near-Infrared Lasers in Cataract Surgery. Journal of Biomedical Optics 17 (9): 95001-1 (2012).

    14. Leng T, Jaben KA, Zheng L, Yang J, Paulus YM, Moshfeghi AA, Maltenfort MG, Campbell PG, Ratliff JK, Moshfeghi DM. The influence of medical school and residency training program upon choice of an academic career and academic productivity among otolaryngology faculty in the United States: Our experience of 1433 academic otolaryngologists. Clin Otolaryngol 37(1): 58-62 (2012).

    15. Paulus YM. Medical and surgical retina editor, EyeHandbook application. Wrote articles on BRAO, CRVO, BRVO, retinoschisis, hypertensive retinopathy, optic pit, ocular ischemic syndrome, central serous chorioretinopathy, Purtscher's retinopathy, macular hole, rhegmatogenous retinal detachment, epiretinal membrane, endophthalmitis, retained lens material, dislocated IOL, and retinal break (2012 - 2013).

    16. Paulus YM, Sramek C, Blumenkranz MS, Palanker D. New Horizons in Retinal Laser Treatment: Sublethal Retinal Laser Therapy. Retinal Physician 8(2): 23 – 27 (2011).

    17. Paulus YM, Jain A, Nomoto H, Sramek C, Gariano RF, Andersen D, Schuele G, Leung L, Leng T, Palanker D. Selective Retinal Therapy with Microsecond Exposures using a Continuous Line Scanning Laser. Retina. 31(2): 380-8 (2011).

    18. Patel M, Paulus YM, Gobin YP, Djaballah H, Marr B, Dunkel IJ, Brodie S, Antczak C, Folberg R, Abramson DH. Intraarterial and Oral Digoxin Therapy for Retinoblastoma. Ophthalmic Genetics 32(3): 147-50 (2011).

    19. Sramek C, Leung L-S, Leng T, Brown J, Paulus YM, Schuele G, Palanker D. Improving the therapeutic window of retinal photocoagulation by spatial and temporal modulation of the laser beam. Journal of Biomedical Optics 16(2): 028004 (2011).

    20. Paulus YM. Pellucid Marginal Corneal Degeneration. Eyewiki Article (2011).

    21. Paulus YM, Wong AE, Chen B, Jacobson MT. Preputial Epidermoid Cyst: An Atypical Case of Acquired Pseudoclitoromegaly. Journal of Lower Genital Tract Disease. 14(4), 382-386 (2010).

    22. Paulus YM, Palanker D, Blumenkranz MS. Short-Pulse Laser Treatment: Redefining Retinal Therapy. Retinal Physician. 7(1): 54, 56-59 (2010).

    23. Paulus YM, Jain A, Gariano RF, Nomoto H, Schuele G, Sramek C, Charalel R, Palanker D. Selective Retinal Therapy with a Continuous Line Scanning Laser. In Ophthalmic Technologies XX, Ed Fabrice Manns, Per G. Söderberg, Arthur Ho, Proceedings of SPIE Vol. 7550 (SPIE, Bellingham, WA), 7550-0W-1 – 11 (2010).

    24. de la Zerda A, Paulus YM, Teed R, Bodapati S, Dollberg Y, Khuri-Yakub, BT, Blumenkranz, MS, Moshfeghi DM, Gambhir SS. Photoacoustic Ocular Imaging. Optics Letters. 35(3): 270 – 272 (2010).

    25. Sramek C, Brown J, Paulus YM, Nomoto H, Palanker D. Improved Safety of Retinal Photocoagulation with a Shaped Beam and Modulated Pulse. In Ophthalmic Technologies XX, Ed Fabrice Manns, Per G. Söderberg, Arthur Ho, Proceedings of SPIE Vol. 7550 (SPIE, Bellingham, WA), 7550-0V-1 – 10 (2010).

    26. Paulus YM, Jain A, Moshfeghi DM. Resolution of Persistent Exudative Retinal Detachment in a case of Sturge-Weber Due with Anti-VEGF Administration. Ocular Immunology and Inflammation. 17(4): 292-294 (2009).

    27. Sramek C, Paulus YM, Nomoto H, Huie P, Brown J, Palanker D. Dynamics of retinal photocoagulation and rupture. Journal of Biomedical Optics. 14(3): 034007 (2009).

    28. Paulus YM, T. Sanger. Cerebral Aspergillosis in a Pediatric Case of Systemic Lupus Erythematosus. H&P: The Stanford Medical Student Journal. 13(3): 4-7 (2009).

    29. Paulus YM, Gariano RF. Diabetic Retinopathy: A Growing Concern in an Aging Population. Geriatrics. 64(2): 16-20 (2009).

    30. Sramek C, Paulus YM, Nomoto H, Huie P, Palanker D. Finite Element Model of Thermal Processes in Retinal Photocoagulation. In Optical Interactions with Tissue and Cells XX, Ed Steven L. Jacques, E. Duco Jansen, William P. Roach, Proceedings of SPIE Vol. 7175 (SPIE, Bellingham, WA) 7175-1F (2009).

    31. Sramek C, Paulus YM, Nomoto H, Huie P, Palanker D. Computational Model of Retinal Photocoagulation and Rupture. In Ophthalmic Technologies XIX, Ed Fabrice Manns, Per G. Söderberg, Arthur Ho, Proceedings of SPIE Vol. 7163 (SPIE, Bellingham, WA), 7163-0T (2009).

    32. Paulus YM, Jain A, Gariano RF, Stanzel BV, Marmor M, Blumenkranz MS, Palanker D. Healing of Retinal Photocoagulation Lesions. Investigative Ophthalmology & Visual Science (IOVS). 49(12): 5540-5545 (2008).

    33. Jain A, Blumenkranz MS, Paulus YM, Wiltberger MW, Andersen DE, Huie P, Palanker D. Effect of Pulse Duration on Size and Character of the Lesion in Retinal Photocoagulation. Archives of Ophthalmology. 126 (1): 78-85 (2008).

    34. Jain A, Paulus YM, Cockerham GC, Kenyon KR. Keratoconus and Other Non- inflammatory Thinning Conditions. Duane's Foundations of Clinical Ophthalmology Vol 4, Chapter 16C. Ed. William Tasman, MD and Edward A. Jaeger, MD. Philadelphia: Lippincott Williams and Wilkens, 2008. Oct 1, 2008

    35. Palanker D, Paulus YM, Jain A, Huie P, Andersen D, Stanzel BV, Marmor MF, Blumenkranz MS. Minimally-traumatic Retinal Photocoagulation. In Ophthalmic Technologies XVIII, Ed Fabrice Manns, Per G. Söderberg, Arthur Ho, Proceedings of SPIE Vol. 6844 (SPIE, Bellingham, WA), 6844-A31 (2008).

    36. Paulus YM, Schroeder S. Working up Pediatric Hypoglycemia: A Case of Ketotic Hypoglycemia. H&P: The Stanford Medical Student Journal. 12 (1): 8-11 (2007).

    37. Palanker D, Jain A, Paulus YM, Andersen D, Blumenkranz M. Patterned Retinal Coagulation with a Scanning Laser. In Ophthalmic Technologies XVII, Ed Fabrice Manns, Per G. Söderberg, Arthur Ho, Proceedings of SPIE Vol. 6426 (SPIE, Bellingham, WA), 6426-1E (2007).

    38. Poulaki V, Iliaki E, Mitsiades NS, Mitsiades CS, Paulus YM, Bula D, Gragoudas ES, Miller JW. Inhibition of Hsp90 attenuates inflammation in endotoxin-induced uveitis. The FASEB (Federation of American Societies for Experimental Biology) Journal. 21 (9): 2113-23 (2007).

  • Academic Affiliations & Courses +
  • Activities & Honors +


    • Senior Award for Excellence in Promoting Intercultural and Race Relations Recipient, Harvard University , 2005
    • Research Fellowship Recipient, Stanford University Medical Scholars, 2006
    • Academic Scholarship Recipient, Hellenic American Professional Society , 2007
    • Dr. Anthony P. Bagatelos Medical Scholarship Recipient, 2007 - 2008
    • Dr. Leon Contos Graduate Fellowship Recipient, 2007
    • Leonidas Lantzounis Research Grant Recipient, 2007
    • Dr. Frederick E.G. Valergakis Research Grant Recipient, 2008
    • P.A. Margaronis Scholarship Recipient, AHEPA Education Foundation , 2008
    • Vamvas Scholarship Recipient, Hellenic American Medical & Dental Society of Southern California, 2008
    • Finalist, Stanford E-Challenge Competition for Entrepreneurs, 2009
    • Placed 3rd of 60 groups, HYSTA 5th Annual Entrepreneur Competition, 2009
    • Travel Grant Recipient, Stanford Bio-X , 2009
    • Travel Grant Recipient, Stanford University Scholarly Concentration , 2009
    • Travel Grant Recipient, Stanford Medical Student Association , 2009
    • Travel Grant Recipient for ARVO conference, National Eye Institute , 2009
    • Selected as Greek America’s Forty Under Forty recognizing 40 leaders in the USA, 2010
    • Selected to the Board of Councilors, California Academy of Eye Physicians and Surgeons, 2010
    • Received a citation for clinical excellence from the Directo, Veterans Administration Palo Alto Health Care System, 2011
    • Selected as Alternate Delegate to California Medical Association House of Delegates, California Medical Association, 2011
    • Selected as clinical advisor, Stanford University, 2011
    • Article Paulus et al “Healing…” is #1 IOVS Most-Read Articles during April 2012, IOVS, 2012
    • Selected as Delegate to the California Medical Association House of Delegates, California Medical Association House of Delegates, 2012
    • Selected for the 7th Annual Residents Retreat, Heed Ophthalmic Foundation , 2012
    • Travel Fellowship Recipient, International Society for Eye Research (ISER), 2012
    • Fellow, Heed Ophthalmic Foundation , 2013 - 2014
    • Foundation Resident Excellence Award, ASCRS , 2013
    • One of 4 residents selected for presentation at AUPO/RPB Research Forum, 2013
    • Received a Certificate of Honor, Hellenic American Professional Society, 2013
    • Selected as Editorial Board Member to Case Reports in Clinical Medicine, 2013
    • Selected as Editorial Board Member to Clinical & Experimental Ophthalmology Journal, 2013
    • Starr E. Shulman MPA Fellow, California Academy of Eye Physicians & Surgeons, 2013
    • Wilmer Research Grant, 2013 - 2014
    • Selected as Associate Editor for retina section BMC Ophthalmology, 2014
    • Selected to Editorial Board of the Journal of Ophthalmology and Clinical Research, 2014


    • American Academy of Ophthalmology
    • American Medical Association
    • Association for Research in Vision and Ophthalmology (ARVO)
    • International Society for Eye Research
  • Videos & Media +

    Lectures and Presentations

    Serum Autoantibody Evaluation after Retinal Laser Injury in Mice
    ARVO (Association for Research in Vision and Ophthalmology) , Seattle, WA (01/07/2013)

    Oral Niacin as a Treatment for Retinal Vein Occlusions
    Association of University Professors of Ophthalmology(AUPO) 47th Annual Meeting         , San Diego, CA (01/01/2013)

    Photoacoustic Imaging for Functional Evaluation of Ophthalmic Circulation
     XX Biennial Meeting of the International Society for Eye Research          ,  Berlin, Germany (01/25/2012)

    Ophthalmic Photoacoustic Imaging for Blood Distribution Evaluation
    ARVO (Association for Research in Vision and Ophthalmology)                       , Ft. Lauderdale, FL (01/05/2011)

    Photoacoustic Imaging of the Eye
    ARVO – ISIE (International Society for Imaging of the Eye) 2010         , Ft. Lauderdale, FL (01/01/2010)

    Selective retinal therapy with a continuous line scanning laser
    SPIE Photonics West BiOS: Biomedical Optics                                    ,  San Francisco, CA (01/24/2010)

    Healing of Retinal Photocoagulation Lesions and its Pharmaceutical Modulation
    Unite for Sight 6th Annual Global Health & Innovation Summit                            , New Haven, CT (01/19/2009)

    Net-Gen Perspectives on Technology and Its Implications in Medical Practice
    California Health Information Association State Convention                                   ,  San Jose, CA (01/18/2008)

    The Healing of Retinal Photocoagulation Lesions
    Unite for Sight 5th Annual International Health Conference                      , New Haven, CT (01/13/2008)

    Patterned Scanning Laser Photocoagulation: A New Approach to Retinal Treatment
    Unite for Sight 4th Annual International Health Conference                         , Stanford, CA (01/15/2007)

    Patterned Scanning Laser Photocoagulation
    Stanford Photonic Research Center Annual Symposium                                           , Stanford, CA (01/19/2006)

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