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Shaoyong Yu, M.D.

Photo of Dr. Shaoyong Yu, M.D.

Assistant Professor

Assistant Professor of Medicine

Background

Dr. Shaoyong Yu is Assistant Professor of Medicine in the Gastroenterology and Hepatology division. He studies neurogastroenterology and motility.

Dr. Yu received medical and master’s degrees from Tongji Medical University, and a master of public health degree from the Johns Hopkins Bloomberg School of Public Health before joining the Johns Hopkins faculty.

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Titles

  • Assistant Professor
  • Assistant Professor of Medicine

Education

Degrees

  • M.D., Yichang Medical College (China) (1986)

Additional Training

Johns Hopkins University School of Medicine, Division of Gastroenterology and Hepatology, Baltimore, MD, Research Fellow; Johns Hopkins University School of Medicine, Division of Gastroenterology and Hepatology, Baltimore, MD, Research Fellow

Research & Publications

Research Summary

Dr. Yu's research has been focused on neuro-immune interactions in the GI tract. Specifically, he is interested in studying the cellular and molecular mechanisms underlying sensory nerve plasticity and esophageal sensory and motor dysfunction.

Lab

The research projects in my lab focus on immun-nerve interactions in the esophagus.

A post-doc position is opening to investigate the molecular and cellular mechanisms of visceral sensation and nociception for self-motivated individual who has been trained in electrophysiology (patch clamp and/or extra-cellular recording).

Technology Expertise Keywords

GI Physiology, Neurobiology, and Mucosal Immunology

Selected Publications

  1. Yu S., Undem BJ, Kollarik M. Vagal afferent nerves with nociceptive properties in guinea-pig oesophagus. J Physiol. 2005;563(Pt 3):831-42.
  2. Yu S, Kollarik M, Ouyang A, Myers AC, Undem BJ. Mast cell-mediated long-lasting increases in excitability of vagal C fibers in guinea pig esophagus. Am J Physiol Gastrointest Liver Physiol. 2007;293(4):G850-6.
  3. Yu S, Stahl E, Li Q, Ouyang A. Antigen inhalation induces mast cells and eosinophils infiltration in the guinea pig esophageal epithelium involving histamine-mediated pathway. Life Sci. 2008;82:324-330.
  4. Yu S, Ouyang A. TRPA1 in bradykinin-induced mechanical hypersensitivity of vagal C fibers in guinea pig esophagus. Am J Physiol Gastrointest Liver Physiol. 2009; 296(2):G255-65.
  5. Yu S, Gao GF, Peterson BZ, Ouyang A. TRPA1 in Mast Cell Activation-induced Long-lasting Mechanical Hypersensitivity of Vagal Afferent C fibers in Guinea Pig Esophagus. Am J Physiology Gastrointestinal & Liver. 2009;297(1):G34-42.
  6. Yu S. Ouyang A. Effect of Cationic Protein on Mechano-excitability of Vagal Afferent Nerve Subtypes in Guinea Pig Esophagus. Am J Physiology Gastrointestinal & Liver Physiol. 2011; 301:G1052-G1058.
  7. Zhang S, Grabauskas G, Wu X, Joo MK, Heldsinger A, Song I, Owyang C, Yu S. Role of Prostaglandin D2 in Mast Cell Activation-induced Sensitization of Esophageal Vagal Afferents. Am J Physiology Gastrointestinal & Liver Physiol 2013; 305: G908-16.
  8. Zhang S, Liu Z, Heldsinger A, Owyang C, Yu S. Intraluminal acid activates esophageal nodose C fibers after mast cell activation. Am J Physiol Gastrointest Liver Physiol. 2014,306(:G200-7.

  9. Hu Y, Liu Z, Yu X, Pasricha PJ, Undem BJ, Yu S. Increased Acid Responsiveness in Vagal Sensory Neurons in a Guinea Pig Model of Eosinophilic Esophagitis. Am J Physiol Gastrointest Liver Physiol 2014, 307: G149-57.
  10. Yu XY, Hu Y, Yu S. Effects of Acid on Vagal Nociceptive Afferent Subtypes in Guinea Pig Esophagus. Am J Physiol Gastrointest Liver Physiol 2014, 307: G471-8.
  11. Liu Z, Hu Y, Yu X, Xi J, Fan X, Tse CM, Myers AC, Pasricha PJ, Li X, Yu S. Allergen challenge Sensitizes TRPA1 in Vagal Sensory Neurons and Afferent C-fiber subtypes in Guinea Pig Esophagus. Am J Physiol Gastrointest Liver Physiol. 2015, 308: G482-8.
  12. Yu X, Hu Y, Ru F, Kollarik M, Undem BJ, Yu S. TRPM8 Function and Expression in Vagal Sensory Neurons and Afferent Nerves Innervating Guinea Pig Esophagus. Am J Physiol Gastrointest Liver Physiol. 2015, 308: G489-96.
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