Research Summary
Our research projects focus on sensory afferent neurobiology and nerve-immune interactions in the GI tract. Specifically, we are interested in studying the cellular and molecular mechanisms underlying vagal afferent nerve activation and mast cell activation-induced sensitization of vagal nociceptive afferents in the esophagus.
For research inquiries please contact Dr. Yu via email at [email protected].
Technology Expertise Keywords
Esophageal Physiology, Vagal Afferent Neurobiology, and Mast Cell Biology
Selected Publications
View all on PubMed
Hu Y, Liu Z, Yu X, Pasricha PJ, Undem BJ, Yu S. Increased acid responsiveness in vagal sensory neurons in a guinea pig model of eosinophilic esophagitis. Am J Physiol Gastrointest Liver Physiol. 2014 Jul 15;307(2):G149-57
Yu X, Hu Y, Yu S. Effects of acid on vagal nociceptive afferent subtypes in guinea pig esophagus. Am J Physiol Gastrointest Liver Physiol. 2014 Aug 15;307(4):G471-8
Yu X, Yu M, Liu Y, Yu S. TRP channel functions in the gastrointestinal tract. Semin Immunopathol. 2016 May;38(3):385-96
Yu X, Hu Y, Yu M, Undem BJ, Yu S. Deoxycholic acid activates and sensitizes vagal nociceptive afferent C-fibers in guinea pig esophagus. Am J Physiol Gastrointest Liver Physiol. 2021 Aug 1;321(2):G149-G156
Patil MJ, Huang Y, Yu M, Dong X, Undem BJ, Yu S. Ginger Constituent 6-Shogaol Attenuates Vincristine-Induced Activation of Mouse Gastroesophageal Vagal Afferent C-Fibers. Molecules. 2022 Nov 2;27(21):7465
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