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Christopher James VandenBussche, M.D., Ph.D.
Associate Director, Cytopathology Division
Assistant Professor of Pathology
Expertise: Bladder Cancer, Pathology
The Johns Hopkins Hospital
600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Johns Hopkins Outpatient Center
601 N. Caroline St.
Baltimore, MD 21287 map
Johns Hopkins Bayview Medical Center
4940 Eastern Avenue
Baltimore, MD 21224 map
Dr. Christopher VandenBussche is an assistant professor of pathology at the Johns Hopkins University School of Medicine. His areas of clinical expertise include bladder cancer and pathology. Dr. VandenBussche serves as the associate director of the Division of Cytopathology.
Dr. VandenBussche earned his M.D. and Ph.D. from Georgetown University School of Medicine. He completed his residency at Johns Hopkins and performed a fellowship in cytopathology at Johns Hopkins.
- Associate Director, Cytopathology Division
- Assistant Professor of Pathology
Centers & Institutes
- MD PhD, Georgetown University School of Medicine (2009)
- Johns Hopkins University School of Medicine / Anatomic and Clinical Pathology (2013)
- Johns Hopkins University School of Medicine / Cytopathology
- American Board of Pathology / Anatomic & Clinical Pathology (2013)
- American Board of Pathology / Cytopathology (2014)
Research & Publications
Dr. VandenBussche’s research focuses on urinary cytopathology. In addition to clinical research in the area of bladder cancer, he is working on several genetic, molecular and immunological ancillary assays to improve diagnostic ability.
He is also interested in the impact of policy changes and scientific advancements on both the practice of gynecologic cytopathology and the clinical and biological behavior of the human papillomavirus (HPV).
VandenBussche CJ, Rosenthal DL, Olson MT. Adequacy in voided urine cytology specimens: the role of volume and a repeat void upon predictive values for high grade urothelial carcinoma. Cancer Cytopathol. In press.
Nguyen DN, Kawamoto S, Cimino-Mathews A, Illei PB, VandenBussche CJ. Metastatic metaplastic breast carcinoma mimicking pulmonary squamous cell carcinoma on fine-needle aspiration. Diagn Cytopathol. In press. PMID: 26238413
VandenBussche CJ, Cimino-Mathews A, Park BH MD, Emens LA, Tsangaris TN, Argani P. Reflex ER/PR/Her2 analysis of breast cancers in needle core biopsy specimens dramatically increases health care costs. Am J Surg Path 2015; 39(7):939-47. PMID: 25871620
Michailidi C, Hayashi M, Datta S, Sen T, Zenner K, Oladeru O, Brait M, Izumchenko E, Baras A, VandenBussche C, Argos M, Bivalacqua TJ, Ahsan H, Hahn NM, Netto GJ, Sidransky D, Hoque MO. Involvement of epigenetics and EMT related miRNA in arsenic induced neoplastic transformation and their potential clinical use. Cancer Prev Res 2015;8(3):208-21. PMID: 25586904
Onur I, Rosenthal DL, VandenBussche CJ. Atypical urothelial tissue fragments in noninstrumented voided urine specimens are associated with low but significantly higher rates of urothelial neoplasia than benign-appearing urothelial tissue fragments. Cancer Cytopathol 2015;123(3):186-192. PMID: 25586692
Onur I, Rosenthal DL, VandenBussche CJ. Benign-appearing urothelial tissue fragments in noninstrumented voided urine specimens are associated with low rates of urothelial neoplasia. Cancer Cytopathol 2015;123(3):180-185. PMID: 25586552
VandenBussche CJ, Illei PB, Lin M, Ettinger DS, Maleki Z. Molecular alterations in non-small cell carcinomas of the young. Hum Pathol 2014;45(12):2379-87. PMID: 25288236
Gurda GT*, VandenBussche CJ*, Yonescu R, Gonzalez-Roibon N, Ellis CL, Batista DA, Netto GJ. Saccrococcygeal teratomas: clinico-pathological characteristics and isochromosome 12p status. Mod Pathol 2014; 27:562-8. PMID: 24051698. * authors contributed equally
VandenBussche CJ, Elwood H, Cimino-Mathews A, Illei PB, Warzecha HN. Clinicopathologic features of ductal carcinoma in situ in young women with an emphasis on molecular subtype. Hum Pathol 2013; 44(11):2487-93. PMID: 24029706.
VandenBussche CJ, Khouri N, Sbaity E, Tsangaris TN, Vang R, Tatsas A, Cimino-Mathews A, Argani P. Borderline atypical ductal hyperplasia/low grade ductal carcinoma in situ on breast needle core biopsy should be managed conservatively. Am J Surg Pathol. 2013; 37(6):913-23. PMID: 23598968.
VandenBussche CJ, Sathiyamoorthy S, Owens CL, Burroughs FH, Rosenthal DL, Guan H. The Johns Hopkins Hospital template for urologic cytology samples: Parts II and III-Improving the predictability of indeterminate results in urinary cytology samples: an outcomes and cytomorphologic study. Cancer Cytopathol 2012; 121(1):21-8. PMID: 23192913.