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Mary Glenn Fowler, M.D., M.P.H.

Photo of Dr. Mary Glenn Fowler, M.D., M.P.H.

Professor of Pathology

Research Interests: Prevention and treatment of pediatric and HIV infection

Background

Dr. Mary Fowler is a professor of pathology at the Johns Hopkins University School of Medicine. She also has an appointment in the Johns Hopkins Bloomberg School of Public Health in the Department of International Health.

As a pediatrician and clinical researcher Dr. Fowler has devoted her career to prevention of mother to child transmission (PMTCT) and treatment and care of pediatric HIV infection.  Her research focuses on medical microbiology and HIV.

Dr. Fowler earned her M.D. from the University of Oregon and her M.P.H from the Johns Hopkins Bloomberg School of Public Health.

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Titles

  • Professor of Pathology

Departments / Divisions

Centers & Institutes

Research & Publications

Research Summary

Since the early 1990's Dr. Fowler has worked on a number of the key phase I-III perinatal and pediatric HIV treatment clinical trials conducted both in the U.S and in international settings. These include some of the early treatment trials of pediatric antiretrovirals as well as international trials for prevention of mother to child transmission of HIV (PMTCT) including the HIVNET 06 and 012 trials the PEPI infant prophylaxis trial, the Kisumu Infant Breastfeeding trial, Kesha Bora Trial in Nairobi, the HIVIGLOB/ SWEN trial, the HPTN 027 ALVAC perinatal vaccine trial, and the HPTN 046 trial of extended infant nevirapine infant prophylaxis.

Most recently Dr. Fowler has served as Chair of the NIH supported PROMISE trial (1077BF/1077FF), a large multisite PMTCT trial within the IMPAACT network assessing what the optimal strategies are for both PMTCT, safety and improving maternal and infant health. In addition, Dr. Fowler oversee studies of HIV primary prevention using microbicides and oral antiretroviral agents in Kampala Uganda at as part of the MTN network. These primary prevention trials include both young and older women, ages 18-49 who are at high risk for HIV acquisition.

Selected Publications

Palaia JM, McConnell M, Achenbach JE, Gustafson CE, Stoermer KA, Nolan M, Guay LA, Leitner TK, Matovu F, Taylor AW, Fowler MG, Janoff EN. "Neutralization of HIV subtypes A and D by breast milk IgG from women with HIV infection in Uganda." J Infect. 2014 Mar;68(3):264-72. doi: 10.1016/j.jinf.2013.11.002. Epub 2013 Nov 13.

Fowler MG, Coovadia H, Herron CM, Maldonado Y, Chipato T, Moodley D, Musoke P, Aizire J, Manji K, Stranix-Chibanda L, Fawzi W, Chetty V, Msweli L, Kisenge R, Brown E, Mwatha A, Eshleman SH, Richardson P, Allen M, George K, Andrew P, Zwerski S, Mofenson LM, Jackson JB; HPTN 046 Protocol Team. "Efficacy and safety of an extended nevirapine regimen in infants of breastfeeding mothers with HIV-1 infection for prevention of HIV-1 transmission (HPTN 046): 18-month results of a randomized, double-blind, placebo-controlled trial." J Acquir Immune Defic Syndr. 2014 Mar 1;65(3):366-74. doi: 10.1097/QAI.0000000000000052.

Kaleebu P, Njai HF, Wang L, Jones N, Ssewanyana I, Richardson P, Kintu K, Emel L, Musoke P, Fowler MG, Ou SS, Jackson JB, Guay L, Andrew P, Baglyos L, Cao H; HPTN 027 protocol team. "Immunogenicity of ALVAC-HIV vCP1521 in infants of HIV-1-infected women in Uganda (HPTN 027): the first pediatric HIV vaccine trial in Africa." J Acquir Immune Defic Syndr. 2014 Mar 1;65(3):268-77. doi: 10.1097/01.qai.0000435600.65845.31.

Mirochnick M, Taha T, Kreitchmann R, Nielsen-Saines K, Kumwenda N, Joao E, Pinto J, Santos B, Parsons T, Kearney B, Emel L, Herron C, Richardson P, Hudelson SE, Eshleman SH, George K, Fowler MG, Sato P, Mofenson L; HPTN 057 Protocol Team. "Pharmacokinetics and safety of tenofovir in HIV-infected women during labor and their infants during the first week of life." J Acquir Immune Defic Syndr. 2014 Jan 1;65(1):33-41. doi: 10.1097/QAI.0b013e3182a921eb.

Owor M, Mwatha A, Donnell D, Musoke P, Mmiro F, Allen M, Jackson JB, Fowler MG, Guay LA. "Long-term follow-up of children in the HIVNET 012 perinatal HIV prevention trial: five-year growth and survival." J Acquir Immune Defic Syndr. 2013 Dec 15;64(5):464-71. doi: 10.1097/QAI.0000000000000015.

Videos & Media

Recent News Articles and Media Coverage

Extended Interview: Dr. Mary Glenn Fowler, PBS NewsHour, November 6, 2003

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