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Michael Anthony Jacobs, Ph.D.

Photo of Dr. Michael Anthony Jacobs, Ph.D.

Director, Imaging Radiological Assessment Team (IRAT), Sidney Kimmel Comprehensive Cancer Center

Associate Professor of Radiology and Radiological Science

Expertise: Breast Imaging , Magnetic Resonance Imaging, New Imaging Modalities, Radiology

Research Interests: Image analysis MRI/MRSI; Breast cancer imaging; New analysis tools for MRI and other imaging; Novel multiparametric MRI and PET/CT assessment; High Intensity Focused Ultrasound; Prostate Imaging more


Dr. Michael A. Jacobs is an Associate Professor in the Johns Hopkins Medicine Department of Radiology and Radiological Science. His research focuses on developing radiological methods for detecting, monitoring, and treating breast cancer, with a particular focus on transferring research from the lab to the clinic.  He is Board Certifed in Diagnostic Medical Physics by the American Board of Radiology.

Dr. Jacobs received his undergraduate degree in mathematics and engineering science from the University of Michigan-Flint. He earned his Ph.D. in biomedical physics from Oakland University. He completed his fellowship in radiology at the Johns Hopkins University School of Medicine. Dr. Jacobs joined the Johns Hopkins faculty in 2003.

He serves on the National Board of the American College of Radiology Imaging Network (ACRIN) Breast Imaging committee, as a member of the subcommittee of molecular and functional imaging of the ACRIN and as co-director of the Imaging Radiological Assessment Team (IRAT) of the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. He is also one of the principal investigators on the Quantitative Imaging Network (QIN) U01 at Johns Hopkins University for developing novel methods for determining treatment response in clinical trials.

His work has been recognized with numerous awards and honors, including the 2012 Distinguished Investigator Awards from the Academy of Radiology Research, three Certificate of Merit Awards at the Radiological Society of North America, a bronze medal from the American Roentgen Ray Society and a National Research Service Awards Cancer Research Training Grant. He also was awarded three patents for his work related to radiological imaging. more


  • Director, Imaging Radiological Assessment Team (IRAT), Sidney Kimmel Comprehensive Cancer Center
  • Associate Professor of Radiology and Radiological Science

Departments / Divisions



  • B.S., University of Michigan (Michigan) (1993)
  • Ph.D., Oakland University (Michigan) (1999)

Additional Training

  • Diagnostic Medical Physics, American Board of Radiology (2014)
Departments of Neurology and Radiology, Henry Ford Hospital, Detroit, MI, 2000, Stroke Research Coordinator; Depts. of Neurology and Radiology. Henry Ford Hospital, Detroit, MI, 1999, Senior Research Assistant; Mathematics Dept. Oakland University, Detroit, MI, 1995, Graduate Research Assistant; United States Air Force: Non Commissioned Officer (NCO), Wilford Hall Medical Center (Level 1 Trauma Center), San Antonio, TX, 1992, Asst. NCOIC Supervisor of Emergency Room Medical Technicians; The Johns Hopkins University School of Medicine, Baltimore, MD, 2002, Radiological Fellow

Research & Publications

Research Summary

Dr. Jacobs is involved in breast, prostate and metastatic cancer imaging research. His research examines new analysis tools for magnetic resonance imaging (MRI) and PET/CT and is particularly focused on multiparametric MRI/PET/CT assessment and image analysis of radiological imaging. He holds a number of patents related to using and manipulating radiological images.

Clinical Trial Keywords

PET/CT, Whole Body Imaging, Dynamic Contrast Imaging, Diffusion Imaging, Magnetic Resonace Imaging

Clinical Trials

Pre-Operative Radiation and Veliparib for Breast Cancer

Pulsed Radiofrequency vs. Steroid Injections for Occipital Neuralgia

Selected Publications

View all on Pubmed

  1. Jacobs MA, Barker PB, Bottomley PA, Bhujwalla, Z, Bluemke DA, Proton Spectroscopic Imaging of Human Breast Cancer;a preliminary study. J. Magn. Reson. Imag. 2004; Jan;19(1):68-75
  2. Rohlfing T., Maurer, CR, Bluemke DA, Jacobs MA. Volume-Preserving Non-Rigid Registration of MR Breast Images Using an Incompressibility Constraint: An Evaluation Study. IEEE Trans Med Imaging 2003; 22; 6; 1-12
  3. Jacobs MA, Mitsias P, Soltanian-ZadehH, Santhakumar S, Ghanei A, HammoudR, Peck, DJ, Chopp M. Patel, S, Part 2. Multiparametric MRI Tissue Characterization in Clinical Stroke with Correlation to Clinical Outcome. Stroke, 2001 (32): 950-95
  4. Jacobs MA, Pan L, Macura KJ. "Whole-body diffusion-weighted and proton imaging: a review of this emerging technology for monitoring metastatic cancer." Semin Roentgenol. 2009 Apr;44(2):111-122.
  5. Ei Khouli RH, Jacobs MA, Mezban SD, Huang P, Kamel IR, Macura KJ, Bluemke DA. "Diffusion-weighted imaging improves the diagnostic accuracy of conventional 3.0-T breast MR imaging." Radiology. 2010 Jul;256(1):64-73.
  6. Glunde K, Artemov D, Penet MF, Jacobs MA, Bhujwalla ZM. "Magnetic resonance spectroscopy in metabolic and molecular imaging and diagnosis of cancer." Chem Rev. 2010 May 12;110(5):3043-3059.
  7. Jacobs MA, Stearns V, Wolff AC, Macura K, Argani P, Khouri N, Tsangaris T, Barker PB, Davidson NE, Bhujwalla ZM, Bluemke DA, Ouwerkerk R. "Multiparametric magnetic resonance imaging, spectroscopy and multinuclear ((2)(3)Na) imaging monitoring of preoperative chemotherapy for locally advanced breast cancer." Acad Radiol. 2010 Dec;17(12):1477-1485.
  8. Jacobs MA,Ouwerkerk R, Wolff AC, Gabrielson E, Warzecha H, Jeter S, Bluemke DA, Wahl R, Stearns V. Monitoring of neoadjuvant chemotherapy using multiparametric, (23)Na sodium MR, and multimodality (PET/CT/MRI) imaging in locally advanced breast cancer. Breast Cancer Res Treat. 2011 Jul;128(1):119-26
  9. Mountz JM, Yankeelov TE, Rubin DL, Buatti JM, Erikson BJ, Fennessy FM, Gillies RJ, Huang W, Jacobs MA, Kinahan PE, Laymon CM, Linden HM, Mankoff DA, Schwartz LH, Shim H, Wahl RL. Letter to cancer center directors: Progress in quantitative imaging as a means to predict and/or measure tumor response in cancer therapy trials. J Clin Oncol. 2014 Jul 1;32(19):2115-6

Activities & Honors


  • Distinguished Investigator Award, Academy of Radiology Research, 2012
  • Bronze medal winner at the American Roentgen Ray Society, Washington DC, 2008
  • Two Certificates of Merit Awards, Radiological Society of North America, 2010
  • Certificate of Merit Award, Radiological Society of North America, 2009
  • National Research Service Award Cancer Research Training Grant, 2002
  • First Place Award in Clinical Research, JHMI Oncology Center Research Day, 2000


  • American Association of Physicists in Medicine
  • American College of Radiology Imaging Network (ACRIN), By Invitation Only
  • Imaging Response Assessment Team (IRAT) Network

Professional Activities

  • American Association of Physicists in Medicine
  • American College of Radiology Imaging Network (ACRIN)
    By Invitation Only
  • Imaging Response Assessment Team (IRAT) Network
  • Chair DWI MRI Imaging. NCI – Quantitative Cancer Imaging, NCI, 2014
  • Chair/Co-chair DCE MRI Imaging. NCI – Quantitative Cancer Imaging March 5-6, NCI, 2011 - 2014
  • Co-Director, Department of Radiology and Oncology, 2005 - 2014
    IRAT committee
  • Co-Director, JHU ICMIC Imaging, Department of Radiology, 2007
    Image and Statistical Analysis
  • Co-PI, JHU Quantitative Cancer Imaging Program, 2011
  • Director, Department of Radiology and Oncology, 2014
    IRAT committee
  • Reviewer, California Breast Cancer Research Board UCLA, 2004 - 2007
  • Reviewer, Susan B. Komen Foundation for breast cancer, Dallas, 2004 - 2006
  • Reviewer, NIH/NCI, 2005 - 2010
    P01-Targeted Therapy Panel
  • Reviewer, University of Maryland, 2005
    Internal Grants
  • Reviewer, R01-NIH/NCI, 2011
    Drug Discovery and Therapy Panel
  • Reviewer, DOD for Prostate, 2012
  • Reviewer, UK Wellcome Burroughs, UK
  • Reviewer, Novitis European Grant Foundation, England
  • Reviewer, French National Evaluation Committee for Cancer translational research
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