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Matthew John Weiss, M.D.

Photo of Dr. Matthew John Weiss, M.D.

Assistant Professor of Surgery


Expertise: Bile Duct Cancer, Bile Duct Disease, Colorectal Metastases to the Liver, Distal Pancreatectomy, Gastrointestinal Cancers, Gastrointestinal Diseases, Gastrointestinal Tumors, General Surgery, Irreversible Electroporation, Klatskin Tumors, Liver Cancer, Liver Cysts, Liver Tumors, Minimally Invasive Surgery, Neuroendocrine Tumors, Pancreatic Cancer, Pancreatic Cysts, Pancreatic Disease, Surgical Oncology, Whipple Procedure more

Research Interests: Examining the outcomes following the utilization of minimally invasive and robotic surgery in pancreatic and liver surgery more

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The Johns Hopkins Hospital
Appointment Phone: 410-933-7262

600 N. Wolfe Street
Halsted 614
Baltimore, MD 21287 map
Phone: 410-614-3368
Fax: 443-992-7305


Matthew Weiss, MD, FACS, specializes in surgery for pancreatic and liver cancer, as well as benign hepatopancreatobiliary diseases, including cystic lesions of the pancreas. In addition to performing the Whipple procedure, he has particular expertise in minimally invasive pancreatic resections. Dr. Weiss' clinical interests also include colorectal metastases to the liver, hepatocellular carcinomas, intrahepatic cholangiocarcinomas, bile duct cancers (Klatskin tumors), intraductal papillary mucinous neoplasms of the pancreas, neuroendocrine tumors, and gallbladder cancers.

His research interests include the examining the outcomes following the utilization of minimally invasive and robotic surgery in pancreatic and liver surgery. He is a member of the American College of Surgeons, the Society of Surgical Oncology, the American Hepato-Pancreato-Biliary Association, and the Association for Academic Surgery. more


  • Assistant Professor of Surgery
  • Assistant Professor of Oncology

Departments / Divisions



  • MD, Jefferson Medical College of Thomas Jefferson University (2003)


  • Johns Hopkins University School of Medicine / Surgery (2010)


  • Memorial Sloan-Kettering Cancer Center / Oncology (2012)

Board Certifications

  • American Board of Surgery / Surgery (2010)

Activities & Honors


  • American Hepatopancreatobiliary Association-Member
  • American College of Surgeons-Fellow
  • Society of Surgical Oncology
  • Association for Academic Surgery-Member
  • Pancreas Club-Member

Videos & Media

Johns Hopkins Surgical Oncologists Get Personal

Learn more about Johns Hopkins cancer surgery at The surgical oncology team at Johns Hopkins gets personal as they speak about their role in treating their patients and what the Promise of Medicine means to them.

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