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Simon Best, M.D.

Simon Roderick Alfred Best, M.D.

Photo of Dr. Simon Best, M.D.

Assistant Professor of Otolaryngology - Head and Neck Surgery


Expertise: Hoarseness, Laryngeal Cancer, Laryngeal Disorders, Laryngeal Papilloma, Laryngeal Stenosis, Laryngeal Surgery, Laryngology, Otolaryngology, Recurrent Respiratory Papillomatosis , Vocal Cord Paralysis, Voice Problems more

Research Interests: Immunobiology of Recurrent Respiratory Papillomatosis (RRP); Development of novel therapeutic treatments for Recurrent Respiratory Papillomatosis (RRP); Voice and swallowing outcomes following skull base surgery more

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The Johns Hopkins Hospital
Appointment Phone: 443-997-6467

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-955-1654
Fax: 410-955-6582

Johns Hopkins Bayview Medical Center
Appointment Phone: 443-997-6467

4940 Eastern Avenue
Baltimore, MD 21224 map

Johns Hopkins Outpatient Center
Appointment Phone: 443-997-6467

601 N. Caroline St.
Baltimore, MD 21287 map
Phone: 410-955-1654
Fax: 410-955-6582


Dr. Simon Best is a fellowship-trained laryngeal surgeon whose clinical interests are focused on voice and airway disorders, including the comprehensive care of professional voice users and performers, recurrent respiratory papillomatosis (RRP), vocal cord paralysis, laryngeal cancer, precancerous vocal cord dysplasia, and laryngeal and tracheal stenosis. Dr. Best has particular expertise in laser surgery (KTP laser) for RRP, early glottic cancer, and glottis dysplasia, including office-based laser management of papillomatosis and dysplasia.

Dr. Best''s primary research focus is the immunobiology of recurrent respiratory papillomatosis (RRP) and the development of novel immunotherapies to target the underlying viral infection. This research is conducted in collaboration with the Head and Neck cancer and Cervical cancer research groups at Johns Hopkins who also study HPV-related diseases. more


  • Assistant Professor of Otolaryngology - Head and Neck Surgery

Departments / Divisions

Centers & Institutes



  • MD, Yale University School of Medicine (2006)


  • Johns Hopkins University School of Medicine / Otolaryngology (2011)


  • Massachusetts General Hospital / Otolaryngology (2012)

Board Certifications

  • American Board of Otolaryngology / Otolaryngology (2012, 2022)

Research & Publications

Selected Publications

Best SR, Friedman AD, Landau-Zemer T, Barbu AM, Burns JA, Freeman MW, Halvorsen YD, Hillman RE, Zeitels SM. The safety of bevacizumab (Avastin) for the treatment of Recurrent Respiratory Papillomatosis. In press.

Best SR, Starmer HM, Agrawal Y, Chien WW, Hillel AT, Francis HW, Tamargo RJ, Akst LM. Risk factors for vagal palsy following cerebellopontine angle surgery. Otolaryngol Head Neck Surg. 2012 Mar 23.

Starmer HM, Best SR, Agrawal Y, Chien WW, Hillel AT, Francis HW, Tamargo RJ, Akst LM. Prevalence, characteristics, and management of swallowing disorders following cerebellopontine angle surgery. Otolaryngol Head Neck Surg. 2011 Nov 18.

Best SR, Ha PK, Blanco RG, Saunders JR Jr, Zinreich ES, Levine MA, Pai SI, Walker M, Trachta J, Ulmer K, Murakami P, Thompson R, Califano JA, Messing BP. Factors associated with pharyngoesophageal stricture in patients treated with concurrent chemotherapy and radiation therapy for oropharyngeal squamous cell carcinoma. Head Neck. 2011 Dec;33(12):1727-34.

Best SR, Fakhry C. The prevalence, diagnosis, and management of voice disorders in a National Ambulatory Medical Care Survey (NAMCS) cohort. Laryngoscope. 2011 Jan;121(1):150-7.

Peng S, Best SR, Hung CF, Loyo M, Lyford-Pike S, Flint PW, Tunkel DE, Saunders JR, Wu TC, Pai SI. Characterization of human papillomavirus type 11-specific immune responses in a preclinical model. Laryngoscope. 2010 Mar;120(3):504-10.

Best SR, Peng S, Juang CM, Hung CF, Hannaman D, Saunders JR, Wu TC, Pai SI. Administration of HPV DNA vaccine via electroporation elicits the strongest CD8+ T cell immune responses compared to intramuscular injection and intradermal gene gun delivery. Vaccine 2009 Sep 4;27(40):5450-9.
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