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Hyunseok Kang, MD MPH

Instructor of Oncology
Appointment Phone


Main Location

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

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Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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  • Instructor of Oncology

Centers & Institutes

  • Sidney Kimmel Comprehensive Cancer Center


Head and Neck Cancers, Medical Oncology, Salivary Gland Tumors, Squameous Cell Carcinoma, Thyroid Cancer

Research Interests

Dr. Kang is interested in developing novel therapeutics in treatment of head and neck squamous cell carcinomas and salivary gland cancers. Dr.Kang is currently focusing on development of antibody-drug conjugates in head and neck cancers both in laboratory and clinical research settings. Dr.Kang's goal is to provide better way to understand and manage head and neck cancers through the research.


A physician-scientist with a focus on novel therapeutics in head and neck cancer, Hyu (Hyunseok) is a member of the Upper Aerodigestive Cancer Program.

Hyu's long-term goal is to develop a translational and clinical investigation program focused on head and neck cancer. In addition, he serves as an attending on the inpatient solid tumor service, establish a continuity outpatient clinic, and supervise Hematology and Oncology fellows in clinic.


  • English
  • Korean
  • Japanese


Member, American Society of Clinical Oncology

Member, American Association for Cancer Research

Member, American Society of Hematology

Member, American College of Physicians

Clinical Trial Keywords

  • Head and Neck Cancer, Antibody-Drug Conjugate, Drug Development
Additional Resources +
  • Education +


    • Yonsei University Graduate School of Public Health (Seoul) (2007)
    • Yonsei University College of Medicine (Seoul) (2002)


    • St Luke's Roosevelt Hospital Center / Internal Medicine (New York NY ) (2010)


    • Emory University School of Medicine (Atlanta GA ) (2013)


    • Oncology, American Board of Internal Medicine (2013)
    • Internal Medicine, American Board of Internal Medicine (2010)
  • Research & Publications +

    Selected Publications

    Kang H, Gillespie T, Goodman M, Brodie SA, Brandes M, Ribeiro M, Khuri FR, Ramalingam SS, Shin DM, Brandes JC. Long-term use of valproic acid in United States Veterans is associated with reduced risk of smoking related head and neck cancers. Cancer 2014;120(9):1394-1400

    Brodie SA, Li G, El-Kommos A, Kang H, Ramalingam SS, Behera M, Gandhi K, Kowalski J, Sica GL, Khuri FR, Vertino PM, Brandes JC. Class I HDACs are mediators of smoke carcinogen-induced stabilization of DNMT1 and serve as promising targets for chemoprevention of lung cancer. Cancer Prev Res (Phila). 2014;7(3):351-61

    Kim WY, Kim MJ, Moon H, Yuan P, Kim JS, Woo JK, Zhang G, Suh YA, Feng L, Behrens C, Van Pelt CS, Kang H, Lee JJ, Hong WK, Wistuba II, Lee HY. Differential impacts of insulin-like growth factor-binding protein-3 (IGFBP-3) in epithelial IGF-induced lung cancer development. Endocrinology 2011;152(6):2164-73

    Kang H, Kauh JS. Chemotherapy in the treatment of metastatic gastric cancer: Is there a global standard? Curr Treat Options Oncol 2011;12(1):96-106

    Kang H, Rha SY, Oh KW, Nam CM. Greentea consumption and stomach cancer risk: A meta-analysis. Epidemiology Health 2010; 32:e2010001

    Ahn EM, Song JI, Kang H, Park JJ, Yoo SH, Huh BR. The Symptom Expression and the Illness Behavior of North Korean Defectors: Toward an Effective Therapeutic Relationships. J Korean Acad Fam Med 2007; 28(5): 352-358

    Kim H, Kim EK, Choi ES, Kim YJ, Lee HJ, Kim JJ, Jang HS, Shim KS, Jeon SN, Kang YH, Kang H, Oh J, Cho KS, Kwon S. The Determinants of Adolescent Smoking by Sex and School Type in Korea. J Prev Med Public Health 2006;39(5):379-88

    Donato NJ, Perez M, Kang H, Siddik ZH, Ling YH, Perez-Soler R. EGF Receptor and p21waf1 Expression are Reciprocally Altered as ME-180 Cervical Carcinoma Cells Progress from High to Low Cisplatin Sensitivity. Clin Cancer Res 2000;6(1):193-202

    Clinical Trials

    Open studies

    1. A phase 1 study of IMGN289 in adult patients with EGFR-positive solid tumors.

    2. A randomized, double-blind, placebo-controlled study of chemotherapy plus cetuximab in combination with VTX-2337 in patients with recurrent or metastatic squamous cell carcinoma of the head and neck.

  • Academic Affiliations & Courses +
  • Activities & Honors +

    Professional Activities

    Board Certified in Internal Medicine, 2010-2020

    Board Certified in Medical Oncology, 2013-2023

    Board Eligible in Hematology, 2013-

  • Videos & Media +
  • Events +
  • Contact & Locations +


    Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
    401 N. Broadway
    Baltimore, MD 21231
    Phone: 410-502-0678
    Appointment Phone: 410-955-8893
    Fax: 410-955-8587
    Location Map


    • Oncology - Upper Aerodigestive Cancer

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