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Ming-Tseh Lin, M.D., Ph.D.

Photo of Dr. Ming-Tseh Lin, M.D., Ph.D.

Director, Molecular Diagnostics Laboratory, Department of Pathology

Associate Professor of Pathology

Male

Languages: English, Chinese

Expertise: Pathology

Research Interests: Internal tandem duplication of the human genome; Next-generation sequencing (NGS) platforms; Cancer biomarkers; Molecular diagnosis of solid tumors ...read more

Contact for Research Inquiries

Johns Hopkins Genomics - Molecular Diagnostic Lab
1812 Ashland Avenue
Suite 200
Baltimore, MD 21205 map

Background

Dr. Ming-Tseh Lin is an associate professor of pathology at the Johns Hopkins University School of Medicine and serves as the director of the Department of Pathology’s Molecular Diagnostics Laboratory.

A molecular pathologist, Dr. Lin is an expert in the development and validation of new assays, including the clinical application of next-generation sequencing (NGS) platforms.

Because he initially practiced as a hematologist and bone-marrow transplant specialist, Dr. Lin has a unique perspective on molecular diagnostics.

Dr. Lin earned his medical and doctoral degrees at National Taiwan University Medical School and Hospital (Taipei), where he trained in internal medicine and hematology. He completed pathology residencies at The Johns Hopkins Hospital and Albany Medical College, as well as two pathology fellowships at Hopkins.

Dr. Lin has published more than 90 academic journal articles. He is certified in molecular genetic pathology and anatomic pathology by the American Board of Pathology.

...read more

Titles

  • Director, Molecular Diagnostics Laboratory, Department of Pathology
  • Associate Professor of Pathology

Departments / Divisions

Education

Degrees

  • MD, National Taiwan University Medical School (1984)

Residencies

  • National Taiwan University Hospital / Internal Medicine (1991)
  • Albany Medical Center / Pathology (2006)
  • Johns Hopkins University School of Medicine / Pathology (2009)

Fellowships

  • National Taiwan University Hospital / Hematology (1991)
  • Johns Hopkins University School of Medicine / Pathology (2008)
  • Johns Hopkins University School of Medicine / Pathology (2010)

Board Certifications

  • American Board of Pathology / Anatomic Pathology (2009)
  • American Board of Pathology / Molecular Genetic Pathology (2011)

Research & Publications

Research Summary

Dr. Lin is an expert in the development and validation of new assays, including the clinical application of next-generation sequencing (NGS) platforms.

His current research aims to identify cancer biomarkers and design novel tandem-duplication PCR assays.

These assays will enable the detection of minimal residual disease (FLT/ITD AML) and explore the mechanisms for internal tandem duplication of the human genome.

In addition, investigators in the CLIA-certified Molecular Diagnostics Laboratory led by Dr. Lin have validated the NGS platform for mutation detection of formalin-fixed, paraffin-embedded neoplastic tissues.

Dr. Lin has previously studied the association between single- nucleotide polymorphisms and the outcomes of patients who underwent hematopoietic cell transplantation.

Selected Publications

View all on Pubmed

Belchis DA, Tseng LH, Gniadek T, Haley L, Lokhandwala p, Illei P, Gocke CD, Forde P, Brahmer J, Askin FB, Eshleman JR, Lin MT. Heterogeneity of resistance mutations detectable by next-generation sequencing in TKI-treated lung adenocarcinoma. Oncotarget. 2016;7:45237-48

Zheng G, Tseng LH, Chen G, Haley L, Illei P, Gocke CD, Eshleman JR, Lin MT. Clinical detection and categorization of uncommon and concomitant mutations involving BRAF. BMC Cancer. 2015;15:779.

Haley L, Tseng LH, Zheng G, Dudley J, Anderson DA, Azad NS, Gocke CD, Eshleman JR, Lin MT. Performance characteristics of next-generation sequencing in clinical mutation detection of colorectal cancers. Mod Pathol. 2015;28:1390-9.

Lin MT, Mosier SL, Thiess M, Beierl KF, Debeljak M, Tseng LH, Chen G, Yegnasubramanian S, Ho H, Cope L, Wheelan SJ, Gocke CD, Eshleman JR. Clinical validation of KRAS, BRAF, and EGFR mutation detection using next-generation sequencing. Am J Clin Pathol. 2014;141:856-66.

Lin MT, Storer B, Martin PJ, Tseng LH, Gooley T, Chen PJ, Hansen JA. Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation. N Engl J Med. 2003; 349:2201-10.

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