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Photo of Dr. Qian-Li Xue

Qian-Li Xue, Ph.D.

Associate Professor, Departments of Medicine, Biostatistics, Epidemiology and Center on Aging and Health, Johns Hopkins Medical Institutions
Associate Professor of Medicine

See Research on Pubmed

Male

Titles

  • Associate Professor, Departments of Medicine, Biostatistics, Epidemiology and Center on Aging and Health, Johns Hopkins Medical Institutions
  • Director of Biostatistics, Division of Geriatric Medicine and Gerontology and Center on Aging and Health
  • Associate Professor of Medicine

Centers & Institutes

  • Center on Aging and Health

Research Interests

Epidemiology of Aging, Frailty, Sarcopenia

Technology Expertise

Biostatistics

Biography

Dr. Xue is an Associate Professor of Medicine in the Division of Geriatric Medicine and Gerontology and a biostatistician and quantitative scientist focused on aging-related decline in muscle function and multisystem physiological determinants of late-life vulnerability. The breadth of Dr. Xue's impact on research on disability, frailty, systemic dysregulation and cognitive decline at the Johns Hopkins Medical Institutions is evidenced by his 86 peer reviewed publications since 2004 (47 publications over the last five years). Dr. Xue’s principal authorship of papers in the Archives of Internal Medicine, American Journal of Epidemiology, Journal of the American Geriatrics Society, and Journal of Gerontology: Medical Sciences during this span indicates his growing leadership role and national prominence in discovery on aging.

Languages

  • English
Additional Resources +
  • Education +

    Education

    • ScM, Humboldt State University, Arcata, CA, 1994
    • Ph.D, Johns Hopkins University, Baltimore, MD, 2001
    • B.S, Shanghai Ocean University, Shanghai, China, 1991
  • Research & Publications +

    Research Summary

    My research interest focuses on the natural history of frailty and its phenotypic components including sarcopenia and low physical activity. As a co-investigator of the Women’s Health and Aging Studies since 2001, I’ve been spearheading the analysis of longitudinal data relating biomarkers of inflammation, hormonal dysregulation, and micronutrient deficiencies to the development and progression of frailty. This work is providing a critical foundation for the next generation of research to delineate the synergistic effects of dysregulation in multiple biological systems on frailty. It promises to provide new biological insights and, thereby, inform the development of new interventions to treat the concurrent multisystem changes that occur in accelerated aging. In addition, I have recently developed an interest in methods to study the clinical relevance of aging-related loss of muscle mass and strength in older adults (referred to as sarcopenia), with the goal of establishing the prognostic value of intra-person variability and change in muscle mass and strength for long-term health outcomes.

    Selected Publications View all on PubMed

    Xue QL, Varadhan R. What is missing in the validation of frailty instruments? J Am Med Dir Assoc. 2014 Feb;15(2):141-2. doi: 10.1016/j.jamda.2013.11.007. Epub 2014 Jan 7. PMID: 24405640

    Xue QL, Bandeen-Roche K, Mielenz, TJ, Seplaki CL, Szanton SL, Thorpe RJ, Kalyani RR, Chaves PH, Dam TT, Ornstein K, RoyChoudhury A, Yao WL, Fried LP. Patterns of 12-Year Change in Physical Activity in Community-Dwelling Older Women: Can Modest Levels of Physical Activity Help Older Women Live Longer? Am J Epidemiol. 2012; DOI: 10.1093/aje/kws125.

    Szanton SL, Thorpe RJ, Boyd C, Tanner EK, Leff B, Agree E, Xue QL, Allen JK, Seplaki CL, Weiss C, Guralnik JM, Gitlin LN. Community aging in place, advancing better living for elders: a bio-behavioral-environmental intervention to improve function and health-related quality of life in disabled older adults. J Am Geriatr Soc. 2011 Dec;59(12):2314-20. PMID: 22091738

    Yao X, Hamilton R, Weng N-P, Xue QL, Bream JH, Tian J, Yeh S-H, Resnick B, Xu XY, Walston JD, Fried LP, Leng SX. Frailty is associated with poor vaccine-induced antibody response and increased influenza infection in community-dwelling older adults. Vaccine. 2011 Jul 12;29(31):5015-21. PMID: 21565245

    Xue QL, Walston JD, Fried LP, Beamer BA. Rate of decline in grip strength predicts the risk of falling, physical disability, and frailty: The Women’s Health and Aging Study. Arch Intern Med. 2011 Jun;171(12): 1119:1121. PMID: 21709116

    Xue QL. The Frailty Syndrome: Definition and Natural History. Clin in Geriatr Med. 2011 Feb;27(1):1-15. PMID: 21093718

    Xue QL, Beamer BA, Chaves PHM, Guralnik JM, Fried LP. Heterogeneity in rate of decline in grip, hip, and knee strength and the risk of all-cause mortality: The Women’s Health and Aging Study II. J Am Geriatr Soc. 2010 Nov;58(11):2076-84. PMID: 21054287

    Tan EJ, Tanner EK, Seeman TE, Xue QL, Rebok GW, Frick KD, Carlson MC, Wang T, Piferi RL, McGill S, Whitfield KE, Fried LP. Marketing public health through older adult volunteering: Experience Corps as a social marketing intervention. Am J Public Health. 2010 Apr;100(4):727-34. PMID: 20167888

    Rosenberg PB, Mielke MM, Xue QL, Carlson MC. Depressive Symptoms Predict Incident Cognitive Impairment in Cognitive Healthy Older Women. Am J Geriatr Psychiatry. 2010 Mar;18(3):204-11. PMID: 20224517

    Boyd CM, Ricks M, Fried LP, Guralnik JM, Xue QL, Xia J, Bandeen-Roche K. Functional Decline and Recovery of Activities of Daily Living in Hospitalized, Disabled Older Women: The Women’s Health and Aging Study I. J Am Geriatr Soc. 2009 Oct;57(10):1757-66. PMID: 19694869  

    Fried LP, Xue QL, Cappola A, Chaves PHM, Ferrucci L, Leng S, Semba RD, Varadhan R, Walston JD, Bandeen-Roche K. Multisystem physiologic abnormalities in frailty: evidence for nonlinear system biology at the macro level. J Gerontol A Biol Sci Med Sci. 2009 Oct;64(10):1049-57. PMID: 19567825

    Deal JA, Carlson MC, Xue QL, Fried LP, Chaves PH.  Anemia and 9-Year Domain-Specific Cognitive Decline in Community-Dwelling Older Women: The Women's Health and Aging Study II. J Am Geriatr Soc. 2009 Sep;57(9):1604-11. PMID: 19682133

    Leng SX, Xue QL, Tian J, Huang Y, Yeh S-H, Fried LP. Associations of Neutrophil and Monocyte Counts with Frailty in Community-Dwelling Disabled Older Women: Results from the Women's Health and Aging Study I. Exp Gerontol. 2009 Aug; 44(8):511-6. PMID: 19457449

    Stewart R, Xue QL, Masaki K, Petrovitch H, Ross GW, White LR, Launer LJ. Change in blood pressure and incident dementia: a 32-year prospective study. Hypertension. 2009 Aug; 54(2):233-40. PMID: 19564551

    Thorpe RJ, Weiss CO, Xue QL, Fried LP. Transitions among disability levels or death in African American and white older women. J Gerontol A Biol Sci Med Sci. 2009 Jun; 64(6):670-4. PMID: 19228790 

    Blaum CS, Xue QL, Tian J, Semba RD, Fried LP, Walston JD. Is hyperglycemia associated with frailty status in older women? J Am Geriatr Soc. 2009 May; 57(5):840-7. PMID: 19484839

    Cappola AR, Xue QL, Fried LP. Multiple Hormonal Deficiencies in Anabolic Hormones Are Found in Frail Older Women: The Women's Health and Aging Studies. J Gerontol A Biol Sci Med Sci. 2009 Feb; 64(2):243-8. PMID: 19182229

    Carlson MC, Xue QL, Zhou J, Fried LP. Declines and deficits in executive function precede those in memory in high-functioning older women: The Women’s Health and Aging Study II. J Gerontol A Biol Sci Med Sci. 2009 Jan; 64(1):110-7. PMID: 19182230

    Varadhan R, Seplaki CS, Xue QL, Bandeen-Roche K., Fried LP. Stimulus-response paradigm for characterizing the loss of resilience in homeostatic regulation associated with frailty. Mech Ageing Dev. 2008; 129(11):666-70. PMID: 18938195

    Xue QL, Bandeen-Roche K, Zhou J, Varadhan R, Fried LP. Initial manifestations of frailty criteria and the development of frailty phenotype in the Women’s Health and Aging Study II. J Gerontol A Biol Sci Med Sci. 2008; 63(9): 984–990. PMID: 18840805

    Xue QL, Fried LP, Glass TA, Laffan AM, Chaves PHM. Life-Space Constriction, Development of Frailty, and the Competing Risk of Mortality: The Women’s Health and Aging Study I. Am J Epidemiol. 2008; 167(2):240-48. PMID: 17906296

    Leng SX, Xue QL, Tian J, Walston JD, Fried LP. Inflammation and frailty in older women. J Am Geriatr Soc. 2007; 55(6):864-71. PMID: 17537086

    Tan EJ, Xue QL, Li T, Carlson MC, Fried LP. Volunteering: a physical activity intervention for older adults - The Experience Corps Program in Baltimore. J Urban Health. 2006; 83(5):954-69. PMID: 16763775

    Lin SM, Xue QL, Simonsick EM, Tian J, Bandeen-Roche K, Fried LP, Bathon JM, Transitions to mobility difficulty associated with lower extremity osteoarthritis (oa) in high functioning older women:  longitudinal data from the Women’s Health and Aging Study II. Arthritis Rheum. 2006; 55(2):256-63. PMID: 16583416

    Cappola AR, Xue QL, Walston JD, Leng SX, Ferrucci L, Guralnik J, Fried LP, DHEAS levels and mortality in disabled older women: The Women's Health and Aging Study I. J Gerontol A Biol Sci Med Sci. 2006;61(9):957-62. PMID: 16960027

    Bandeen-Roche, K, Xue, QL, Ferrucci, L, Walston, J, Guralnik, JM, Fried, LP, Phenotype of Frailty: characterization in the Women’s Health and Aging Studies. J Gerontol A Biol Sci Med Sci. 2006; 61(3):262-6. PMID: 16567375

    Walston, J., Xue, QL, Semba, RD, Ferrucci, L, Cappola, AR, Ricks, M, Guralnik, J, Fried, LP, Serum antioxidants, inflammation, and mortality in older women. Am J Epidemiol. 2006; 163(1):18-26. PMID: 16306311

    Stewart, R, Masaki, K., Xue, QL., Peila, R., Petrovitch, H, White, L.R., and Launer, L.J., A 32-year prospective study of change in body weight and incident dementia. The Honolulu-Asia Aging Study. Arch Neurol. 2005; 62(1):55-60. PMID: 15642850

    Blaum CS, Xue QL, Michelon E, Semba RD, and Fried LP. The association of obesity and the frailty syndrome in older women. J Am Geriatr Soc. 2005; 53(6):927-34. PMID: 15935013

    Boyd C, Xue QL, Guralnik JM, Fried LP. Hospitalization and development of dependence in activities of daily living in a cohort of disabled older women: The Women's Health and Aging Study I. J Gerontol A Biol Sci Med Sci. 2005; 60(7):888-93. PMID: 16079213

    Boyd C, Xue QL, Simpson, CF, Guralnik, JM, Fried, LP. Frailty, hospitalization and progression of disability in a cohort of disabled older women: The Women’s Health and Aging Study I. Am J Med. 2005; 118(11):1225-31. PMID: 16271906

    Chaves, PHM, Xue, QL, Guralnik, JM, Ferrucci, L, Volpato, S, Fried, LP, What constitutes normal hemoglobin concentration in community-dwelling disabled older women? J Am Geriatr Soc. 2004; 52:1-6. PMID: 15507056

    Cappola, AR, Xue, QL, Ferucci, L, Guralnik, JM, Volpato, S, and Fried, LP, Insulin-Like Growth Factor –1 and Interleukin-6 Contribute to disability and mortality in older women. J Clin Endocrinol Metab. 2003; 88(5):2019-2025. PMID: 12727948

    Xue, QL, Bandeen-Roche, K, Combining complete multivariate outcomes with incomplete covariate information: a latent class approach. Biometrics. 2002; 58: 66-76. PMID: 11890305

    Clinical Trials

    Baltimore Experience Corps Trial

    The Community Aging in Place, Advancing Better Living for Elders Trial

  • Academic Affiliations & Courses +

    Courses and Syllabi

    Statistics for Psychosocial Research
    http://courseplus.jhsph.edu/index.cfm?event=syl:syl.studentPublic.view&catalogID=17640
  • Activities & Honors +

    Honors

    1991-1994  
    California Sea Grant College Traineeship

    1995-2000   
    Tuition Scholarship, Johns Hopkins University Department of Biostatistics

    2000            
    Distinguished Student Paper Award, International Biometric Society, Eastern North American Region

    2007             
    Travel Award, Conference on Biomarkers of Aging, American Federation of Aging Research

    2010, 2011   
    Nathan Shock Scholar, the Nathan W. and Margaret T. Shock Aging Research Foundation

    Professional Activities

    2011 – 2013    
    Co-convener, The Measurement, Statistics, and Research Design Interest Group, Gerontological Society of America

    2011 – Present    
    Statistical Editor, Progress in Community Health Partnerships

  • Videos & Media +

    Lectures and Presentations

    1.  “Studying disability in subset populations: a latent variable method for combining information,” The Gerontological Society of America’s 50th Annual Scientific Meeting in Cincinnati on Nov. 16, 1997.

    2.  “A latent class model for combining information,” The American Statistical Association’s Annual Joint Statistical Meetings in Dallas, Texas on Aug. 10, 1998.

    3.  “Pseudo maximum likelihood inference for latent variable regression subject to selection bias,” International Biometric Society Eastern North American Region 2000 Spring Meeting, March 20, 2000.

    4.  “Fitting Latent Class Regression Models with Ignorably Missing Covariates,” The American Statistical Association’s Annual Joint Statistical Meetings in Atlanta, Georgia on Aug. 9, 2001.

    5.  “Comparison of population-averaged and subject-specific methods for analyzing longitudinal data: a case study,” The Gerontological Society of America’s 54th Annual Scientific Meeting in Chicago, IL on Nov. 15, 2001.

    6.  “Modeling Health Trajectories Before and After a Sentinel Event,” The American Statistical Association’s Annual Joint Statistical Meetings in San Francisco, California on Aug. 5, 2003.

    7.  “Compensatory Strategies as Preclinical Markers of IADL Disability,” The Gerontological Society of America’s 56th Annual Scientific Meeting in San Diego on Nov. 24, 2003.

    8.  “Analyzing trajectories of physical and cognitive function before or after a sentinel health event among older women,” The Gerontological Society of America’s 56th Annual Scientific Meeting in San Diego on Nov. 24, 2003.

    9.  “Type of Compensation May Identify Those Transitioning to IADL Difficulty. Invited Symposium: Opportunities for primary, secondary, and tertiary prevention of disability in older adults,” The 18th Congress of the International Association of Gerontology in Rio de Janeiro, Brazil on June 27, 2005.

    10.  “The Effect of Education on Transitions in Mobility Function in The Women’s Health and Aging Study II (WHAS II),” The Gerontological Society of America’s 58th Annual Scientific Meeting in Orlando, Florida on Nov. 19, 2005.

    11.  “Is the Association between Life Space and Incident Frailty Biased by Competing Mortality?” The Gerontological Society of America’s 59th Annual Scientific Meeting in Dallas, Texas on Nov. 19, 2006.

    12.  “Multisystem physiologic abnormalities in frailty: evidence for nonlinear system biology at the macro level,” The Gerontological Society of America’s 60th Annual Scientific Meeting in San Francisco, California on Nov. 18, 2007.

    13.  “Joint Effects of Multiple Physiological Systems on the Development of Frailty,” The Gerontological Society of America’s 61st Annual Scientific Meeting in National Harbor, Maryland on Nov. 22, 2008.

    14.  “Joint Modeling of Longitudinal and Survival Data: Assessing the Impact of Change in Lower Extremity Muscle Strength on Incident Falls, ADL, and IADL Disability in Older Women,” The Gerontological Society of America’s 62th Annual Scientific Meeting in Atlanta, Georgia on Nov. 19, 2009.

    15.  “Using Longitudinal Data to Develop Aging Phenotypes,” The Gerontological Society of America’s 62th Annual Scientific Meeting in Atlanta, Georgia on Nov. 22, 2009.

    16.  “Aging Phenotype Development: Getting Weaker vs. Being Weak,” The Gerontological Society of America’s 62th Annual Scientific Meeting in Atlanta, Georgia on Nov. 22, 2009.

    17.  “Trajectories of Change in Physical Activity and All-Cause Mortality: The Women’s Health and Aging Study (WHAS) II,” The Gerontological Society of America’s 64th Annual Scientific Meeting in Boston, Massachusetts on Nov. 22, 2011.

    18.  “Managing Missing Data in the Analysis Phase: the Stormy Seas,” Older Americans Independence Center Annual Meeting in Bethesda, Maryland on April 16, 2012.

    19.  “Overview of Key Concepts of Missing Data Issues in Gerontological Research,” The Gerontological Society of America’s 65th Annual Scientific Meeting in San Diego, California on Nov. 15, 2012.

    20.  “Is There a Causal Relationship Between Poor Sleep Quality and Frailty in Older Women?” The Gerontological Society of America’s 65th Annual Scientific Meeting in San Diego, California on Nov. 17, 2012.

    21.  “Short-Term Trajectory of Grip Strength is Predictive of Long-Term Change in Grip Strength in Older Disabled Women,” The International Conference on Sarcopenia Research in Orlando, Florida on December 7, 2012.

  • Events +
  • Contact & Locations +

    Department/Division

    • Medicine - Geriatric Medicine

    For Research Inquiries Contact

    Johns Hopkins Center on Aging and Health
    2024 E. Monument Street, Room 2-722
    Baltimore, MD 21205
    Fax: 410-614-9625

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