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Shilpa D. Kadam, Ph.D.
Research Scientist, Neuroscience
Assistant Professor of Neurology
Expertise: Neurodevelopmental Disorders
Research Interests: Epilepsy, Developmental disorders, Quantitative electroencephalograms,
Dr. Shilpa Kadam's laboratory is focused on translational neuroscience research investigating the mechanims underlying epileptogenesis in models of developmental disabilities with the goal to discover new interventional therapies. Her laboratory utilizes a novel systems neuroscience approach using in-vivo qEEG in models of developmental neurological disorders. She has successfully established a developmental model of ischemic neonatal seizures and characterised the seizures for their non-responsiveness to traditional first-line GABA agonists with the goal to both find novel alternative therapies and also prevent the occurrence of long-term co-morbidities commonly associated with the disorder. Her research has been funded by the Epilepsy Foundation and the NICHD.
Dr. Kadam completed her PhD work in the field epilepsy research in the laboratory of Dr. F. E. Dudek in 2006. This was followed by her two year post-doctoral fellowship training in the Department of Neurology at the Johns Hopkins University School of Medicine. She has a medical degree from India with three years of experience working in a Neuro-ICU at a leading tertiary center in Pune, India. Her collaborations at Hopkins have lead to novel insights in the field of Rett syndrome, autism and in-utero inflammation research.
- Research Scientist, Neuroscience
- Director of the Mouse In-vivo Electrophysiology Laboratory
- Assistant Professor of Neurology
Departments / Divisions
- Neurology - Kennedy Krieger Institute
Centers & Institutes
- B.S., Savitribai Phule Pune University (India) (1995)
- Ph.D., Colorado State University (Colorado) (2006)
Research & Publications
Dr. Kadam's doctoral research involved the study of epileptogenesis using in vivo ECOG monitoring using telemetry and in vitro slice electrophysiology in a rat model of perinatal hypoxia-ischemia. During her fellowship training at Hopkins she helped complete projects investigating the effect of neonatal stroke in a new mouse model established by the Comi laboratory on endogenous neurogenesis in the neurogenic niches of the sub-granular and sub-ventricular zones in the central nervous system.
Using the expertise gained during her pre-doctoral training in the Dudek Lab, she has established a mouse electroencephalogram (EEG) laboratory at the Kennedy Krieger Institute with capabilities of recording chronic and continuous EEGs. Dr. Kadam is interested in investigating epileptogenesis in animal models of developmental disabilities with the goal to test novel therapies. Her current research projects involve characterizing the acute electrographic seizures and investigating the evolution of refractoriness following ischemia in the neonatal period. She is also completed a study investigating the role of MeCP2 in activity dependent glutamate homeostasis in vivo.
Selected PublicationsView all on Pubmed
Kang SK, Johnston MV, Kadam SD (2015). Acute TrkB inhibition rescues phenobarbital-resistant seizures in a mouse model of neonatal ischemia. Eur J Neurosci. 42(10), 2792-804
Ammanuel S, Chan WC, Adler DA, Lakshamanan BM, Gupta SS, Ewen JB, Johnston MV, Marcus CL, Naidu S, Kadam SD (2015). Heightened Delta Power during Slow-Wave-Sleep in Patients with Rett Syndrome Associated with Poor Sleep Efficiency. PLoS One. 10(10), e0138113
Kang SK, Markowitz GJ, Kim ST, Johnston MV, Kadam SD (2015). Age- and sex-dependent susceptibility to phenobarbital-resistant neonatal seizures: role of chloride co-transporters. Front Cell Neurosci. 9, 173
Adler DA, Ammanuel S, Lei J, Dada T, Borbiev T, Johnston MV, Kadam SD, Burd I (2014). Circadian cycle-dependent EEG biomarkers of pathogenicity in adult mice following prenatal exposure to in utero inflammation. Neuroscience. 275, 305-13. Abstract
Johnston MV, Ammanuel S, O'Driscoll C, Wozniak A, Naidu S, Kadam SD (2014). Twenty-four hour quantitative-EEG and in-vivo glutamate biosensor detects activity and circadian rhythm dependent biomarkers of pathogenesis in Mecp2 null mice. Front Syst Neurosci. 8, 118. Abstract
Activities & Honors
- Epilepsy Foundation, Early career grant
- NICHD R21 , Exporatory grant
- American Epilepsy Society
- American Heart Association