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Gabriel Ghiaur, M.D., Ph.D.
Assistant Professor of Oncology
Languages: English, Romanian
Expertise: Bone Marrow Transplant, Leukemia, Medical Oncology
Research Interests: Leukemia; Bone marrow transplant; Hematopoietic Stem Cell Biology and Leukemia Stem Cells; Bone Marrow microenvironment
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The Johns Hopkins Hospital
Appointment Phone: 443-287-6997
600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Dr. Ghiaur is a physician-scientist whose primary interest is normal and malignant hematopoiesis, especially the role of the microenvironment in stem cell biology. He has distinguished himself as an outstanding laboratory-based investigator and a superior clinician. His research has translational potential in stem cell therapeutics, as well as acute leukemia.
- Assistant Professor of Oncology
Centers & Institutes
- MD; Medicine, Universitatea De Medicina Si Farmacie Carol Davila (2001)
- The Christ Hospital / Internal Medicine (2009)
- Johns Hopkins University School of Medicine / Hematology (2013)
- American Board of Internal Medicine / Hematology (2011)
- American Board of Internal Medicine / Internal Medicine (2009)
Research & Publications
Clinical Trial Keywordsleukemia, bone marrow transplant, hematologic malignancies
Selected PublicationsGhiaur G, Lee AW, Bailey JR, Cancelas JA, Zheng Y, Williams DA. Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment in vivo. Blood. 2006, Sep; 108(6):2087-2094.
Ghiaur G, Ferkowitz MJ, Milsom MD, Bailey J, Cancelas JA, Yoder MC, Williams DA. Rac1 is essential for intra embryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells. Blood. 2008 Apr 1;111(7):3313-21.
Olaru AV*, Ghiaur G*, Yamanaka S, Luvsanjav D, An F, Popescu I, Alexandrescu S, Allen S, Pawlik TM, Torbenson M, Georgiades C, Roberts LR, Gores GJ, Ferguson-Smith A, Almeida MI, Calin GA, Mezey E, Selaru FM. A microRNA downregulated in human cholangiocarcinoma controls cell cycle through multiple targets involved in the G1/S checkpoint. Hepatology. 2011, Dec;54(6):2089-98
*- these authors contribute equally to this work
Durand CM, Ghiaur G, Siliciano JD, Rabi AS, Eisele EE, Salgado M, Shan L, Lai JF, Zhang H, Margolick J, Jones RJ, Gallant JE, Ambinder RF, Siliciano R. HIV-1 DNA is detected in the bone marrow population containing CD4+ T-cells but is not found in purified CD34+ hematopoietic progenitor cells in most patients on ART. J Infect Dis. 2012 Mar;205(6):1014-8. Epub 2012 Jan 24.
Ghiaur G, Gerber J, Jones R. Cancer stem cells and minimal residual disease. Stem Cells. 2012 Jan;30(1):89-93.
Gonzalez-Nieto D, Li L, Kohler A, Ghiaur G, Ishikawa E, Sengupta A, Madhu M, Arnett J, Santho R, Dunn SK, Fishman GI, Gutstein DE, Civitelli R, Barrio LC, Gunzer M, Cancelas JA. Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors. Blood. 2012 May 31;119(22):5144-54
Ghiaur G, Gerber J, Matsui W, Jones R. Cancer stem cells Relevance to clinical transplantation. Curr Opin Oncol. 2012 Mar;24(2):170-5.
Ishikawa E, Gonzales-Nieto D, Ghiaur G, Murali B, Ficker AM, Madhu M, Dunn SK, Cancelas JA. Apr. 2012 Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9071-6.
Ghiaur G, Yegnasubramanian S, Perkins B, Gucwa J, Gerber J, and Jones RJ. Dec. 2012 Regulation of Hematopoietic Stem Cell Self-Renewal by the Microenvironments Control of Retinoic Acid Signaling. PNAS 2013
Activities & Honors
- Fellow , American Society of Hematology , 2012 - 2013
- Fellow , Maryland Stem Cell Research , 2012 - 2014
- Passano Physician Scientist Award , 2014
- American Association of Cancer Research
- American Society of Hematology