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Gabriel Ghiaur, M.D., Ph.D.

Photo of Dr. Gabriel Ghiaur, M.D., Ph.D.

Assistant Professor of Oncology

Male

Languages: English, Romanian

Expertise: Bone Marrow Transplant, Leukemia, Medical Oncology

Research Interests: Leukemia; Bone marrow transplant; Hematopoietic Stem Cell Biology and Leukemia Stem Cells; Bone Marrow microenvironment

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410-464-6641
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Locations

The Johns Hopkins Hospital
Appointment Phone: 443-287-6997

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-502-3183

Background

Dr. Ghiaur is a physician-scientist whose primary interest is normal and malignant hematopoiesis, especially the role of the microenvironment in stem cell biology. He has distinguished himself as an outstanding laboratory-based investigator and a superior clinician. His research has translational potential in stem cell therapeutics, as well as acute leukemia.

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Titles

  • Assistant Professor of Oncology

Departments / Divisions

Education

Degrees

  • MD; Medicine, Universitatea De Medicina Si Farmacie Carol Davila (2001)

Residencies

  • The Christ Hospital / Internal Medicine (2009)

Fellowships

  • Johns Hopkins University School of Medicine / Hematology (2013)

Board Certifications

  • American Board of Internal Medicine / Hematology (2011)
  • American Board of Internal Medicine / Internal Medicine (2009)

Research & Publications

Clinical Trial Keywords

leukemia, bone marrow transplant, hematologic malignancies

Selected Publications

Ghiaur G, Lee AW, Bailey JR, Cancelas JA, Zheng Y, Williams DA. Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment in vivo. Blood. 2006, Sep; 108(6):2087-2094.

Ghiaur G, Ferkowitz MJ, Milsom MD, Bailey J, Cancelas JA, Yoder MC, Williams DA. Rac1 is essential for intra embryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells. Blood. 2008 Apr 1;111(7):3313-21.

Olaru AV*, Ghiaur G*, Yamanaka S, Luvsanjav D, An F, Popescu I, Alexandrescu S, Allen S, Pawlik TM, Torbenson M, Georgiades C, Roberts LR, Gores GJ, Ferguson-Smith A, Almeida MI, Calin GA, Mezey E, Selaru FM. A microRNA downregulated in human cholangiocarcinoma controls cell cycle through multiple targets involved in the G1/S checkpoint. Hepatology. 2011, Dec;54(6):2089-98
*- these authors contribute equally to this work

Durand CM, Ghiaur G, Siliciano JD, Rabi AS, Eisele EE, Salgado M, Shan L, Lai JF, Zhang H, Margolick J, Jones RJ, Gallant JE, Ambinder RF, Siliciano R. HIV-1 DNA is detected in the bone marrow population containing CD4+ T-cells but is not found in purified CD34+ hematopoietic progenitor cells in most patients on ART. J Infect Dis. 2012 Mar;205(6):1014-8. Epub 2012 Jan 24.

Ghiaur G, Gerber J, Jones R. Cancer stem cells and minimal residual disease. Stem Cells. 2012 Jan;30(1):89-93.
Gonzalez-Nieto D, Li L, Kohler A, Ghiaur G, Ishikawa E, Sengupta A, Madhu M, Arnett J, Santho R, Dunn SK, Fishman GI, Gutstein DE, Civitelli R, Barrio LC, Gunzer M, Cancelas JA. Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors. Blood. 2012 May 31;119(22):5144-54

Ghiaur G, Gerber J, Matsui W, Jones R. Cancer stem cells Relevance to clinical transplantation. Curr Opin Oncol. 2012 Mar;24(2):170-5.

Ishikawa E, Gonzales-Nieto D, Ghiaur G, Murali B, Ficker AM, Madhu M, Dunn SK, Cancelas JA. Apr. 2012 Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9071-6.

Ghiaur G, Yegnasubramanian S, Perkins B, Gucwa J, Gerber J, and Jones RJ. Dec. 2012 Regulation of Hematopoietic Stem Cell Self-Renewal by the Microenvironments Control of Retinoic Acid Signaling. PNAS 2013


Activities & Honors

Honors

  • Fellow , American Society of Hematology , 2012 - 2013
  • Fellow , Maryland Stem Cell Research , 2012 - 2014
  • Passano Physician Scientist Award , 2014

Memberships

  • American Association of Cancer Research
  • American Society of Hematology
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