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Mark J. Soloski, Ph.D.

Photo of Dr. Mark J. Soloski, Ph.D.

Joint Appointment in Molecular Biology and Genetics

Professor of Medicine

Expertise: Lyme Disease

Research Interests: Immune mechanisms, chronic disease, Lyme disease, bacterial infection, innate immunity, non-polymorphic class Ib molecules

Background

Dr. Mark Soloski is a Professor of Medicine in the Division of Rheumatology. He studies class I histocompatibility proteins termed class Ib molecules.

Dr. Soloski received a bachelor’s degree from Manhattan College and a PhD from Rutgers University before joining the Johns Hopkins faculty. 

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Titles

  • Joint Appointment in Molecular Biology and Genetics
  • Director, Immunology Training Program, Johns Hopkins University
  • Director, Bayview Flow Cytometry Core
  • Co-Director for Basic Research, Lyme Disease Clinical Research Center
  • Professor of Medicine
  • Joint Appointment in Molecular Biology and Genetics
  • Professor of Pathology

Research & Publications

Research Summary

A general interest of the lab is the role that infection plays in setting the stage for chronic immune mediated inflammatory diseases.  Recently we have begun to investigate the human host immune response to infection with Borrelia burgdorferi the causative agent of Lyme disease. To date there is little information available as to how various cellular immune elements are mobilized following B. burgdorferi infection.  We hypothesize that the varying outcomes (cure vs. long term symptoms) that follow infection with B. burgdorferi are the result of differences in the host immune response to the infection.  We are addressing this issue by following a cohort of patients from onset of presentation with symptoms of infection through the course of disease.  This effort will attempt to identify cellular and/or molecular immune biomarkers that associate with effectiveness of bacterial clearance and/or disease pathophysiology and employs genomic, proteomic and complex immune phenotyping approaches.

A second area of interest is the identification of  immune targets in psoriatic arthritis and ankylosing spondylitis.  We are utilizing samples from a well-characterized patient cohort to identify novel autoantigens.  Our approach is to utilize state of the art proteomic and phage display based systems.

Lastly we are interested in the role of cellular elements of the immune response in controlling infection with gram-negative bacterial pathogens such as Salmonella typhimurium.  This interest is driven not only because these bacteria cause significant acute disease but also due to the etiological link between infection with Salmonella and related species with the development of chronic autoimmune disease. We utilize a mouse model and have recently focused our attention on the role of the intestinal mucosal immune compartment in controlling oral infection.  This effort has identified a new unrecognized subset of T cells residing within the epithelial barrier that expands following infection.  Current efforts are focused on understanding the recognition properties and effector function of this T cell subset and determining if an analogous population exists in the human mucosa.

 

 

 

Lab Website: Soloski Lab
Core Facility: Bayview Flow Cytometry

Technology Expertise Keywords

Flow Cytometry

Selected Publications

Soloski MJ, and Holowxzak JA. Characterization of supercoiled nucleoprotein complexes released from detergent treated vaccinia virions. J. Virol. (1981) 37:770-783.

Soloski MJ, Uhr JW, Flaherty L and Vitetta ES. Qa-2, H-2K, and H-2D alloantigens evolved from a common primordial gene. J. Exp. Med (1981) 153:1080-1093.

Soloski MJ, JJ, Uhr JW and Vitetta ES. Primary structural studies of the Qa-2 alloantigen: Implication for the evolution of the major histocpatibility complex. Nature (1982) 296:759-761.

Soloski MJ, Vernachio J, Einhorn G. and Lattimore A. Qa Gene Expression: Biosynthesis and Secretion of Qa-2 Molecules in Activated T Cells. Proc. Nat'l Acad. Sci. USA (1986) 83:2949-2953.

Stroynowski I, Soloski MJ, Hood L, and Low M. A Single Histocompatibility Qa-2 Antigen: Anchoring of the Product by a Phospholipid Tail. Cell. (1987) 50:759-768.

Soloski MJ, Hood L and Stroynowski I. Q- Region Class I Gene Expression: Identification of a Second Qa-Region Gene Encoding a Qa-2 polypeptide. Proc. Nat'l Acad. Sci. (1988) 85:3100-3104.

Imani F, and Soloski MJ. Heat shock proteins can regulate expression of the T1a region encoded class lb molecule, Qa1. Proc. Natl. Acad. Sci. (USA), (1991) 88:10475-10479.

Aldrich C, DeCloux A, Woods A, Cotter R, Soloski MJ and Forman J. Identification of a Tap dependent Leader Peptide Recognized by Alloreactive T Cells for a Class lb Antigen, (1994) Cell 79:649-658.

DeCloux A, Woods A, Cotter R, Soloski MJ and Forman J. Dominance of a single peptide bound to the class lb molecule Qa-1b. J. Immunol (1997) 158:2183-2191

Lo W-F, Woods AS, DeCloux A, Cotter R J, Metcalf ES and Soloski MJ. Molecular Mimicry Mediated by MHC Class lb Molecules Following Infection with Gram-Negative Pathogens. Nature Medicine (2000) 6:215- 218.

Davies A, Ramirez S, Liang B, Aldrich C, Lemonnier F, Jiang H, Cotter R and Soloski MJ. A Peptide from Heat Shock Protein 60 is the Dominant Peptide bound to Qa-1 in the absence of the MHC Class la Leader Sequence Peptide Qdm. J. Immunol. (2003) 170:5027-5033.

Wooden SL, Kalb SR, Cotter RJ, Soloski M.J. Cutting Edge: HLA-E Binds a Peptide Derived from the ATP-Binding Cassette Transporter Multidrug Resistance-Associated Protein 7 and Inhibits NK Cell-Mediated Lysis. J Immunol. (2005) 175:1383-7.

Eshoo, M.W., Crowder, C. C., Rebman, A. W., Rounds, M. A., Matthews, H.E., Picuri, J.M., Soloski, M. J., Ecker, D. J. Schutzer, S. E. and Aucott, J.A. (2012) Direct Molecular Detection and Genotyping of Borrelia burgdorferi from Whole Blood of Patients with Early Lyme Disease. PLoS ONE 7(5): e36825. doi:10.1371/journal.pone.0036825

Soloski, M. J., Crowder, L. A., Lahey, L. J., Wagner, C. A., Robinson, W. H., Aucott, J. N. (2014) Serum Inflammatory Mediators as Markers of Human Lyme Disease Activity. PLOSOne 6;9(4):e93243. doi: 10.1371/journal.pone.0093243.

Academic Affiliations & Courses

Courses and Syllabi

  • Principles of Immunology/GTS-1 Immunology
    Johns Hopkins Medicine
    1983
  • Graduate Immunology Course
    Johns Hopkins University
    1983
  • Immunology Graduate Program Core Course
    Johns Hopkins University School of Medicine
    2000
  • Introductory Molecular Immunology
    Johns Hopkins University
  • Innate Immunity Course
    Johns Hopkins University
    2006
  • GTS-1 Immunology (MSI)
    Perdana University Graduate School of Medicine, Kuala Lumpur, Malaysia
  • Introduction to Immunology for Rheumatology Fellows
    Johns Hopkins University
    2014
  • Foundations in Immune Recognition and Response Graduate Level Introductory Course
    Johns Hopkins University
    2014

Activities & Honors

Honors

  • Travel Award Recipient, 5th International Congress of Immunology, 1983 - 1983
  • Travel Award Recipient, 6th International Congress of Immunology, 1986 - 1986
  • Visiting Professor, nstituto de Investigaciones Biomedicas, National University of Mexico, 1998 - 1998

Memberships

  • Sigma Xi
  • American Association for the Advancement of Science
  • The American Association of Immunology
  • Society for Analytical Cytometry
  • American Society for Microbiology

Videos & Media

Lectures and Presentations

  • MHC class Ib molecules and bacterial infection
    Lecture (02/26/2004)
    Harvard School of Medicine
  • The Host Immune Response to Infection with Gram negative Enteric Pathogens
    Speaker (01/11/2006)
    Uniformed Seervices of University of Health Sciences
  • The Mucosal Immune Response to Gram Negative Enteric Bacteria
    Speaker (02/06/2006)
    Virginia Commonwealth University
  • Immune Response to Enteric Infection
    Speaker , GI Grand Rounds (04/01/2009)
    Johns Hopkins University Department of Medicine
  • Bayview Flow Cytometry Shared Resource Center
    Speaker (12/04/2009)
    Bayview Research Retreat
  • Infection and Chronic Disease: Is it the Immune Response?
    Invited Speaker (01/20/2010)
    Hunter College
  • Immunoassays in Lyme disease
    Opening Speaker (01/06/2013)
    NIST Workship on Lyme Disease
  • Research in Immunology, It Takes a Village
    Speaker , Bronx, NY (11/13/2013)
    College of Mount St. Vincent
  • T Cell Effector Responses in Tick Borne Lyme Borreliosis
    Speaker , Clinical Conundrum Series , Baltimore, MD (04/01/2013)
    Johns Hopkins School of Medicine Division of Infectious Disease
  • Lyme Disease It is complicated!
    Speaker , Seminar Series , Baltimore, MD (03/13/2015)
    Johns Hopkins University School of Medicine Department of Molecular & Comparative Pathobiology

Recent News Articles and Media Coverage

http://www.hopkinsrheumatology.org/specialty-clinics/lyme-disease-clinical-research-center/

 

http://www.hopkinsmedicine.org/news/media/releases/first_us_center_to_study_lyme_disease_launched_at_johns_hopkins_medicine

 

http://www.wsj.com/articles/the-mystery-of-chronic-lyme-disease-1436197582

 

http://baltimore.cbslocal.com/2015/07/14/maryland-is-becoming-hot-spot-for-lyme-disease/

 

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