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William S Anderson, M.A., M.D., Ph.D.
William Stanley Anderson, M.A., M.D., Ph.D.
Associate Professor of Neurosurgery
Expertise: Deep Brain Stimulation, Dystonia, Epilepsy Surgery, Essential Tremor, Intrathecal Baclofen Therapy, Neurosurgery , Parkinson's Disease , Spinal Cord Stimulation Therapy, Temporal Lobectomy, Therapeutic Neuromodulation ...read more
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The Johns Hopkins Hospital
Appointment Phone: 443-287-4561
600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Johns Hopkins Neurosurgery
Appointment Phone: 301-896-6069
4927 Auburn Avenue
Bethesda, MD 20814 map
Johns Hopkins Outpatient Center
Appointment Phone: 410-955-6406
601 N. Caroline St.
Baltimore, MD 21287 map
Dr. William Anderson is also a member of the Epilepsy Surgery team, and performs both resectional procedures such as temporal lobectomy, diagnostic procedures such as implantation of monitoring grids and depth electrodes, and therapeutic neuromodulation using vagal nerve and cortical stimulation. Procedures for pain and spasticity performed include intrathecal baclofen therapy and spinal cord stimulation therapy.
- Associate Professor of Neurosurgery
- Associate Professor of Biomedical Engineering
- MD, Johns Hopkins University School of Medicine (2001)
- Johns Hopkins University School of Medicine / Neurosurgery (2008)
- American Board of Neurological Surgery / Neurological Surgery (2012)
Research & Publications
The Anderson Laboratory focuses on the computational modeling of epilepsy as a method to understand the time and spatial evolutionary properties of seizures. Modeling methods include large array single compartment models and multicompartment simulations for the extraction of electrophysiological observables. Using these modeling tools, we explore how fast seizures spread, the spatial extent of spread, the spread of interictal spikes, and the introduction of therapies such as drug diffusion and electrical stimulation. The laboratory also explores the effects on memory encoding of theta phase specific stimulation during working memory tasks. Recordings derived from deep brain stimulation procedures are also used to learn more about motor imagery and motor planning.
Selected PublicationsView all on Pubmed
Anderson WS, Kudela P, Cho RJ, Bergey GK, Franaszczuk P. Studies of stimulus parameters for seizure disruption using neural network simulations. Biol Cybern 2007;97:173-194
Anderson WS, Azhar F, Kudela P, Bergey GK, Franaszczuk PJ. Epileptic seizures from abnormal networks: Why some seizures defy predictability. Epi Res 2012;99(3):202-213
Anderson WS, Kudela P, Weinberg S, Bergey GK, Franaszczuk PJ. Phase-dependent stimulation effects on bursting activity in a neural network cortical simulation. Epi Res 2009;84:42-55
Azhar F, Anderson WS. Prediction of single neuron spikes in sensorimotor cortex may reflect generic properties of locally connected networks. Neural Comp: 2012;24(10):2655-2677
Kudela P, Anderson WS. Computational modeling of subdural cortical stimulation: A quantitative spatiotemporal analysis of action potential initiation in a high density multicompartment model. Neuromod: Tech Neural Interface: 2015;doi: 10.1111/ner.12327
Videos & Media
Epilepsy Surgery: Jeannie's Story
After a viral brain infection left South Carolina native Jeannie with epileptic seizures that couldnt be controlled by medication, physicians from the Johns Hopkins Epilepsy Center removed the part of her brain where the seizures originated. Fifteen months later, Jeannie continues to be seizure-free and is back to enjoying life. Visit http://www.hopkinsmedicine.org/neuro.
Recent News Articles and Media Coverage
An Electrifying New Way to Fight Epilepsy, NeuroLogic (Spring 2015)
A Stimulating Approach to Alzheimer’s, Doorways to Discovery (November 2014)
New Approaches to Taming Seizures, Collaborations in Discovery (November 2011)