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Dobrila D. Rudnicki, Ph.D.

Photo of Dr. Dobrila D. Rudnicki, Ph.D.

Assistant Professor of Psychiatry and Behavioral Sciences

Research Interests: The role of RNA and RNA binding proteins in the pathogenesis of neuropsychiatric disorders, in particular Huntington disease-like 2 (HDL2), Huntington disease (HD), spinocerebellar ataxia type 2 (SCA2) and schizophrenia. more

Contact for Research Inquiries

The Johns Hopkins Hospital
600 North Wolfe Street
CMSC 8-121
Baltimore, MD 21287 map
Phone: 410-502-4654
Fax: 410-614-0013

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  • Assistant Professor of Psychiatry and Behavioral Sciences

Departments / Divisions



  • B.S., Kings College Hospital Medicine School (England) (1993)
  • Ph.D., University of Aachen (Germany) (1999)

Additional Training

National Human Genome Research Institute,, Bethesda, MD, 2001, Postdoctoral Research Fellowship; Johns Hopkins University School of Medicine, Baltimore, MD, 2006, Postdoctoral Research Fellowship

Research & Publications

Technology Expertise Keywords

Cell and mouse models of neurodegenerative diseases.

Selected Publications

Sun X., Li P.P., Zhu S., Cohen R., Marque L.O., Ross C.A., Pulst S.M., Chan H.Y., Margolis R.L., Rudnicki D.D. (2015) Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65. Sci Rep. 5:12521. doi: 10.1038/srep12521. PMC4517393

Sun, X., Marque, L., Cordner, Z., Pruitt, J.E., Bhat, M, Li, P., Kannan, G., Ladenheim, E.E., Moran, T.H., Margolis, R.L, Rudnicki, D.D. Phosphorodiamidate Morpholino Oligomers (PMOs) suppress mutant huntingtin expression and attenuate neurotoxicity. Hum. Mol. Gen., 23(23):6302-17. PMID: 25035419.

Seixas, A.I, Holmes, S.E., Takeshima, H., Pavlovich, A., Sachs, N., Pruitt, J.L., Silveira, I., Ross, C.A., Margolis, R.L. and Rudnicki, D.D. (2012) Loss of junctophilin-3 contributes to Huntington's disease-like 2 pathogenesis. Ann Neurol, 71(2):245-57. PMID: 22367996

Krause, A., Mitchell, C.L., Essop, F., Tager, S., van der Meyden, K., Temlett, J., Stevanin, G., Ross, C.A., Rudnicki, D.D., and Margolis R.L. (2015) Junctophilin 3 (JPH3) expansion mutation causing Huntington disease like 2 (HDL2) are coomon in South African patients with African Ancestry and Huntington disease phenotype. Am J Med Genet B Neuropsychiatr Genet, doi: 10.1002/ajmg.b.32332. PMID: 26079385.

Wilburn, B., Rudnicki, D.D., Zhao, J., Weitz, T.M., Cheng, Y., Xiaofeng Gu, X., Greiner, E., Park, C. S., Wang, N., Sopher, B. L., La Spada, A. R., Alex Osmand, A., Margolis, R. L., Sun, Y. E., and Yang, X. W. (2011) A Novel Antisense CAG Repeat Transcript at JPH3 Locus Mediating Expanded Polyglutamine Protein Toxicity in Huntington's Disease-Like 2 (HDL2) Mice, Neuron ,12, 427-40. PMID: 21555070

Chung, D.W., Rudnicki, D.D., Lan, Y. and Margolis, R.L. (2011) A natural antisense transcript at the Huntington's disease repeat locus regulates HTT expression. Hum Mol Gen. 20 (17), 3467-77.PMID: 21672921

Rudnicki, D.D., Pletnikova, O., Vonsattel, J.P., Ross, C.A., Margolis, R.L. (2008) A Comparison of Huntington Disease and Huntington Disease-Like 2 Neuropathology. (2008) J Neuropathol Exp Neurol. 67, 366-74. PMID: 18379432

Rudnicki, D.D., Holmes, S.E., Lin, M.W., Thornton, C.A., Ross, C.A. and Margolis, R.L. (2007) Huntington's disease-like 2 is associated with CUG repeat-containing RNA foci. Ann Neurol 61, 272-82. PMID: 17387722

Academic Affiliations & Courses

Graduate Program Affiliation

JHU Graduate Program in Cellular and Molecular Medicine (CMM)

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