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Matthias Holdhoff, M.D., Ph.D.

Photo of Dr. Matthias Holdhoff, M.D., Ph.D.

Assistant Professor of Oncology

Male

Languages: English, French, German

Expertise: Brain Cancer, Brain Tumors, Medical Oncology , Neuro-Oncology

Research Interests: Translational Research in Neuro-Oncology; Clinical Trials (therapeutic and diagnostic); Brain Tumors

Locations

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
Appointment Phone: 410-955-8964

401 N. Broadway
Baltimore, MD 21231 map
Phone: 410-955-8964

Sibley Memorial Hospital

5255 Loughboro Road NW
Washington, DC 20016 map
Phone: 202-660-6500

Background

Dr. Matthias Holdhoff is a medical oncologist at Sibley Memorial Hospital, as well as an assistant professor of oncology and neurological surgery at Johns Hopkins University School of Medicine. Dr. Holdhoff is board certified in internal medicine and oncology. He practices out of Sibley Memorial Hospital in Washington, D.C. and Johns Hopkins Sidney Kimmel Comprehensive Cancer Center in Baltimore, Md. 

Dr. Holdhoff has an expertise in brain cancer, brain tumors and neuro-oncology. He sees patients with primary brain tumors, central nervous system lymphomas and other malignancies of the central nervous system. 

Dr. Holdhoff earned his medical degree from Freie Universitat Berlin and received his doctorate degree (German Ph.D. equivalent) at Charit University Medicine Berlin. He completed a residency in internal medicine at Johns Hopkins Bayview Medical Center, followed by a fellowship in oncology at Johns Hopkins University School of Medicine. 

Dr. Holdhoff has contributed to numerous clinical trials, publications and presentations. His research is focused on translational research projects and clinical trials in neuro-oncology. As a member of the Brain Cancer Program and the Ludwig Center for Cancer Genetics and Therapeutics at Johns Hopkins, he heads a working group for the development of blood-based biomarkers in malignant gliomas, which received the ASCO Young Investigator Award in 2010. 

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Titles

  • Assistant Professor of Oncology
  • Assistant Professor of Neurosurgery
  • Joint Appointment in Medicine

Departments / Divisions

Education

Degrees

  • MD, Freie Universitat Berlin (2003)

Residencies

  • Johns Hopkins Bayview Medical Center / Internal Medicine (2007)

Fellowships

  • Johns Hopkins University School of Medicine / Oncology (2010)

Board Certifications

  • American Board of Internal Medicine / Internal Medicine (2007, 2017)
  • American Board of Internal Medicine / Oncology (2009, 2019)

Research & Publications

Selected Publications

Dr. Holdhoff's research is focused on translational research projects and clinical trials in neuro-oncology. As a member of the Brain Cancer Program and the Ludwig Center for Cancer Genetics and Therapeutics at Johns Hopkins, he heads a working group for the development of blood-based biomarkers in malignant gliomas. Dr. Holdhoff graduated from medical school at Freie Universitt Berlin and he received his doctorate degree (German PhD equivalent) at Charit University Medicine Berlin. After internal medicine training at Johns Hopkins Bayview Medical Center he completed his medical oncology fellowship and subspecialty training in neuro-oncology at the Sidney Kimmel Comprehensive Cancer Center. Dr. Holdhoff is board certified in internal medicine and medical oncology and he has a clinic for patients with primary brain tumors, CNS lymphomas and other malignancies of the central nervous system.

Journal Citations
Holdhoff M, Supko JG, Gallia GL, Hann CL, Bonekamp D, Ye X, Cao B, Olivi A, Grossman SA. Intratumoral concentrations of imatinib after oral administration in patients with glioblastoma multiforme. J. Neurooncol 2010; 97: 241-5 (Epub ahead of print Sept 19, 2009).
Holdhoff M, Schmidt K, Donehower R, Diaz LA, Jr. Analysis of Circulating Tumor DNA to Confirm Somatic KRAS Mutations. J Natl Cancer Inst 2009; 101: 1284-5.
Holdhoff M, Parsons DW, Diaz LA, Jr. Mutations of IDH1 and IDH2 are not detected in brain metastases of colorectal cancer. J Neurooncol 2009; 94: 297 (Epub ahead of print April 7).
Holdhoff M, Wung PK, Petronis JD, Couzi R. Persistent positron emission tomography-positive liver lesions after successful chemotherapy in mediastinal seminoma. J Clin Oncol. 2007; 25: 2482-4.
Holdhoff M, Kreuzer KA, Appelt C, Scholz R, Na IK, Hildebrandt B, Riess H, Jordan A, Schmidt CA, Van Etten RA, Drken B, le Coutre P. Radiosensitization of a human glioblastoma cell line by imatinib mesylate through inhibition of platelet-derived growth factor receptor. Blood Cells Mol Dis 2005; 34: 181-185.
le Coutre P, Kreuzer KA, Na IK, Schwarz M, Lupberger J, Holdhoff M, Baskaynak G, Gschaidmeier H, Platzbecker U, Ehninger G, Prejzner W, Huhn D, Schmidt CA: Imatinib in Philadelphia chromosome positive chronic phase CML patients: molecular and cytogenetic response rates and prediction of clinical outcome. Am J Hematol 2003; 73: 249-255.
le Coutre P, Kreuzer KA, Na IK, Lupberger J, Holdhoff M, Appelt, C, Schwarz M, Mller C, Gambacorti-Passerini C, Platzbecker U, Bonnet R, Ehninger G, Schmidt CA: Determination of alpha-1 acid glycoprotein in patients with Ph+ chronic myeloid leukaemia during the first 13 weeks of therapy with STI571. Blood Cells Mol Dis 2002; 28: 75-85.
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