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Peter C.M. Van Zijl, Ph.D.

Photo of Dr. Peter C.M. Van Zijl, Ph.D.

Chief, Neuroscience, Division of MR Research, Department of Radiology and Radiological Science

Professor of Radiology and Radiological Science

Research Interests: Huntington's disease; Stroke; Cancer; Alzheimer's disease; Brain function and physiology; Bioorganic biodegradable MRI contrast agents; Chemical exchange saturation transfer (CEST); Diffusion tensor imaging (DTI); Arterial spin-labeling (ASL); Susceptibility imaging; Gene expression; Cell migration; Axonal connections in the brain; Novel MRI methods; Functional magnetic resonance imaging (fMRI); Magnetic resonance imaging (MRI); Physics; Neuroscience; Neuroimaging ...read more

Background

Peter C.M. van Zijl, Ph.D., is a Professor in the Division of MR Research within the Johns Hopkins Medicine Department of Radiology and Radiological Science. He serves as Chief of the division’s Neuroscience section.

A researcher who specializes in brain imaging, Dr. van Zijl has spent his career developing novel magnetic resonance (MR) imaging and nuclear MR technologies and applying them to basic-science problems and clinical disease.

He is the Founding Director of the Johns Hopkins-affiliated F.M. Kirby Research Center for Functional Brain Imaging at the Kennedy Krieger Institute. He joined the Johns Hopkins faculty in 1992.

Dr. van Zijl earned a Ph.D. in mathematics and physics from The Netherlands’ Free University in Amsterdam, from which he also holds an M.S. in inorganic chemistry and a B.S. in chemistry.

He completed his post-doctoral work in chemistry at Carnegie Mellon University and in magnetic resonance imaging (MRI) and spectroscopy (MRS) at the NIH National Cancer Institute.

Dr. van Zijl has published more than 230 reviewed articles and serves as the principal investigator for a number of ongoing National Institutes of Health (NIH)-funded studies.

A Fellow of the International Society for Magnetic Resonance in Medicine, Dr. van Zijl is a member of many scientific advisory boards, NIH review panels and editorial boards. He also serves as the associate editor of Magnetic Resonance in Medicine.

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Titles

  • Chief, Neuroscience, Division of MR Research, Department of Radiology and Radiological Science
  • Professor of Radiology and Radiological Science
  • Professor of Biophysics and Biophysical Chemistry
  • Professor of Oncology

Departments / Divisions

Education

Additional Training

MRI and MRS, National Cancer Institute, National Institutes of Health, Bethesda, MD, 1990; Carnegie Mellon University, Pittsburgh, PA, 1987, Chemistry

Research & Publications

Research Summary

Dr. van Zijl has devoted his career to developing novel magnetic resonance imaging (MRI) and nuclear MR technologies and applying them to basic-science problems and clinical disease.

He has developed methods for MR spectroscopy (MRS) and MRS imaging; diffusion tensor imaging (DTI) and axonal mapping; physiological imaging (blood flow, blood volume and blood oxygenation); glucose metabolism measurement; and the study of magnetization-transfer processes.

Dr. van Zijl has contributed to the understanding of the blood-oxygen-level- dependent (BOLD) mechanism underlying functional MR imaging—and helped develop the capability to image endogenous signals of cellular proteins and peptides.

He is currently working to develop novel technologies for high-field MRI in humans and animals, which includes developing new biodegradable contrast agents and molecular image markers. He is also the principal investigator of a National Research Resource Center that develops MR and MRS technologies and makes them available to interested centers, scientists and clinicians.

Lab Website: Peter van Zijl Laboratory

Selected Publications

View all on Pubmed

Lim IA, Li X, Jones CK, Farrell JA, Vikram DS, van Zijl PC. "Quantitative magnetic susceptibility mapping without phase unwrapping using WASSR." Neuroimage. 2014 Feb 1;86:265-79. doi: 10.1016/j.neuroimage.2013.09.072. Epub 2013 Oct 8.

Liu G, Qin Q, Chan KW, Li Y, Bulte JW, McMahon MT, van Zijl PC, Gilad AA. "Non-invasive temperature mapping using temperature-responsive water saturation shift referencing (T-WASSR) MRI." NMR Biomed. 2014 Jan 6. doi: 10.1002/nbm.3066. [Epub ahead of print]

Lin CY, Yadav NN, Ratnakar J, Sherry AD, van Zijl PC. "In vivo imaging of paraCEST agents using frequency labeled exchange transfer MRI." Magn Reson Med. 2014 Jan;71(1):286-93. doi: 10.1002/mrm.24603. Epub 2013 Mar 6.

Hua J, Qin Q, van Zijl PC, Pekar JJ, Jones CK. "Whole-brain three-dimensional T2-weighted BOLD functional magnetic resonance imaging at 7 Tesla." Magn Reson Med. 2013 Dec 12. doi: 10.1002/mrm.25055. [Epub ahead of print]

Zeng H, Xu J, Gillen J, McMahon MT, Artemov D, Tyburn JM, Lohman JA, Mewis RE, Atkinson KD, Green GG, Duckett SB, van Zijl PC. "Optimization of SABRE for polarization of the tuberculosis drugs pyrazinamide and isoniazid." J Magn Reson. 2013 Dec;237:73-8. doi: 10.1016/j.jmr.2013.09.012. Epub 2013 Sep 29.

Activities & Honors

Honors

  • Gold Medal, 2007
  • Established Investigator Award, 1995

Memberships

  • International Society of Cerebral Blood Flow and Metabolism
  • International Society of Magnetic Resonance in Medicine

Professional Activities

  • Board of Trustees, International Society for Magnetic Resonance in Medicine, 2000 - 2004
  • Chair, Experimental Nuclear Magnetic Resonance (NMR) Conference, 2003
  • Council, International Symposium on Mixed and Augmented Reality
  • Editorial Board, Journal of Cerebral Blood Flow & Metabolism
  • Editorial Board, Journal of Magnetic Resonance
  • Editorial Board, NMR in Biomedicine
  • Executive Committee, Experimental Nuclear Magnetic Resonance Conference, 1997 - 2004
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