Dr. Gabelli's research is focused on understanding the molecular mechanisms of signal transduction and oncogenic activation in the PI3K/mTOR pathways. She is also studying the isoprenoid pathway as a target of protozoan parasitic diseases.
structural biology, drug discovery, X-ray crystallography, SAXS, protein expression and purification
Lab Website: Sandra Gabelli Laboratory
Boto AN, Xu W, Jakoncic J, Pannuri A, Romeo T, Bessman MJ, Gabelli SB, Amzel LM. Structural studies of the Nudix GDP-mannose hydrolase from E. coli reveals a new motif for mannose recognition. Proteins. 2011 Aug;79(8):2455-66.
Duong-Ly KC, Gabelli SB, Xu W, Dunn CA, Schoeffield AJ, Bessman MJ, Amzel LM. The Nudix hydrolase CDP-Chase, a CDP-choline pyrophosphatase, is an asymmetric dimer with two distinct enzymatic activities. J Bacteriol. 2011 Jul;193(13):3175-85.
Gabelli SB, Duong-Ly K, Brower ET, Amzel LM . Capitalizing on tumor genotyping: Towards the design of mutation specific inhibitors of phosphoinsitide-3-kinase. Adv Enzyme Regul. 2011;51(1):273-9.
Messing SAJ, Gabelli SB, Echeverria I, Vogel JT, Guan JC, Tan BC, Klee HJ, McCarty DR, Amzel LM. Structural Insights into Maize Viviparous14, a Key Enzyme in the Biosynthesis of the Phytohormone Abscisic Acid. Plant Cell. Sep;22(9):2970-80.
Schmidt-Kittler O, Zhu JX, Yang J, Liu G, Hendricks W, Lengauer C, Gabelli SB, Kinzler KW, Vogelstein B, Huso DL, Zhou S. PI3Kα Inhibitors That Inhibit Metastasis. Oncotarget. 2010 Sep;1(5):339-48.
Mohan S, Tse CM, Gabelli SB, Sarker R, Cha B, Fahie K, Nadella M, Zachos NC, Tu-Sekine B, Raben D, Amzel LM, Donowitz M. NHE3 activity is dependent on direct phosphoinositide binding at the N-terminus of its intracellular cytosolic region. J Biol Chem. 2010 Nov 5;285(45):34566-78.
Gabelli SB, Huang CH, Mandelker D, Schmidt-Kittler O, Vogelstein B, Amzel LM Structural Effects of Oncogenic PI3Kalpha Mutations. Curr Top Microbiol Immunol. 2010;347:43-53
Barrila J, Gabelli SB, Bacha U, Amzel LM, Freire E. Mutation of Asn28 disrupts the dimerization and enzymatic activity of SARS 3CL(pro). Biochemistry. 2010 May 25;49(20):4308-17.
Gabelli SB, Mandelker D, Schmidt-Kittler O, Vogelstein B, Amzel LM. Somatic mutations in PI3Kalpha: Structural basis for enzyme activation and drug design. Biochim Biophys Acta. 2010 Mar;1804(3):533-40.
Huang CH, Gabelli SB, Oldfield E, Amzel LM. Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer Proteins. Proteins. 2010 Mar;78(4):888-99.