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Kristin Bigos, Ph.D.

Photo of Dr. Kristin Bigos, Ph.D.

Assistant Professor of Medicine

Background

Dr. Kristin Bigos is an assistant professor of medicine and of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine. Her research focuses on brain physiology and brain disorders.

Her team currently uses pharmacogenetics and functional neuroimaging to explore novel drug targets and potential therapeutic agents for brain disorders.

Dr. Bigos received her B.S. in premedicine from the Pennsylvania State University. She earned her Ph.D. in clinical pharmaceutical sciences from the University of Pittsburg. She completed a post-doctoral fellowship in the clinical brain disorders branch of the Intramural Research Program of the National Institute of Mental Health under Dr. Daniel Weinberger. 

She is an investigator in the division of clinical pharmacology at the Lieber Institute for Brain Development. She has been recognized with several honors, including a National Institutes of Health Fellows Award for Research Excellence for her research on the functional neuroimaging of glutamate and calcium signaling pathways.

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Titles

  • Assistant Professor of Medicine
  • Assistant Professor of Psychiatry and Behavioral Sciences

Education

Degrees

  • B.S., Pennsylvania State University (Pennsylvania) (2001)
  • Ph.D., University of Pittsburgh (Pennsylvania) (2007)

Additional Training

National Institute of Mental Health, Bethesda, MD, 2011, Clinical Brain Disorders Branch

Research & Publications

Research Summary

Dr. Bigos’ research uses pharmacogenetics and functional neuroimaging to identify novel drug targets, test potential therapeutic agents and understand the variability in response to psychiatric medications.

Clinical Trials

Functional Neuroimaging of Nimodipine in Healthy Adults

Selected Publications

Apud JA, Zhang F, Decot H, Bigos KL, Wienberger DR. "Genetic variation in KCNH2 associated with expression in brain of a unique herg isoform modulates treatment response in patients with schizophrenia." Am J Psychiatry. 2012; 169:725-734.

Bigos KL, Bies RR, Pollock BG, Lowy JJ, Zhang F, Weinberger DR. "Genetic variation in CYP3A43 explains racial difference in olanzapine clearance." Molecular Psychiatry. 2011;16:620-625.

Bigos KL, Mattay VS, Callicott JH, Straub RE, Vakkalanka R, Kolachana B, Hyde TM, Lipska BK, Kleinman JE, Weinberger DR. "Genetic variation in CACNA1C affects brain circuitries related to mental illness." Arch Gen Psychiatry. 2010;67(9):939-45.

Bigos KL, Pollock BG, Aizenstein HJ, Fisher PM, Bies RR, Hariri AR. "Acute 5-HT reuptake blockade poteniates human amygdala reactivity." Neuropsychopharmacology. 2008;33:3221:3225.

Bigos KL, Pollock BG, Coley KC, Marder SR, Miller DD, Kirshner MA, Bies RR. "Sex, race, and smoking impact on olanzapine exposure." J Clin Pharmacol. 2008;48(2):157-165.

Activities & Honors

Honors

  • Fellows Award for Research Excellence, National Institutes of Health
  • Pharmaceutical Sciences Graduate Student Excellence Award, University of Pittsburgh School of Pharmacy, 2005
  • Ruth L. Kirschstein National Research Service Award, National Institutes of Health
  • Fellowship, American Foundation for Pharmaceutical Education
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