Dr. Kanakry’s clinical research is focused on the investigation of the relationship between viruses and lymphomas. Subsets of many high-grade lymphomas are associated with Epstein-Barr virus, particularly in immunocompromised patients such as those with human immunodeficiency virus (HIV). With rare exception, the presence of Epstein-Barr virus in these tumors is not currently used clinically to improve diagnostic, prognostic, or therapeutic approaches. A major aim of Dr. Kanakry’s research is to identify virus-related biomarkers in the blood that can be used for risk-stratification and response assessment in lymphoma, with the hope that this will translate to lower treatment-related toxicities and higher cure rates for these patients. Dr. Kanakry is also currently investigating the use of virus-targeted therapies for the treatment of patients with virus-associated lymphomas and other cancers.
Kanakry JA, Kasamon YL, Gocke C, Tsai H, Davis-Sproul J, Ghosh N, Symons, H, Bolanos-Meade J, Gladstone DE, Swinnen LJ, Luznik L, Fuchs EJ, Jones RJ, Ambinder RF. Outcomes of related donor HLA-identical or HLA-haploidentical allogeneic blood or marrow transplantation for peripheral T-cell lymphoma. Biology of Blood and Marrow Transplantation.2013; 19(4):602-6.
Kanakry JA, Li H, Gellert LL, Lemas MV, Hsieh W, Hong F, Tan KL, Gascoyne RD, Gordon LI, Fisher RI, Bartlett NL, Stiff P, Cheson BD, Advani R, Miller, TP, Kahl BS, Horning SJ, Ambinder RF. Plasma Epstein-Barr virus DNA predicts outcome in advanced Hodgkin lymphoma: correlative analysis from a large North American co-operative group trial. Blood. 2013; 121(18):3547-53. [Plenary paper]
Kanakry JA, Kasamon YL, Bolanos-Meade J, Borrello IM, Brodsky RA, Fuchs EJ, Ghosh N, Gladstone DE, Gocke CD, Huff CA, Kanakry CG, Luznik L, Matsui W, Mogri HJ, Swinnen LJ, Symons HJ, Jones RJ, Ambinder RF. Absence of post-transplantation lymphoproliferative disorder after allogeneic blood or marrow transplantation using post-transplantation cyclophosphamide as graft-versus-host disease prophylaxis. Biology of Blood and Marrow Transplantation. 2013 Oct; 19(10):1514-7.
Kanakry JA andAmbinder RF. EBV Related Lymphomas: New Approaches to Treatment. Current Treatment Options in Oncology. 2013; 14(2):224-36.
Kanakry JA and Ambinder RF. Old variables, new value: A refined IPI for DLBCL. Blood. 2014
Yates JA, Zakai N, Griffith R, Wing E, Schiffman FJ. Multicentric Castleman disease, Kaposi sarcoma, hemophagocytic syndrome and a novel HHV8-lymphoproliferative disorder. AIDS Reader. 2007; 17(12):596-8.
Kanakry JA and Gladstone DE. Maintaining hemostasis in acquired von Willebrand syndrome: a review of intravenous immunoglobulin and the important of rituximab dose scheduling. Transfusion. 2013 Aug;53(8):1730-5.
Agrawal, M., Kanakry, J., Arnold, C., Suzman, D., Mathieu, L., Kasamon, Y., Gladstone, D., Ambinder, R., Ghosh, N. Sustained remission and reversal of end-organ dysfunction in a patient with anaplastic myeloma. Annals of Hematology. 2013 Nov 15. PMID: 24232305. Epub ahead of print.
Kanakry JA and Ambinder RF. Virus-Associated Lymphoma. In: Hoffman: Hematology: Basic Principles and Practice. 6th edition. Chapter 82. 2012. Elsevier Press.
Kanakry JA, Kasamon YL, and Ambinder RF. Post-Transplant Lymphomas. In: Younes, A. and Coiffier, B. Lymphoma: Diagnosis and Treatment. 1st edition, Chapter 17. 2013. Humana Press.
Kanakry JA. and Ambinder RF. Human Herpesviruses: Malignant Lymphoma. In: Kaslow, R., Stanberry, L., and LeDuc, J. Viral Infections in Humans: Epidemiology and Control. 5th edition. Chapter 38. 2013. Springer.
Kanakry JA and Ambinder RF. Epstein-Barr virus Infection. In: Applebaum, F., Forman, S., Negrin, R., and Blume, K. Thomas’ Hematopoietic Cell Transplantation. 5th edition. Wiley-Blackwell Publishing.