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Nicholas A. Flavahan, M.Sc., Ph.D.

Photo of Dr. Nicholas A. Flavahan, M.Sc., Ph.D.

Edward D. Miller, M.D., Professor of Anesthesiology Research

Professor of Anesthesiology and Critical Care Medicine

Research Interests: Vascular disease

Contact for Research Inquiries

The Johns Hopkins University School of Medicine
720 Rutland Ave
Ross 372
Baltimore, MD 21205 map
Phone: 410-502-6738
Fax: 410-502-7007

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Background

Dr. Nicholas Flavahan is a professor of anesthesiology and critical care medicine at the Johns Hopkins University School of Medicine. He is the inaugural Edward D. Miller, M.D., Professor of Anesthesiology Research and serves as director of research and vice chair of the Department of Anesthesiology and Critical Care Medicine.

Dr. Flavahan’s research focuses on elucidating the cellular interactions and subcellular signaling pathways that control normal vascular function and regulate the initiation of vascular disease. Among many firsts, he discovered the molecular mechanisms underlying cold-induced vasoconstriction in the cutaneous circulation and its contribution to normal physiology and vascular disease.

He has had a dramatic influence on the research activity of the Department of Anesthesiology and Critical Care Medicine, revamping the infrastructure for conducting basic clinical and translational research, redefining mechanisms for scientific interaction, reorganizing and facilitating the grant submission process, and providing structured and transparent mechanisms for young trainees and junior faculty to achieve independence and career advancement.

He obtained his Ph.D. in cardiovascular physiology and pharmacology in 1983 at the University of Glasgow in Scotland. He then joined the Mayo Clinic in Rochester, Minnesota, as a Mayo Foundation senior research fellow and was appointed assistant professor of pharmacology at the Mayo Clinic in 1987. Dr. Flavahan stayed at the Mayo Clinic until 1989 when he joined the faculty of Johns Hopkins University as an assistant professor of medicine and was promoted to associate professor of medicine in 1991. In 1997, he was recruited to The Ohio State University to help create the Heart and Lung Research Institute where he was deputy director of the institute as well as professor of internal medicine, physiology and cell biology. In September of 2006, Dr. Flavahan returned to Johns Hopkins University where he was appointed professor, director of research and vice chair of the Department of Anesthesiology and Critical Care Medicine.

Dr. Flavahan is one of the world's top molecular vascular pharmacologists. He has published more than 100 peer-reviewed manuscripts and has been funded continuously by the NIH for more than 20 years. Dr. Flavahan has also been an effective teacher and mentor, with many of trainees advancing to leadership positions in the pharmaceutical industry and academic medicine.

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Titles

  • Edward D. Miller, M.D., Professor of Anesthesiology Research
  • Director, Research Division, Department of Anesthesiology and Critical Care Medicine
  • Vice Chair, Department of Anesthesiology and Critical Care Medicine
  • Professor of Anesthesiology and Critical Care Medicine

Education

Degrees

  • B.Sc., University of Glasgow (Scotland) (1978)
  • M.Sc., University of Glasgow (Scotland) (1979)
  • Ph.D., University of Glasgow (Scotland) (1983)

Additional Training

University of Glasgow, Glasgow, Scotland, 1983, Research Fellowship; Mayo Clinic, Rochester, MN, 1986, Research Fellowship

Research & Publications

Research Summary

The primary goal of Dr. Flavahan’s research is to elucidate the cellular interactions and subcellular signaling pathways that control normal vascular function and regulate the initiation of vascular disease. To investigate vascular function, Dr. Flavahan’s methods range from biochemical or molecular analyses of cellular mediators and cell signaling mechanisms in cultured vascular cells to physiological assessment and fluorescent microscopic imaging of signaling systems in isolated blood vessels.

Lab

Dr. Flavahan and his team are pursuing several major projects that focus on understanding 1) the mechanisms underlying mechanotransduction in cultured and native smooth muscle and its role in vascular disease, including hypertension; 2) the role of reactive oxygen species (ROS) in the physiological control of the vascular system; 3) mechanisms contributing to occlusive vascular diseases (e.g., scleroderma, arteriosclerosis); 4) mechanisms underlying the abnormal vasoreactivity of Raynaud’s phenomenon (cold-induced vasospasm) and scleroderma; 5) mechanisms regulating the life cycle of vascular cells, including development, differentiation, and apoptosis; and 6) the role of the sympathetic nervous system and x-adrenergic receptors in vascular function and disease.

Dr. Nicholas Flavahan's Lab

Selected Publications

  1. Flavahan, NA. "Regulation of vascular reactivity in Scleroderma: new insights into Raynaud's phenomenon." Rheum Dis Clin N Am. 34(1):81–7, 2008.
  2. Thompson-Torgerson CS, Holowatz LA, Flavahan NA, Kenney WL. "Cold-induced cutaneous vasoconstriction is mediated by Rho kinase in vivo in human skin." Am J Physiol Heart Circ Physiol. 292(4):H1700–5, 2007.
  3. Eid AH, Maiti K, Mitra S, Chotani MA, Flavahan S, Bailey SR, Thompson-Torgerson CS, Flavahan NA. "Estrogen increases smooth muscle expression of alpha2C-adrenoceptors and cold-induced constriction of cutaneous arteries." Am J Physiol Heart Circ Physiol. 293(3):H1955–61, 2007.
  4. Thompson-Torgerson CS, Holowatz LA, Flavahan NA, Kenney WL. "Rho kinase-mediated cold-induced cutaneous vasoconstriction is augmented in aged human skin." Am J Physiol Heart Circ Physiol. 293(1):H30–6, 2007.
  5. Bailey SR, Mitra S, Flavahan S, Bergdall VK, Flavahan NA. "In vivo endothelial denudation disrupts smooth muscle caveolae and differentially impairs agonist-induced constriction in small arteries." J Cardiovasc Pharmacol. 49(4):183-90, 2007.

Activities & Honors

Professional Activities

  • Chair, Johns Hopkins Vascular Medicine Research Initiative, 2007
    Steering Committee
  • Chair, Department of Anesthesiology and Critical Care Medicine, 2007
    Research Committee
  • Director of Research, Department of Anesthesiology and Critical Care Medicine, 2006
  • Guest Editor, Arteriosclerosis, Thrombosis and Vascular Biology
  • Reviewer, American Journal of Physiology
  • Reviewer, Arteriosclerosis Thrombosis & Vascular Biology
  • Reviewer, British Journal of Pharmacology
  • Reviewer, Cardiovascular Research
  • Reviewer, Circulation
  • Reviewer, Circulation Research
  • Reviewer, FASEB Journal
  • Reviewer, Journal of Applied Physiology
  • Reviewer, Journal of Clinical Investigation
  • Reviewer, Journal of Pharmacology and Experimental Therapeutics
  • Reviewer, New England Journal of Medicine
  • Reviewer, Proceedings of National Academy of Sciences
  • Vice Chair, Department of Anesthesiology and Critical Care Medicine, 2006
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