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Miroslaw Janowski, M.A., M.D., Ph.D.

Photo of Dr. Miroslaw Janowski, M.A., M.D., Ph.D.

Assistant Professor of Radiology and Radiological Science

Research Interests: Magnetic resonance imaging, Stem cell tracking

Background

Titles

  • Assistant Professor of Radiology and Radiological Science

Departments / Divisions

Education

Degrees

  • M.D., Akad Medicine Warszawie - Warszawa - (Poland) (2001)
  • M.A., University of Warsaw (Poland) (2001)
  • Ph.D., Polish Academy of Science (Poland) (2010)

Research & Publications

Lab

The Janowski lab focuses on the exploration and optimization of stem cell transplantation through various routes of cell delivery, investigates the navigation of stem cells to appropriate brain regions, and studies the graft-host interaction, including immunological aspects. Janowski is especially interested in the translational aspects of stem cell therapy with the use of large animals to develop clinic-ready stem cell delivery protocols. His lab investigates magnetic forces and genetic engineering methods for cell guidance purposes, and utilizes advanced magnetic resonance imaging (MRI) techniques to track stem cells after transplantation.

Stem cell transplantation is a very promising strategy to overcome the limitations of current treatment methods. However, the routes and procedures of transplantation are not yet optimized, especially for minimally invasive routes, such as intravascular or intraventricular. Despite the promising preclinical results, stem cell therapy has proven to be difficult to translate into routine clinical practice. The major problem is in the interpretation of the outcomes of stem cell therapy, as there is a lack of accurate information about the fate of the cells in vivo. Concomitantly, the development of new pharmaceuticals requires an assessment of drug kinetics—the gold standard for the evaluation of treatment efficacy. The outcomes of surgery, in turn, are typically confirmed by post-operative imaging. These methods allow for a conclusive assessment of pharmacological or surgical treatment efficacy. Thus, the issue of following cell fate and the interaction between graft and host is crucial, and Janowski’s lab explores these areas, as well as a broad spectrum of stem cell-based regenerative medicine approaches.

Technology Expertise Keywords

Magnetic resonance imaging, Stem cell tracking

Selected Publications

View all on Pubmed

  1. Mohandas G, Oskolkov N, McMahon MT, Walczak P, Janowski M. Porous tantalum and tantalum oxide nanoparticles for regenerative medicine. Acta Neurobiol Exp (Wars). 2014;74(2):188-96. PMID: 24993628 [PubMed - in process]
  2. Janowski M, Walczak P, Kropiwnicki T, Jurkiewicz E, Domanska-Janik K, Bulte JW, Lukomska B, Roszkowski M. Long-term MRI cell tracking after intraventricular delivery in a patient with global cerebral ischemia and prospects for magnetic navigation of stem cells within the CSF. PLoS One. 2014 Jun 11;9(2):e97631. doi: 10.1371/journal.pone.0097631. eCollection 2014. PMID: 24919061 [PubMed - in process]
  3. Barczewska M, Wojtkiewicz J, Habich A, Janowski M, Adamiak Z, Holak P, Matyjasik H, Bulte JW, Maksymowicz W, Walczak P. MR monitoring of minimally invasive delivery of mesenchymal stem cells into the porcine intervertebral disc. PLoS One. 2013 Sep 13;8(9):e74658. doi: 10.1371/journal.pone.0074658. eCollection 2013. PMID: 24058619
  4. Jablonska A, Janowski M, Lukomska B. Different methods of immunosuppresion do not prolong the survival of human cord blood-derived neural stem cells transplanted into focal brain-injured immunocompetent rats. Acta Neurobiol Exp (Wars). 2013;73(1):88-101. PMID: 23595286
  5. Nowakowski A, Andrzejewska A, Janowski M, Walczak P, Lukomska B. Genetic engineering of stem cells for enhanced therapy. Acta Neurobiol Exp (Wars). 2013;73(1):1-18. Review. PMID: 23595280
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