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Miroslaw Janowski, M.A., M.D., Ph.D.

Photo of Dr. Miroslaw Janowski, M.A., M.D., Ph.D.

Associate Professor of Radiology and Radiological Science

Research Interests: Stem cells, brain, stroke, myopia, intra-arterial

Contact for Research Inquiries

Miller Research Building, Rm 649
733 N Broadway
Baltimore, MD 21205 map

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Background

Dr Janowski completed residency in neurosurgery in 2009 at the Medical University of Warsaw, Poland in 2009, and after defending his PhD thesis in 2010 at the Mossakowski Medical Research Centre, Polish Academy of Sciences, he moved to the United States in 2011 and joined the Department of Radiology and Institute for Cell Engineering at the Johns Hopkins University as a post-doctoral fellow. In 2012 he has been promoted to the level of Assistant Professor and in 2016 to the level of Associate Professor.  

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Titles

  • Associate Professor of Radiology and Radiological Science

Departments / Divisions

Education

Degrees

  • M.D., Akad Medicine Warszawie - Warszawa - (Poland) (2001)
  • M.A., University of Warsaw (Poland) (2001)
  • Ph.D., Polish Academy of Science (Poland) (2010)

Additional Training

  • Polish Board Certification for Neurosurgery (equivalent of FRCS according to Annex V of Directive 2005/36/EC) (2009)
  • General Medical Council – Specialist registration in neurosurgery with license to practice in UK (GMC reference number: 7078571) (2010)

Research & Publications

Research Summary

The Janowski lab centers on the routes of delivery of therapeutic agents to the brain as well as explores new applications for stem cells. 

He pursues a research on the use of intra-arterial and intraventricular routes to provide therapeutic agents at the high-dose to the central nervous system. The employment of body fluids such as CSF and blood makes the procedures less invasive. The major contribution of dr Janowski lab lies within application of MRI guidance to intra-arterial and intra-ventricular procedures, which facilitated the precision and predictability. He is particularly devoted to real-time MRI guidance of brain infusions using novel contrast mechanisms such as chemical exchange saturation transfer (CEST), which allows for multicolor interventional neuroradiology. 

Beyond the research on delivery routes, Dr. Janowski explores the new applications for stem cell research. He is involved in the use of stem cells for degenerative disc disease. Dr Janowski has also pioneered the idea of using stem cells to prevent progression of myopia, a worldwide pandemic that is expected soon to be the most frequent cause of blindness, and is establishing research on myopia in his laboratory.

 

Lab

Dr. Janowski's laboratory is located in the Institute for Cellular Engineering (ICE) in the MRB building, consisting of 500 sq. ft. of fully equipped general laboratory space for molecular biology, biochemistry and tissue processing, and, a 250 sq. ft. tissue culture room with four incubators for ambient and low oxygen environment, inverted microscope, automated cell counter and high end Zeiss Observer.

Z1 microscope equipped with motorized scanning stage, ApoTome and ORCA-Flash 4.0 CMOS camera (Hamamatsu). There is also available a Dell workstation dedicated to image processing (Matlab, Amira) and a stereotaxic apparatus. The P.I. has an office in the MRB (ICE) building and an adjacent lab with six desks for postdocs, visitors, and students with total office/desk space of about 500 sq. ft. 

Dr Janowski has also an access to the start-of-the art imaging equipment including small animal and clinical scanners, as well as small and large animal facilities. 

 

Technology Expertise Keywords

Magnetic resonance imaging, Stem cell tracking

Selected Publications

View all on Pubmed

"Real-time MRI for monitoring and prediction of engineered stem cell delivery to the CNS" January 2015, Zagreb Croatia: GlowBrain Workshop "Visualization of molecular markers in the brain".

"Novel approaches to in vivo stem cell imaging" February 2015, Kuopio, Finland: Stem Cell Day

"Real-Time MRI of Stem Cell Delivery for Precise Therapeutic Transplantations to the Central Nervous System" March 2015, Pusan, South Korea: BIT's 8th Annual World Congress of Regeneration Medicine & Stem Cell

"Multi-center, double-blinded, randomized preclinical trials in stroke – a concept" May 2015, Warsaw, Poland: International Symposium "Stem Cells for Stroke and Beyond…".

"Dynamic susceptibility contrast MRI for predicting and monitoring of intra-arterial delivery of therapeutic agents" April 2016, Warsaw, Poland: New Horizons in Medical Imaging and Cell Therapy.

"Superparamagnetic iron oxide nanoparticles for real-time MRI of intra-arterial, predicted and precise drug and stem cell delivery" May 2016, Singapore: EMN Meeting on Nanoparticles.

Academic Affiliations & Courses

Courses and Syllabi

  • Medical Student
    Teaching at the bedside, in the operating theatre and seminars
    Medical University of Warsaw
    2002 - 2011
  • Neurosurgical Residents
    Complex management of neurosurgical patients including decision making and surgery supervision
    Medical University of Warsaw
    2006 - 2011
  • Physiotherapy Students
    Lectures and Seminars
    Medical University of Warsaw
    2010 - 2011
  • Regenerative Medicine, Graduate Course
    Lecturer
    Johns Hopkins University
    2014

Activities & Honors

Honors

  • Travel Fellowship, ScanBalt Campus Network Regenerative Medicine, 2006
  • Travel Fellowship, Foundation for Polish Science (Kyoto, Japan), 2007
  • Travel Fellowship, International Brain Research Organization (Melbourne, Australia), 2007
  • Travel Fellowship, International Society on Neural Transplantation and Repair (Freiburg, Germany), 2008
  • Travel Fellowship, Massachusetts General Hospital – Karolinska Institute – Cell Press (Boston, USA), 2009
  • Cover Figure, Stem Cells and Development Journal; Janowski M, Walczak P, Date I “Intravenous route of cell delivery for treatment of neurological disorders. A meta-analysis of preclinical results.”, 2010
  • Summa Cum Laude, Award for Outstanding PhD Thesis Defense, 2010
  • Young Investigator Award, Mossakowski Medical Research Centre, 2010
  • J. Sniadecki Prize, Polish Academy of Sciences in the field of Medical Research in Poland, 2010

Memberships

  • International Society for Magnetic Resonance in Medicine, 2011
  • World Molecular Imaging Society, 2012

Videos & Media

The Vascular Biology Program at Johns Hopkins' Institute for Cell Engineering

Recent News Articles and Media Coverage

“America’s Vision Problem” by Miroslaw Janowski, Piotr Walczak and James Handa in Congress Blog: The Hills Forum For Lawmakers And Policy Professionals: http://thehill.com/blogs/congress-blog/healthcare/248262-americas-vision-problem

http://www.hopkinsmedicine.org/news/media/releases/mri_guidance_shows_promise_in_delivering_stem_cell_therapies

http://medresearch.tumblr.com/post/151161872826/mri-guidance-shows-promise-in-delivering-stem-cell

http://www.biosciencetechnology.com/news/2016/09/mri-guidance-shows-promise-delivering-stem-cell-therapies

https://www.dotmed.com/news/story/32954

http://www.bizindia.net/mri-guidance-shows-promise-in-delivering-stem-cell-therapies/

http://www.news-line.com/PX_news25550_

http://myinforms.com/en-us/a/41253454-real-time-mri-guidance-could-help-target-and-deliver-stem-cell-therapies/

http://www.news-medical.net/news/20160914/Real-time-MRI-guidance-could-help-target-and-deliver-stem-cell-therapies.aspx

http://medicalxpress.com/news/2016-09-mri-guidance-stem-cell-therapies.html

https://www.mdtmag.com/article/2016/09/mri-guidance-shows-promise-delivering-stem-cell-therapies

http://www.pressreleasepoint.com/mri-guidance-shows-promise-delivering-stem-cell-therapies

https://www.sciencedaily.com/releases/2016/09/160914095606.htm

http://www.publicnow.com/view/F7B162400A5E4C0E145A2EBF32E6DE5FE0E1500E

 

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