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Andrew Jon Holland, M.A., Ph.D.

Photo of Dr. Andrew Jon Holland, M.A., Ph.D.

Assistant Professor of Molecular Biology and Genetics

Research Interests: Cell cycle control; Genome instability; Chromosome segregation.

Background

Dr. Andrew J. Holland is an assistant professor of molecular biology and genetics at the Johns Hopkins University School of Medicine. He has a secondary appointment in oncology.

Dr. Holland’s research focuses on the molecular mechanisms that control accurate chromosome distribution and the role of mitotic errors—those related to cell division—in human health and disease. A key objective of his research is to develop cell and animal-based models to study the role of mitotic defects in genome instability and tumorigenesis.

The Holland Lab was awarded research grants from the Leukemia Research Foundation and the W.W. Smith Charitable Trust in 2013, the year Dr. Holland joined the Johns Hopkins faculty.

Dr. Holland earned both his Ph.D. and M.Res. at the U.K.’s University of Manchester. He completed a postdoctoral fellowship at the Ludwig Institute for Cancer Research at the University of California, San Diego.

Dr. Holland has published more than 20 journal articles and delivered many invited lectures. His honors include a 2013 March of Dimes Basil O''Connor Starter Research Award and a 2006 Wellcome Trust Value in People (VIP) Award. He is a member of professional organizations that include the American Society for Cell Biology, American Association for Cancer Research, and American Association for the Advancement of Science.

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Titles

  • Assistant Professor of Molecular Biology and Genetics
  • Assistant Professor of Oncology

Education

Degrees

  • M.A., University of Cambridge (United Kingdom) (2002)
  • Ph.D., University of Manchester (United Kingdom) (2006)

Additional Training

Ludwig Institute for Cancer Research, San Diego, CA, 2013

Research & Publications

Research Summary

Cell division is a fundamental process forming the basis for life itself. Each time a cell divides, it makes a complete copy of its entire genome and segregates this genome such that both daughter cells receive all the genetic information required for further growth and development.

Errors in the distribution of chromosomes during mitosis lead to the production of cells with an abnormal chromosome content, which in early development lead to lethal growth defects and may later contribute to the development of cancer.

The Holland Lab is interested in the molecular mechanisms that control accurate chromosome distribution and the role that mitotic errors play in human health and disease.

The lab utilizes a combination of chemical biology, biochemistry, cell biology and genetically engineered mice to study pathways involved in mitosis and their effect on cell and organism physiology.

A major focus of the group is to develop cell and animal-based models to study the role of cell division defects in genome instability and tumorigenesis.

Lab Website: Holland Lab

Selected Publications

View all on Pubmed

Kim Y*, Holland AJ*, Lan W, Cleveland DW. Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E. Cell. 2010. PMC2921712

Holland AJ*, Fachinetti D*, Han JS, Cleveland DW. Inducible, reversible system for the rapid and complete degradation of proteins in mammalian cells. Proc Natl Acad Sci U S A. 2012. PMC3523849

Holland AJ, Fachinetti D, Zhu Q, Bauer M, Verma IM, Nigg EA, Cleveland DW. The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle. Genes Dev. 2012. PMC3533073

Moyer TC, Clutario KM, Lambrus BG, Daggubati V, Holland AJ. Binding of STIL to Plk4 activates kinase activity to promote centriole assembly. J Cell Biol. 2015. PMC4477857

Lambrus BG, Uetake Y, Clutario KM, Daggubati V, Snyder M, Sluder G, Holland AJ. p53 protects against genome instability following centriole duplication failure. J Cell Biol. 2015. PMC4494000

Academic Affiliations & Courses

Graduate Program Affiliation

Biochemistry, Cellular and Molecular Biology Graduate Program

Activities & Honors

Honors

  • Basil O'Connor Starter Research Award, March of Dimes, 2013

Memberships

  • American Association for Cancer Research, 2009
  • American Association for the Advancement of Science, 2013
  • American Society for Cell Biology, 2005
  • American Society for Cell Biology, 2012
    Membership Committee

Professional Activities

  • Associate Chair, Gordon Research Seminar on Cell Growth and Proliferation, 2011

Videos & Media

Lectures and Presentations

  • Inside the Cell
    PhD Course , Portugal (01/01/2011)
    Gulbenkian Science Institute

Recent News Articles and Media Coverage

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