Dr. Naik’s research focuses on the epidemiology of clinical complications of sickle cell trait, including chronic kidney disease and venous thromboembolism. Currently, very little is known about the clinical consequences of sickle cell trait. The goal of Dr. Naik's research is define the risk and modifying factors for disease related to sickle cell trait in order to inform genetic couseling, screening and treatment recommendations in individuals with trait.
Another main focus of Dr. Naik's research is the epidemiology and unique mechanisms of thrombosis in patients with hemoglobin disorders. Hypercoagulability in patients with hereditary hemoglobin disorders such as sickle cell disease results in severe complications such as venous thromboembolism and stroke. The primary aim of Dr. Naik’s research in this area is to characterize this thrombotic risk with the goal of identifying novel mechanisms of hypercoagulability and developing effective therapeutic strategies in patients with hemoglobinopathies.