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Tatiana Melnikova, M.D., Ph.D.

Photo of Dr. Tatiana Melnikova, M.D., Ph.D.

Assistant Professor of Pathology

Research Interests: Alzheimer's disease

Background

Dr. Tatiana Melnikova is an assistant professor of pathology at the Johns Hopkins University School of Medicine. Her research focuses on Alzheimer’s disease.

The main focus of her laboratory is the investigation of different animal models of Alzheimer''s disease and the contribution of different Aß species to the development of behavioral and cognitive deficits during disease progression.

She received her M.D. from State Medical Institute in Russia, and earned her Ph.D. from Russia’s Institute of Mental Health of the Russian Academy of Medical Science.

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Titles

  • Assistant Professor of Pathology

Departments / Divisions

Education

Degrees

  • M.D., State Medical Institute (Russia) (1981)
  • Ph.D., Institute of Mental Health of the Russian Academy of Medical Science (Russia) (1993)

Research & Publications

Research Summary

The main focus of Dr. Melnikova’s laboratory is the investigation of different animal models of Alzheimer's disease and the contribution of different Aß species to the development of behavioral and cognitive deficits during disease progression.

By using different experimental treatments or genetic manipulations to alter Aß production, they analyze the reversibility of the cognitive deficits at different stages of disease.

In other projects they are looking at the pathogenic mechanisms involved in autism spectrum disorder and investigating the pathways implicated in schizophrenia-like endophenotypes.

Selected Publications

Melnikova T, Fromholt S, Kim HS, Lee D, Xu G, Price A, Moore BD, Golde TE, Felsenstein KM, Savonenko AV and Borchelt DR. Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-amyloidosis. The Journal of Neuroscience. 2013; 33(9):3765-79. PMCID: PMC23447589

SavonenkoA*, Melnikova T*, Wang Y, Ravert H, Gao Y, Lee D, Cho E, Sayyida N, Hiatt A, Troncoso J, Dannals R, Pomper M, Horti A. Cannabinoid CB2 receptors in a mouse model of Aβ amyloidosis: immunohistochemical analysis and suitability as a PET biomarker of neuroinflammation. PLOS ONE, 2015; 10(6): e0129618

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