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Russell Kenneth Hales, M.D.

Photo of Dr. Russell Kenneth Hales, M.D.

Director, Thoracic Oncology Multidisciplinary Program

Assistant Professor of Radiation Oncology and Molecular Radiation Sciences


Expertise: Esophageal Cancer, Lung Cancer, Mesothelioma, Non-Small Cell Lung Cancer, Radiation Oncology, Small Cell Lung Cancer, Stereotactic Ablative Radiotherapy, Stereotactic Body Radiation Therapy, Stomach Cancer, Thymoma more

Research Interests: Novel radiation sensitizers in non small cell lung cancer; Characterization of organ motion in thoracic tumors more


Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
Appointment Phone: 410-502-8000

401 N. Broadway
Baltimore, MD 21231 map
Phone: 410-955-7390

Johns Hopkins Bayview Medical Center
Appointment Phone: 410-502-8000

4940 Eastern Avenue
Baltimore, MD 21224 map
Phone: 410-955-7390


Russell Hales, M.D., assistant professor of radiation oncology and molecular radiation sciences, focuses clinical and research efforts on thoracic malignancies in the Department of Radiation Oncology. As director of Thoracic Multidisciplinary Clinic, he helps to provide an expedited treatment recommendation and counseling for patients with newly diagnosed lung and esophagus cancer by all specialists in one office visit. He is involved in the development of the Lung Cancer Center of Excellence. more


  • Director, Thoracic Oncology Multidisciplinary Program
  • Assistant Professor of Radiation Oncology and Molecular Radiation Sciences
  • Assistant Professor of Oncology



  • MD, Johns Hopkins University School of Medicine (2005)


  • Johns Hopkins University School of Medicine / Radiation Oncology (2010)

Board Certifications

  • American Board of Radiology / Radiation Oncology (2011)

Research & Publications

Selected Publications

Dr. Hales research activities focus on improving the effectiveness of radiation therapy for patients with lung and esophagus cancer. His interests bridge pre-clinical models of cancer treatment with innovative therapies. By exploring the effects of hedgehog pathway signaling on tumor response to radiation treatment, Dr. Hales research group is translating pre-clinical discovery to clinical trials to improve outcomes in patients needing radiation treatment.

He also evaluates new radiation technologies and their use in patients with lung cancer. For example, 4D MRI is being investigated as a means of more accurately tracking tumor motion with breathing, which results in improved targeting of tumor. He is also analyzes the benefit of daily image guidance in patients undergoing radiation therapy. Predictive models are being created which help personalize need for image guidance in patients undergoing therapy.

Jing Zeng, Khaled Aziz, Blake Aftab, Michael Armour, Sivarajan T. Chettiar, Rajendra Gajula, Nishant Gandhi, Tarek Salih, Joseph Herman, John Wong, Charles M. Rudin, Phuoc T. Tran, Russell K. Hales. Hedgehog pathway inhibition radiosensitizes non-small cell lung cancers. Clinical Cancer Research, Under Review Jan 2012.

Teboh Roland, Russell Hales, Todd McNutt, John Wong, Patricio Simari, Erik Tryggestad. A method for deriving a 4D-interpolated balanced planning target for mobile tumors. Medical Physics 2012 Jan 39 (1): 195-205.

Jing Zeng, Alfred P. See, Khaled Aziz, Saravanan Thiyagarajan, Tarek Salih, Rajendra P. Gujula, Michael Armour, Jillian Phallen, Stephanie Terezakis, Lawrence Kleinberg, Kristen Redmond, Russell K. Hales, Roberto Salvatori, Alfredo Quinones-Hinojosa, Phuoc T. Tran, Michael Lim. Nelfinavir induces radiation sensitization in pituitary adenoma cells. Cancer Biol Ther 2011 Oct 1 (7): 657-73.

Phuoc T. Tran, Russell K. Hales, Jing Zeng, Khaled Aziz , Tarek Salih, Rajendra P. Gajula, Sivarajan Chettair, Rachit Kumar, Danny Song and Theodore L. DeWeese. Tissue Biomarkers for Prostate Cancer Radiation Therapy. Under Review 2011

Russell Hales, Moody Wharam. Pediatric High-Grade Glioma: Clinical, Treatment-Related, and
Biologic Prognostic Factors, Accepted for Publication, European Journal of Clinical & Medical
Oncology July 2011.
Husain H, Hann C, Hales R Radiotherapy in small-cell lung cancer. Oncology. 2010 Oct, 24 (11): 1047-1049.

Hales, R.K. Bachereau, J. Ribas, A. Tarhini, A.A. Weber, J.S. Fox, B.A. and Drake, C.G. Assessing Oncologic Benefit in Clinical Trials of Immunotherapy Agents. Annals of Oncology. 2010 Oct; 21 (10): 1944-1941.

Hales, R.K. Shokek, O. Burger, P.C. Paynter, N.P. Chaichana, K.L. Quiones-Hinojosa, A. Jallo, G.I., Cohen, K.J. Song, D.Y. Carson, B.S. and Wharam M.D. Prognostic Factors in Pediatric High-Grade Astrocytoma: The Importance of Accurate Pathologic Diagnosis. J Neurooncol. 2010 Aug; 99 (1): 65-71.

Holmes, K.W. Hales, R.K. Chu, S. Maxwell, M.J. Mogayzel, P.J. Zeitlin, P.L. Modulation of Sp1 and Sp3 in lung epithelial cells regulates ClC-2 chloride channel expression. American Journal of Respiratory Cell and Molecular Biology, 29: 499-505, 2003.

Videos & Media

Meet Russell Hales, M.D.

Russell Hales, M.D., Assistant Professor of Radiation Oncology and Molecular Sciences at the Johns Hopkins Kimmel Cancer Center's Lung Cancer Multidisciplinary Clinic discusses how all resources come together, in one room to, in one day, for patients benefit for the best lung cancer treatment.

The Johns Hopkins Kimmel Cancer Center's Lung Cancer Multidisciplinary Clinic

Learn about the Thoracic Oncology Multidisciplinary Clinic at the Johns Hopkins Kimmel Cancer Center. Our experts will discuss what to expect during your visit and offer treatment options and support.

Radiation Therapy for Lung Cancer

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