Research & Publications +
Dr. Hales research activities focus on improving the effectiveness of radiation therapy for patients with lung and esophagus cancer. His interests bridge pre-clinical models of cancer treatment with innovative therapies. By exploring the effects of hedgehog pathway signaling on tumor response to radiation treatment, Dr. Hales research group is translating pre-clinical discovery to clinical trials to improve outcomes in patients needing radiation treatment.
He also evaluates new radiation technologies and their use in patients with lung cancer. For example, 4D MRI is being investigated as a means of more accurately tracking tumor motion with breathing, which results in improved targeting of tumor. He is also analyzes the benefit of daily image guidance in patients undergoing radiation therapy. Predictive models are being created which help personalize need for image guidance in patients undergoing therapy.
Jing Zeng, Khaled Aziz, Blake Aftab, Michael Armour, Sivarajan T. Chettiar, Rajendra Gajula, Nishant Gandhi, Tarek Salih, Joseph Herman, John Wong, Charles M. Rudin, Phuoc T. Tran, Russell K. Hales. Hedgehog pathway inhibition radiosensitizes non-small cell lung cancers. Clinical Cancer Research, Under Review Jan 2012.
Teboh Roland, Russell Hales, Todd McNutt, John Wong, Patricio Simari, Erik Tryggestad. A method for deriving a 4D-interpolated balanced planning target for mobile tumors. Medical Physics 2012 Jan 39 (1): 195-205.
Jing Zeng, Alfred P. See, Khaled Aziz, Saravanan Thiyagarajan, Tarek Salih, Rajendra P. Gujula, Michael Armour, Jillian Phallen, Stephanie Terezakis, Lawrence Kleinberg, Kristen Redmond, Russell K. Hales, Roberto Salvatori, Alfredo Quinones-Hinojosa, Phuoc T. Tran, Michael Lim. Nelfinavir induces radiation sensitization in pituitary adenoma cells. Cancer Biol Ther 2011 Oct 1 (7): 657-73.
Phuoc T. Tran, Russell K. Hales, Jing Zeng, Khaled Aziz , Tarek Salih, Rajendra P. Gajula, Sivarajan Chettair, Rachit Kumar, Danny Song and Theodore L. DeWeese. Tissue Biomarkers for Prostate Cancer Radiation Therapy. Under Review 2011
Russell Hales, Moody Wharam. Pediatric High-Grade Glioma: Clinical, Treatment-Related, and
Biologic Prognostic Factors, Accepted for Publication, European Journal of Clinical & Medical
Oncology July 2011.
Husain H, Hann C, Hales R Radiotherapy in small-cell lung cancer. Oncology. 2010 Oct, 24 (11): 1047-1049.
Hales, R.K. Bachereau, J. Ribas, A. Tarhini, A.A. Weber, J.S. Fox, B.A. and Drake, C.G. Assessing Oncologic Benefit in Clinical Trials of Immunotherapy Agents. Annals of Oncology. 2010 Oct; 21 (10): 1944-1941.
Hales, R.K. Shokek, O. Burger, P.C. Paynter, N.P. Chaichana, K.L. Quiones-Hinojosa, A. Jallo, G.I., Cohen, K.J. Song, D.Y. Carson, B.S. and Wharam M.D. Prognostic Factors in Pediatric High-Grade Astrocytoma: The Importance of Accurate Pathologic Diagnosis. J Neurooncol. 2010 Aug; 99 (1): 65-71.
Holmes, K.W. Hales, R.K. Chu, S. Maxwell, M.J. Mogayzel, P.J. Zeitlin, P.L. Modulation of Sp1 and Sp3 in lung epithelial cells regulates ClC-2 chloride channel expression. American Journal of Respiratory Cell and Molecular Biology, 29: 499-505, 2003.