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Joseph L. Mankowski, D.V.M., Ph.D.

Joseph Leonard Mankowski, D.V.M., Ph.D.

Photo of Dr. Joseph L. Mankowski, D.V.M., Ph.D.

Professor of Molecular and Comparative Pathobiology

Research Interests: Neuropathology; Retrovirology

Contact for Research Inquiries

733 N. Broadway
MRB 827
Baltimore, MD 21205 map
Phone: 410-955-9770
Fax: 410-955-9823

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Background

Dr. Joseph L. Mankowski is a professor of molecular and comparative pathobiology, pathology and neurology at the Johns Hopkins University School of Medicine. His research focuses on the impact of HIV on the peripheral nervous system. His lab identified biomarkers that predict the onset of central nervous system disease arising from the simian immunodeficiency virus (SIV) and human immunodeficiency virus (HIV).

His team is studying the immunopathogenesis of HIV infection using the SIV/macaque model. They are using the SIV animal model to test the FDA-approved HIV drug maraviroc for its ability to reduce damage to the nerves and heart.

Dr. Mankowski received his undergraduate degree in neurobiology and behavior from Cornell University. He earned his D.V.M. from Cornell University and his Ph.D. in human genetics from the Johns Hopkins University. He completed a residency in pathology at Johns Hopkins and joined the Johns Hopkins faculty in 1992.

Dr. Mankowski provides diagnostic pathology support for the diverse animal species used in biomedical research at Johns Hopkins and is a diplomate of the American College of Veterinary Pathologists.

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Titles

  • Professor of Molecular and Comparative Pathobiology
  • Professor of Neurology
  • Professor of Pathology

Education

Degrees

  • B.S., Cornell University (New York) (1983)
  • D.V.M., Cornell University (New York) (1987)
  • Ph.D., Johns Hopkins University (Maryland) (1998)

Additional Training

  • Diplomate, Veterinary Anatomic Pathology, American College of Veterinary Pathologists (1998)
Johns Hopkins University, Baltimore, MD, 1996, Comparative Pathology; University of Pennsylvania, Kennett Square, PA, 1988, Large Animal Medicine and Surgery

Research & Publications

Research Summary

The Mankowski lab group studies the immunopathogenesis of HIV infection using the SIV/macaque model.

Pathogenesis of HIV-induced nervous system and cardiac disease processes
HIV is well known for its ability to induce loss of CD4+ T-cells leading to immune suppression manifest as AIDS. HIV infection also causes debilitating disease in the brain, the peripheral nervous system and in the heart secondary to infection of macrophages. Although virus-induced damage to these organs is common, the pathogenesis remains poorly defined. Using the SIV/macaque model of HIV, we use a multidisciplinary approach to dissect the mechanisms underlying these diseases, including the central role of macrophage activation.

Host genetics and lentiviral-induced CNS disease
The role that host genetics play in HIV-associated cognitive disorders is poorly understood. We have identified a novel association between expression of a MHC class I allele in pigtailed macaques and SIV-induced CNS disease that sets the stage for studies defining how MHC class I-mediated control of SIV replication in the brain influences SIV CNS disease outcomes.

Lab Website: Joseph Mankowski Lab

Selected Publications

Dorsey JL, Mangus LM, Oakley JD, Beck SE, Kelly KM, Queen SE, Metcalf Pate KA, Adams RJ, Marfurt CF, Mankowski JL. Loss of Corneal Sensory Nerve Fibers in SIV-infected Macaques: An Alternate Approach to Investigate HIV-induced PNS Damage. Am J Pathology, June 2014, 184(6):1652-9.

Tuxbury KA, Shaw GC, Montali RJ, Clayton LA, Kwiatkowski NP, Dykstra MJ, Mankowski JL. Fusarium solani species complex associated with carapace lesions and branchitis in captive American horseshoe crabs (Limulus polyphemus). Diseases of Aquatic Organisms, July 2014, 109(3):223-230.

Meulendyke KA, Queen SE, Engle EL, Shirk EN, Liu J, Steiner JP, Nath A, Tarwater PM, Graham DR, Mankowski JL, Zink MC. Combination Fluconazole/paroxetine Treatment Abrogates Neurodegeneration Despite Continued Neuroinflammation and Viral Replication in an SIV model of HIV Neurological Disease. J Neurovirology December 2014, 20(6):591-602.

Mangus LM, Dorsey JL, Laast VA, Hauer P, Queen SE, Adams RJ, McArthur JC, Mankowski JL. Neuroinflammation and Virus Replication in the Spinal Cord of SIV-infected Macaques. J Neuropathology and Exptl Neurology, Jan 2015, 74(1):38-47.

Feng N, Huke S, Zhu G, Tocchetti CG, Sa Shi, Aiba T, Kaludercic N, Hoover DB, Beck SE, Mankowski JL, Tomaselli GF, Bers DM, Kass DA, Paolocci N. Constitutive BDNF/TrkB signaling is required for normal cardiac contraction and relaxation. Proc Natl Acad Sci USA. 2015 Feb 10;112(6): 1880-5.

Beck SE, Kelly KM, Queen SE, Adams RJ, Tarwater PM, Mankowski JL. Macaque Species Susceptibility to SIV: Increased Incidence of SIV CNS Disease in Pigtailed Macaques Versus Rhesus Macaques. J Neurovirol. 2015 Apr;21(2):148-58.

Beck SE, Queen SE, Witwer KW, Metcalf Pate KA, Mangus LM, Gama L, Adams RJ, Clements JE, Zink MC, Mankowski JL. Paving the Path to HIV Neurotherapy: Predicting SIV CNS Disease. Eur J Pharmacol. 2015 July; (759)301-312.

Brew BJ, Robertson K, Wright EJ, Churchill M, Crowe S, Deeks S, Garcia-Martinez V, Gelman B, Johnson V, Margolis D, Mankowski JL, Rausch D, Spencer B. HIV Eradication Symposium: Will the Brain Be Left Behind? J Neurovirol. 2015 Jun;21(3):322-34.

Freeman Z, Rice K, Soto P, Metcalf Pate K, Weed M, Ator N, DeLeon I, Wong D, Zhou Y, Mankowski J, Zink MC, Adams RJ, Hutchinson E,. Neurocognitive Dysfunction and Pharmacologic Intervention Using Guanfacine in a Rhesus Macaque Model of Self-Injurious Behavior. Translational Psychiatry 2015; 19;5:e567.

Metcalf Pate KA, Lyons CE, Dorsey JL, Shirk EN, Queen SE, Adams RJ, Gama L, Morrell CN, Mankowski JL. Platelet activation and platelet-monocyte aggregate formation contribute to decreased platelet count during acute simian immunodeficiency virus infection in pig-tailed macaques. J Infect Dis. 2013 Sep;208(6):874-83. doi: 10.1093/infdis/jit278. Epub 2013 Jul 11.

Olson EK, Shaw GC, Hutchinson E, Schultz-Darken N, Bolton I, Parker JB, Morrison J, Baxter VK, Metcalf Pate KA, Mankowski JL, Carlson CS. Bone disease in the common marmoset: radiographic and histological findings. In press, Vet Path 2015; 52(5):883-93.

Dorsey JL, Mangus LM, Hauer P, Ebenezer G, Queen SE, Laast VA, Adams RJ, Mankowski JL. Persistent PNS Damage in SIV-infected Macaques Receiving Antiretroviral Therapy. Epub ahead of Print, J Neuropathology and Exptl Neurology, 2015. PMID 26426267

Kelly KM, Beck SE, Pate KA, Queen SE, Dorsey JL, Adams RJ, Avery LB, Hubbard W, Tarwater PM, Mankowski JL. "Neuroprotective maraviroc monotherapy in simian immunodeficiency virus-infected macaques: reduced replicating and latent SIV in the brain." AIDS. 2013 Oct 29. [Epub ahead of print]

Helke KL, Queen SE, Mankowski JL. 14-3-3 Protein in CSF Reflects SIV-Mediated Pre-Synaptic Damage. Curr HIV Res. 2013 Jun;11(4):281-7.

Ebenezer G, McArthur JC, Polydefkis M, Dorsey JL, O'Donnell R, Hauer P, Adams RJ, Mankowski JL. "SIV-induced impairment of neurovascular repair: A potential role for VEGF." J Neurovirol. 2012 Jun;18(3):222-30. doi: 10.1007/s13365-012-0102-5. Epub 2012 May 2.

Kelly KM, Tarwater PM, Karper JM, Bedja D, Queen SE, Tunin RS, Adams RJ, Kass DA, Mankowski JL. "Diastolic dysfunction is associated with myocardial viral load in SIV-infected Macaques." AIDS. 2012 April 24;26(7):815-23.

Metcalf Pate KA, Pohlmeyer CW, Walker-Sperling VW, Foote JB, Najarro KM, Cryer CG, Salgado M, Engle E Shirk EN, Queen SE, Chioma S, Vermillion MS, Bullock B, Li M, Lyons CE, Adams RJ, Gama L, Zink MC, Clements JE, Mankowski JL, Blankson JN. A murine viral outgrowth assay to detect residual HIV-1 in patients with undetectable viral loads. Epub ahead of print, JID 2015. PMID 25883388

Academic Affiliations & Courses

Graduate Program Affiliation

Pathobiology Graduate Program

Cellular and Molecular Medicine Graduate Program

Activities & Honors

Professional Activities

  • Diplomate, American College of Veterinary Pathologists
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