The Song lab studies mechanisms underlying mammalian neurogenesis, especially the cellular and molecular mechanisms that adult neural stem cells and their development in the mature central nervous system. The lab uses an integrated approach to study rodent and human neural stem cells in cell culture and in animal models utilizing technologies in molecular biology, cell biology, biochemistry, epigenetics, virology, histology, in vivo multiphoton confocal imaging, electrophysiology, mouse genetics and animal behaviors.
Current projects include characterizing properties of adult neural stem cells and neurogenesis; investigating intrinsic and extrinsic mechanisms regulating fate choice of adult neural stem cells and development of newborn neurons in the adult brain; characterizing contributions of newborn neurons at multiple levels in the adult brain, including single-cell electrophysiology in acute slices, local neuronal circuitry integration in vivo using optogenetic and multi-electrode recordings, and contribution to specific animal behaviors; exploring epigenetic mechanisms regulating adult neural plasticity.
The Song lab also is interested in understanding how defects in adult neurogenesis and epigenetic mechanisms contribute to mental disorders.
Lab Website: Hongjun Song Laboratory
Guo, J.U., Su, Y., Shin, J.H., Shin, J., Li, H., Xie, B., Zhong, C., Hu, S., Le, T., Fan, G., Zhu, H., Chang, Q., Gao, Y., Ming, G.L., Song, H. (2014). Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain. Nature Neuroscience 17, 215-22. [PMC in progress]
Song, J., Sun, J., Moss, J., Wen, Z., Sun, G.J., Hsu, D., Zhong, C., Davoudi, H., Christian, K.M., Toni, N., Ming, G.L., and Song, H. (2013). Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus. Nature Neuroscience 16, 1728-1730. [PMC in progress]
Jang, M., Bonaguidi, M.A., Kitabatake, Y., Sun, J., Song, J., Kang, E., Jun, H., Zhong, C., Su, Y., Guo, J.U., Wang, M.X., Sailor, K.A., Kim, J.Y., Gao, Y., Christian, K.M., Ming, G-l., and Song, H. (2013). Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesis. Cell Stem Cell 12, 215-23. [PMC3569732]
Song, J., Zhong, C., Bonaguidi, M.A., Sun, G.J., Hsu, D., Gu, Y., Meletis, K., Huang, Z.J., Ge, S., Enikolopov, G., Deisseroth, K., Luscher, B., Christian, K., Ming, G-l., and Song, H. (2012). Neuronal circuitry mechanism regulating adult quiescent neural stem cell fate decision. Nature 489:150-4. [PMC3438284]
The Huntington’s Disease iPSC Consortium. (2012). Induced pluripotent stem cells from patients with Huntington’s disease show CAG repeat expansion associated phenotypes. Cell Stem Cell 11, 264-78. [PMC3804072]