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Mark Lewis Lessne, MD

Assistant Professor of Radiology and Radiological Science
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Main Location

The Johns Hopkins Hospital

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Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

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  • Assistant Professor of Radiology and Radiological Science

Centers & Institutes

  • Interventional Radiology Center


Angioplasty, Arterial Occlusive Disease, Arteriovenous Fistulas, Chronic Total Occlusions, Claudication, Deep Venous Thrombosis, Diabetic Foot Ulcers, Diagnostic Radiology, Kidney Cancer, Liver Cancer, Lower Extremity Angioplasty, Lower Extremity Stenting, Peripheral Arterial Disease, Peripheral Vascular Disease, Radiofrequency Ablation for Lung, Liver, Kidney and Bone Lesions, Radiology, Renal Artery Disease, Renal Vascular Disease, Uterine Fibroids, Varicocele, Vascular and Interventional Radiology, Vascular Malformations, Venous Disease, Venous Occlusive Disease, Venous Thromboembolism, Visceral Angioplasty, Visceral Stenting

Research Interests

Peripheral arterial disease; Limb salvage; Interventional oncology; Endovascular, stent-assisted cerebral aneurysm coiling; Device innovation


Dr. Mark Lewis Lessne is an Assistant Professor in the Division of Vascular and Interventional Radiology within The Johns Hopkins Medicine Department of Radiology and Radiological Science.

Dr. Lessne specializes in peripheral arterial disease, with emphasis on endovascular therapy for limb salvage. His other clinical interests include minimally invasive treatment of venous disease, hepatic and renal malignancies, genitourinary diseases, and medical device innovation and design.

Dr. Lessne completed his undergraduate studies in mathematics, chemistry, and theatre arts at Boston University, and was granted early acceptance into Boston University’s Medical School, graduating cum laude with his medical doctorate. He received his diagnostic radiology residency training at Duke University Medical Center, serving as Chief Resident. He completed his subspecialty training in vascular and interventional radiology, with additional mini-fellowship training in neuroradiology, also at Duke.

Dr. Lessne is certified by the American Board of Radiology and is a member of the Society of Interventional Radiology, the Radiological Society of North America, the American College of Radiology, and the North American Society for Cardiovascular Imaging.


  • English


Society of Interventional Radiology

Radiological Society of North America

American College of Radiology

North American Society for Cardiovascular Imaging

Additional Resources +
  • Education +


    • Boston University School of Medicine ( Boston MA ) (2005)


    • Duke University School of Medicine/Diagnostic Radiology ( Durham NC ) (2010)


    • Duke University School of Medicine/Vascular and Interventional Radiology ( Durham NC ) (2011)


    • Diagnostic Radiology, American Board of Radiology (2010)
  • Research & Publications +

    Selected Publications

    Lessne ML, Shah NP, Stinchon JF, Cross, ME, Oates ME. “Optimized Scintigraphic Evaluation of the Hydronephrotic Horseshoe Kidney.” J Nucl Med Technol. 2007 Dec; 35(4):255.

    Lessne ML, Shah P, Alexander MJ, Barnhart HX, Powers C, Golshani K, Ferrell A, Enterline D, Zomorodi A, Smith T, Britz GW. “Thromboembolic Complications Associated with Neuroform™ Microdelivery Stent Assisted Treatment of Cerebral Aneurysms: The Duke Cerebrovascular Center Experience in 235 Patients with 274 Stents.” Neurosurgery. 2011 Aug; 69:369–375.

    Clinical Trials

    1. Site PI: Prospective, Randomized, Controlled Investigation Of Prostate Artery Embolization With Embosphere Microspheres Compared To Transurethral Resection Of The Prostate For The Treatment Of Symptomatic Benign Prostatic Hyperplasia, 2013-present.

    2. Co- Investigator: Philips Pivotal Clinical Trial Protocol for MRI-Guided High Intensity Focused Ultrasound Ablation of Uterine Fibroids, 2013-Present.

  • Academic Affiliations & Courses +
  • Activities & Honors +


    Faculty Teacher of the Year, Johns Hopkins Vascular and Interventional Radiology Fellowship, 2012-2013

    Resident Teacher of the Year, Duke University, Department of Radiology, 2009-2010

    Outstanding Radiology Teacher of the Year, Duke University Medical School, 2008-2009

    Lecturer of the Year, Duke University Physician Assistant Program, 2007-2008

    Chief Resident 2009-2010, Duke University, Department of Radiology

    Alpha Omega Alpha International Thespian Society Phi Beta Kappa Pi Mu Epsilon,

    Mathematics Honor Society United States Achievement Academy National Collegiate Medical Professions Award Nominee

    Golden Key Honor Society Boston University Honors Program Boston University Scholar

    Professional Activities

    Associate Fellowship Program Director, Johns Hopkins University, Division of Vascular and Interventional Radiology, 2013-present.

    Director, Physician Assistants, Johns Hopkins University, Division of Vascular and Interventional Radiology, 2012-present.

    Advisor, Center for Biomedical Innovation and Design. Johns Hopkins University, School of Engineering,, 2011-present.

    Advisor, Art as Applied to Medicine Graduate Program, Johns Hopkins University, 2011-present.

    Radiology Lecturer. Johns Hopkins University, Department of Radiology; Duke University School of Medicine; Duke University Physician Assistant Program, 2006-present.

    Advanced Physical Examination Instructor. University of Pittsburgh School of Medicine, 2005.

    MCAT Instructor (Classroom and Online, World-Wide), Curriculum Writer (National/International), Teacher Trainer. Kaplan, Inc, 1999-2003.

    Reader and Director, Recording for the Blind and Dyslexic. RFB&D, Inc., Cambridge, MA, 2001-2002.

  • Videos & Media +


    Vascular and Interventional Radiology

    Dr. Mark Lessne provides an overview of the practice of interventional radiology, including the diagnosis and treatment of peripheral artery disease (PAD).

    Lectures and Presentations

    Interventional Radiology Management of the Trauma Patient, Department of Surgery, Johns Hopkins University, Baltimore, MD, 2013.

    Infrapopliteal Arterial Interventions Workshop, Society of Interventional Radiology Annual Meeting, New Orleans, LA, 2013.

    Acute and Chronic DVT, Hematology Ground Rounds, Johns Hopkins University, Baltimore, MD, 2013.

    Acute Limb Ischemia, e-Radiology, online 2013.

    Featured Abstract Series Podcast, Interviewer, Journal of Vascular and Interventional Radiology, online 2013.

    Infrapopliteal Arterial Interventions Workshop, Society of Interventional Radiology Annual Meeting, San Francisco, CA, 2013.

    Interventional Radiology Management of Deep Venous Thrombosis, Johns Hopkins DVT Symposium, Baltimore, MD, 2012.

    Diabetic Vascular Care, Endocrinology Grand Rounds, Johns Hopkins University, Baltimore, MD, 2012.

    Critical Limb Ischemia, Internal Medicine Grand Rounds, Johns Hopkins University, Baltimore, MD, 2012.

  • Upcoming Events +
  • Contact & Locations +


    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Phone: 410-614-5183
    Appointment Phone: 410-614-2227
    Location Map


    • Radiology and Radiological Science

    For Research Inquiries Contact


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