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Karthik S Suresh, M.D.
Instructor of Medicine
Languages: English, Tamil
Expertise: General Internal Medicine
Research Interests: ROS signaling; endothelial cell biology; vascular biology; calcium singaling
Dr. Karthik Suresh is an instructor of medicine at the Johns Hopkins University School of Medicine. His areas of clinical interest and expertise include general internal medicine, pulmonology and critical.
He earned his B.S. and M.D. from the University of Louisville School of Medicine. He completed his residency at the Osler Medicine training program at Johns Hopkins, and performed a fellowship in Pulmonary / Critical Care Medicine at Johns Hopkins.
- Instructor of Medicine
- MD, University of Louisville School of Medicine (2008)
- Johns Hopkins University School of Medicine / Internal Medicine (2011)
- Johns Hopkins University School of Medicine / Pulmonary Medicine (2012)
- Johns Hopkins University School of Medicine (2016)
- American Board of Internal Medicine / Internal Medicine (2011)
Research & Publications
Our lab focuses on the mechanisms of microvascular endothelial dysfunction across two lung diseases with high morbidity and mortality: Acute Lung Injury (ALI) and Pulmonary Arterial Hypertension (PAH). Using endothelial cells (ECs) isolated from humans, mice and rats, as well as animal models of ALI and PAH, we investigate the role of elevated reactive oxygen species (ROS) and intracellular calcium in regulating disease-specific abnormalities in EC function. In ALI, we study signaling pathways governing formation of paracellular gaps between endothelial cells, which clinically leads to alveolar flooding and hypoxemia. For PAH, we study the effect of ROS and calcium signaling on EC migration and proliferation as it relates to formation of vaso-occlusive lesions in the distal arterioles of the lung, a known contributor to elevations in pulmonary artery pressures in this disease.
Huetsch J, Suresh K, Bernier M, Shimoda LA. Update on Novel Targets and Potential Treatment Avenues in Pulmonary Hypertension. Am J Physiol Lung Cell Mol Physiol 2016 [Epub ahead of print]
Suresh K, Servinsky LE, Reyes J, Baksh S, Undem C, Caterina MJ, Pearse DB, Shimoda LA. Hydrogen Peroxide-induced Calcium Influx in lung microvascular endothelial cells involves TRPV4. Am J Physiol Lung Cell Mol Physiol. 309: L1467–L1477, 2015
Suresh K, Belchis D, Askin F, Pearse DB, Terry, P. "Occupational asthma due to aerosolized lipophilic coating materials", Lung 194(5): 787-9, 2016.
Suresh K, Shimoda LA. Lung Circulation, Compr Physiol 6:897‐943, 2016
Suresh K, Thomas SV, Suresh G. Design, data analysis and sampling techniques for clinical research. Annals of Indian Academy of Neurology. 2011;14(4):287-290.