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Robert G. Hamilton, M.S., Ph.D.

Photo of Dr. Robert G. Hamilton, M.S., Ph.D.

Director, Dermatology, Allergy and Clinical Immunology (DACI) Reference Laboratory

Professor of Medicine

Research Interests: Medical product and environmental allergen testing; Diagnostic allergy testing; Natural rubber latex allergy; Humoral (antibody) immune responses in allergic and infectious disease; Immunogenicity and allergenicity of new drugs ...read more

Background

Robert G. Hamilton, Ph.D., D.ABMLI is currently Professor of Medicine and Pathology at The Johns Hopkins University School of Medicine in Baltimore, Maryland. He joined the Division of Allergy and Clinical Immunology of the Department of Medicine in 1981 and is the Director of the Dermatology-Allergy Clinical Immunology (DACI) Reference Laboratory. He is a fellow of the American Academy and College of Allergy, Asthma and Immunology. He has served as co-editor the past 2 editions of the Manual of Molecular and Clinical Laboratory Immunology. He has authored more than 300 peer-reviewed publications, reviews and book chapters. He lectures on a variety of topics, including laboratory diagnosis and management of human allergic disease and assessment of immunogenicity and allergenicity of new drugs.

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Titles

  • Director, Dermatology, Allergy and Clinical Immunology (DACI) Reference Laboratory
  • Senior Laboratory Investigator
  • Professor of Medicine
  • Professor of Pathology

Centers & Institutes

Education

Degrees

  • B.S., University of Michigan (Ann Arbor) (Michigan) (1972)
  • M.S., University of Michigan (Ann Arbor) (Michigan) (1973)
  • Ph.D., Johns Hopkins University (Maryland) (1980)

Additional Training

  • American Board of Nuclear Medicine Science
  • American Board of Medical Laboratory Immunology
Brookhaven National Laboratory, Long Island, NY, 1974, Reactor, linear accelerator & medical physics; Dr. Rosalyn Yalow, Nobel Laureate, New York,, NY, 1981, Postdoctoral Fellowship

Research & Publications

Research Summary

Current research interests focuses on:

  1. the role of IgE and IgG antibodies in modulating human allergic disease, 
  2. the utility of these antibody measurements in the diagnosis and management of human allergic disease, and 
  3. the immunogenicity of new and FDA-approved drugs, biologicals and vaccines.

In 1967, IgE antibody was identified as the ‘gate-keeper’ of allergic reactions. By binding onto mast cells and basophils, it controls the release of mediators following allergen exposures that induce allergic symptoms. Our work focuses on the accurate quantification of allergen-specific IgE, IgG and IgA antibodies in an attempt to identify indicators of risk for and protection from allergic reactions. Together with my colleague N. Franklin Adkinson Jr., M.D., we are investigating the safety of new and approved drugs for their ability to elicit IgE and IgG antibody responses as part of clinical trials leading to FDA approval. Finally, I oversee the Johns Hopkins Dermatology, Allergy and Clinical Immunology (DACI) Reference Laboratory which is a full service diagnostic allergy laboratory that provides IgE and IgG antibody measurements as well as measurements of indoor aeroallergens to aid in the diagnosis and management of human allergic disease.

Lab

Johns Hopkins Dermatology, Allergy and Clinical Immunology Reference Laboratory

Academic Affiliations & Courses

Graduate Program Affiliation

Biomedical Engineering Program

Activities & Honors

Honors

  • Mallinckrodt Scholarship Award, American Society of Nuclear Medicine, 1979
  • Berson-Yalow Award, American Society of Nuclear Medicine, 1980
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