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Kazuyo Yamaji-Kegan, Ph.D.

Photo of Dr. Kazuyo Yamaji-Kegan, Ph.D.

Assistant Professor of Anesthesiology and Critical Care Medicine

Research Interests: Pulmonary hypertension; Cardiopulmonary diseases

Background

Dr. Kazuyo Kegan is an Assistant Professor of Anesthesiology and Critical Care Medicine at the Johns Hopkins University School of Medicine. She earned her undergraduate and Ph.D. degrees from Kagoshima University in Japan and completed her postdoctoral research training at Johns Hopkins University. 

The goal of Dr. Kegan’s research program is to understand the mechanisms, regulation, and functional outcomes of immune responses in the pulmonary vasculature during the development of pulmonary hypertension.  She has strong expertise in vascular biology and has focused on the role of inflammatory mediators in pulmonary angiogenesis, vasculogenesis, and remodeling, particularly under hypoxic conditions.

She is a member of the American Heart Association, the American Thoracic Society and the Pulmonary Hypertension Association. She has been recognized with the Young Investigator Award, and the 2011 - 2013 Pfizer Research Fellowships in Pulmonary Arterial Hypertension, the 2016-2017 PHA Proof of Concept Research Grant from the Pulmonary Hypertension Association of the American Thoracic Society.

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Titles

  • Assistant Professor of Anesthesiology and Critical Care Medicine

Education

Degrees

  • B.A., Kagoshima University (Japan) (1995)
  • Ph.D., Kagoshima University (Japan) (2005)

Research & Publications

Research Summary

The goal of Dr. Kegan’s research program is to understand the mechanisms, regulation, and functional outcomes of immune responses in the pulmonary vasculature during the development of pulmonary hypertension.  She has strong expertise in vascular biology and has focused on the role of inflammatory mediators in pulmonary angiogenesis, vasculogenesis, and remodeling, particularly under hypoxic conditions.

Dr. Kegan is currently working to determine the mechanisms by which vascular injury and the subsequent immune response by macrophages contribute to disease progression in pulmonary hypertension using in vivo pathophysiology, in vitro cellular and molecular biology, and genetic and biochemical approaches. Clinical samples from patients with pulmonary hypertension also are utilized to uncover the relevant signaling pathways that might reveal new therapeutic targets. She is principal investigator of a research program with the ultimate goal of identifying new therapeutic targets to treat pulmonary hypertension.

Technology Expertise Keywords

Vascular Biology

Selected Publications

Johns RA, Takimoto E, Meuchel LW, Elsaigh E, Zhang A, Heller NM, Semenza GL, Yamaji-Kegan K*. Hypoxia-inducible factor 1a is a critical downstream mediator for hypoxia-induced mitogenic factor (FIZZ1/RELMa)-induced pulmonary hypertension. Arterio Thromb Vasc Biol. 36(1):134-144, 2016. PMID: 26586659. *Corresponding author.

Yamaji-Kegan K*, Takimoto E, Zhang A, Weiner NC, Meuchel LW, Berger AE, Cheadle C, Johns RA. Hypoxia-induced mitogenic factor (FIZZ1/RELMa) induces endothelial cell apoptosis and subsequent interleukin-4-dependent pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 306(12):L1090-L1103, 2014. PMID: 24793164. *Corresponding author.

Yamaji-Kegan K, Su Q, Angelini DJ, Myers AC, Cheadle C, Johns RA. Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMa) increases lung inflammation and activates pulmonary microvascular endothelial cells via an IL-4–dependent mechanism. J Immunol 185(9):5539-5548, 2010. PMID: 20889544

Yamaji-Kegan K, Su Q, Angelini DJ, Johns RA. IL-4 is proangiogenic in the lung under hypoxic conditions. J Immunol 182(9):5469-5476, 2009. PMID: 19380795

Yamaji-Kegan K, Su Q, Angelini DJ, Champion HC, Johns RA. Hypoxia-induced mitogenic factor has proangiogenic and proinflammatory effects in the lung via VEGF and VEGF receptor-2. Am J Physiol Lung Cell Mol Physiol 291(6): L1159-L1168, 2006. PMID: 16891392

Activities & Honors

Memberships

  • American Heart Association
  • American Thoracic Society
  • Pulmonary Hypertension Association
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