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Mehdi Pirooznia, M.D., Ph.D.

Assistant Professor of Psychiatry and Behavioral Sciences

See Research on Pubmed | See Research on Google Scholar



  • Assistant Professor of Psychiatry and Behavioral Sciences

Centers & Institutes

  • Mood Disorders Center

Research Interests

Genomics, High-throughput Sequencing, Psychiatric Genetics, Mood Disorders


  • English


  • The American Society of Human Genetics (ASHG)
  • The International Society for Computational Biology (ISCB)
  • The International Society of Psychiatric Genetics (ISPG) 

Additional Resources

Additional Resources +
  • Education +


    • M.D., Beheshti University of Medical University, Tehran, Iran, 2001
    • MSc, Exeter Univeristy, Exeter, UK, 2004, Bioinformatics and Computational Biology
    • Ph.D., University of Southern Mississippi, Hattiesburg, MS, 2007, Bioinformatics and Computational Biology


    • Johns Hopkins University School of Medicine, Baltimore, MD, 2010, Postdoctoral Fellow
    • Johns Hopkins University School of Medicine, Baltimore, MD, 2011, Alexander Wilson Schweizer Fellow in Mood Disorders and Genetics
  • Research & Publications +

    Research Summary

    My research focus is on analysis and biological interpretation of high-throughput sequencing data and other high-dimensional biological datasets. Specifically, I am interested in the genetics of mood disorders such as bipolar disorders and major depression.

    Selected Publications View all on PubMed

    1. SEQC/MAQC-III Consortium. A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium. Nat Biotechnol. 2014 Aug 24. doi: 10.1038/nbt.2957. PubMed PMID: 25150838.
    2. Pirooznia M, Kramer M, Parla J, Goes F, Potash JB, McCombie WR, Zandi PP. Validation and assessment of variant calling pipelines for next-generation sequencing. Hum Genomics. 2014 Jul 30;8(1):14. PubMed PMID: 25078893.
    3. Pirooznia M, Seifuddin F, Judy J, Goes FS, Potash JB, Zandi PP. Metamoodics: meta-analysis and bioinformatics resource for mood disorders. Mol Psychiatry. 2014 Jul;19(7):748-9. doi: 10.1038/mp.2013.118. Epub 2013 Sep 10. PubMed PMID: 24018898; PubMed Central PMCID: PMC3955217.
    4. Pirooznia M, Seifuddin F, Goes FS, Leek JT, Zandi PP. SVAw - a web-based application tool for automated surrogate variable analysis of gene expression studies. Source Code Biol Med. 2013 Mar 11;8(1):8. doi: 10.1186/1751-0473-8-8. PubMed PMID: 23497726; PubMed Central PMCID: PMC3614430.
    5. Chen YC, Carter H, Parla J, Kramer M, Goes FS, Pirooznia M, Zandi PP, McCombie WR, Potash JB, Karchin R. A hybrid likelihood model for sequence-based disease association studies. PLoS Genet. 2013;9(1):e1003224. doi: 10.1371/journal.pgen.1003224. Epub 2013 Jan 24. PubMed PMID: 23358228; PubMed Central PMCID: PMC3554549.
    6. Goes FS, Hamshere ML, Seifuddin F, Pirooznia M, Belmonte-Mahon P, Breuer R, Schulze T, Nöthen M, Cichon S, Rietschel M, Holmans P, Zandi PP; Bipolar Genome Study (BiGS), Craddock N, Potash JB. Genome-wide association of mood-incongruent psychotic bipolar disorder. Transl Psychiatry. 2012 Oct 23;2:e180. doi: 10.1038/tp.2012.106. PubMed PMID: 23092984; PubMed Central PMCID: PMC3565814.
    7. Zhang K, Pirooznia M, Arabnia HR, Yang JY, Wang L, Luo Z, Deng Y. Genomic signatures and gene networking: challenges and promises. BMC Genomics. 2011 Dec 23;12 Suppl 5:I1. doi: 10.1186/1471-2164-12-S5-I1. Epub 2011 Dec 23. PubMed PMID: 22369358; PubMed Central PMCID: PMC3287490.
    8. Pirooznia M, Wang T, Avramopoulos D, Valle D, Thomas G, Huganir RL, Goes FS, Potash JB, Zandi PP. SynaptomeDB: an ontology-based knowledgebase for synaptic genes. Bioinformatics. 2012 Mar 15;28(6):897-9. doi: 10.1093/bioinformatics/bts040. Epub 2012 Jan 27. PubMed PMID: 22285564; PubMed Central PMCID: PMC3307115.
    9. Pirooznia M, Seifuddin F, Judy J, Mahon PB; Bipolar Genome Study (BiGS) Consortium, Potash JB, Zandi PP. Data mining approaches for genome-wide association of mood disorders. Psychiatr Genet. 2012 Apr;22(2):55-61. doi: 10.1097/YPG.0b013e32834dc40d. PubMed PMID: 22081063; PubMed Central PMCID: PMC3306768.
    10. Belmonte Mahon P, Pirooznia M, Goes FS, et al; Bipolar Genome Study (BiGS) Consortium, The Wellcome Trust Case Control Consortium Bipolar Disorder Group, Potash JB, Zandi PP. Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2011 Apr;156B(3):370-8. doi: 10.1002/ajmg.b.31172. Epub 2011 Feb 8. PubMed PMID: 21305692; PubMed Central PMCID: PMC3178836.


  • Academic Affiliations & Courses +
  • Activities & Honors +
  • Videos & Media +
  • Events +
  • Contact & Locations +


    • Psychiatry and Behavioral Sciences

    For Research Inquiries Contact

    Meyer 4-119D
    The Johns Hopkins Hospital
    600 North Wolfe St.
    Baltimore, MD 21287-5371

    Phone: 410-955-2572
    Fax: 410-502-0065


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