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Mehdi Pirooznia, M.D., M.S., Ph.D.

Photo of Dr. Mehdi Pirooznia, M.D., M.S., Ph.D.

Assistant Professor of Psychiatry and Behavioral Sciences

Research Interests: Genomics, High-throughput Sequencing, Psychiatric Genetics, Mood Disorders

Contact for Research Inquiries

The Johns Hopkins Hospital
Meyer Building
600 N. Wolfe Street
Baltimore, MD 21287 map
Phone: 410-955-2572
Fax: 410-502-0065

Email me



  • Assistant Professor of Psychiatry and Behavioral Sciences

Departments / Divisions

Centers & Institutes



  • M.D., Shahid Beheshti University of Medical Sciences (Iran) (1996)
  • M.S., University of Exeter Medical School (United Kingdom) (2004)
  • Ph.D., University of Southern Mississippi (Mississippi) (2007)

Additional Training


  • Johns Hopkins University School of Medicine, Baltimore, MD, 2010, Postdoctoral Fellow

  • Johns Hopkins University School of Medicine, Baltimore, MD, 2011, Alexander Wilson Schweizer Fellow in Mood Disorders and Genetics

Research & Publications

Research Summary

My research focus is on analysis and biological interpretation of high-throughput sequencing data and other high-dimensional biological datasets. Specifically, I am interested in the genetics of mood disorders such as bipolar disorders and major depression.

Selected Publications

View all on Pubmed

Pirooznia M, Wang T, Avramopoulos D, Potash JB, Zandi PP, Goes FS. High-throughput sequencing of the synaptome in major depressive disorder. Mol Psychiatry. 2015 Jul 28. doi: 10.1038/mp.2015.98. PubMed PMID: 26216301

Goes FS, McGrath J, Avramopoulos D, Wolyniec P, Pirooznia M, et. al. Genome-wide association study of schizophrenia in Ashkenazi Jews. Am J Med Genet B Neuropsychiatr Genet. 2015 Jul 21. doi: 10.1002/ajmg.b.32349. PubMed PMID: 26198764

Lee RS, Pirooznia M, Guintivano J, Ly M, Ewald ER, Tamashiro KL, Gould TD, Moran TH, Potash JB. Search for common targets of lithium and valproic acid identifies novel epigenetic effects of lithium on the rat leptin receptor gene. Transl Psychiatry. 2015 Jul 14;5:e600. doi: 10.1038/tp.2015.90. PubMed PMID: 26171981

Pirooznia M, Goes FS, Zandi PP. Whole-genome CNV analysis: advances in computational approaches. Front Genet. 2015 Apr 13;6:138. doi: 10.3389/fgene.2015.00138. eCollection 2015. Review. PubMed PMID: 25918519; PubMed Central PMCID: PMC4394692

SEQC/MAQC-III Consortium. A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium. Nat Biotechnol. 2014 Aug 24. doi: 10.1038/nbt.2957. PubMed PMID: 25150838.

Pirooznia M, Kramer M, Parla J, Goes F, Potash JB, McCombie WR, Zandi PP. Validation and assessment of variant calling pipelines for next-generation sequencing. Hum Genomics. 2014 Jul 30;8(1):14. PubMed PMID: 25078893.

Pirooznia M, Seifuddin F, Judy J, Goes FS, Potash JB, Zandi PP. Metamoodics: meta-analysis and bioinformatics resource for mood disorders. Mol Psychiatry. 2014 Jul;19(7):748-9. doi: 10.1038/mp.2013.118. Epub 2013 Sep 10. PubMed PMID: 24018898; PubMed Central PMCID: PMC3955217.

Pirooznia M, Seifuddin F, Goes FS, Leek JT, Zandi PP. SVAw - a web-based application tool for automated surrogate variable analysis of gene expression studies. Source Code Biol Med. 2013 Mar 11;8(1):8. doi: 10.1186/1751-0473-8-8. PubMed PMID: 23497726; PubMed Central PMCID: PMC3614430.

Chen YC, Carter H, Parla J, Kramer M, Goes FS, Pirooznia M, Zandi PP, McCombie WR, Potash JB, Karchin R. A hybrid likelihood model for sequence-based disease association studies. PLoS Genet. 2013;9(1):e1003224. doi: 10.1371/journal.pgen.1003224. Epub 2013 Jan 24. PubMed PMID: 23358228; PubMed Central PMCID: PMC3554549.

Goes FS, Hamshere ML, Seifuddin F, Pirooznia M, Belmonte-Mahon P, Breuer R, Schulze T, Nöthen M, Cichon S, Rietschel M, Holmans P, Zandi PP; Bipolar Genome Study (BiGS), Craddock N, Potash JB. Genome-wide association of mood-incongruent psychotic bipolar disorder. Transl Psychiatry. 2012 Oct 23;2:e180. doi: 10.1038/tp.2012.106. PubMed PMID: 23092984; PubMed Central PMCID: PMC3565814.

Zhang K, Pirooznia M, Arabnia HR, Yang JY, Wang L, Luo Z, Deng Y. Genomic signatures and gene networking: challenges and promises. BMC Genomics. 2011 Dec 23;12 Suppl 5:I1. doi: 10.1186/1471-2164-12-S5-I1. Epub 2011 Dec 23. PubMed PMID: 22369358; PubMed Central PMCID: PMC3287490.

Pirooznia M, Wang T, Avramopoulos D, Valle D, Thomas G, Huganir RL, Goes FS, Potash JB, Zandi PP. SynaptomeDB: an ontology-based knowledgebase for synaptic genes. Bioinformatics. 2012 Mar 15;28(6):897-9. doi: 10.1093/bioinformatics/bts040. Epub 2012 Jan 27. PubMed PMID: 22285564; PubMed Central PMCID: PMC3307115.

Pirooznia M, Seifuddin F, Judy J, Mahon PB; Bipolar Genome Study (BiGS) Consortium, Potash JB, Zandi PP. Data mining approaches for genome-wide association of mood disorders. Psychiatr Genet. 2012 Apr;22(2):55-61. doi: 10.1097/YPG.0b013e32834dc40d. PubMed PMID: 22081063; PubMed Central PMCID: PMC3306768.

Belmonte Mahon P, Pirooznia M, Goes FS, et al; Bipolar Genome Study (BiGS) Consortium, The Wellcome Trust Case Control Consortium Bipolar Disorder Group, Potash JB, Zandi PP. Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2011 Apr;156B(3):370-8. doi: 10.1002/ajmg.b.31172. Epub 2011 Feb 8. PubMed PMID: 21305692; PubMed Central PMCID: PMC3178836.

Activities & Honors


  • The American Society of Human Genetics (ASHG)
  • The International Society for Computational Biology (ISCB)
  • The International Society of Psychiatric Genetics (ISPG) 
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