Angiogenic and anti-angiogenic growth factors; Angioblasts or vascular precursors; Oxygen radicals; Vaso-occlusion mechanisms that cause nonperfusion of the retinal and choroidal vasculatures in diabetic and sickle cell retinopathy
Gerard Lutty, Ph.D., is the G. Edward and G. Britton Durell Professor of Ophthalmology and the director of the Ocular Vasculogenesis and Angiogenesis Laboratory at the Wilmer Eye Institute, which studies the development of blood vessels in the eye and how they change in diseases like age-related macular degeneration, retinopathy of prematurity, and sickle cell and diabetic retinopathies. The focus is on the factors that stimulate new blood vessels, angiogenic factors, and naturally occurring inhibitors of angiogenesis, antiangiogenic factors, with the goal of developing therapies to stop the blood vessels from being blocked in ischemic retinopathies and inhibit the growth of neovascularization in the retina and choroid.
Dr. Lutty received his M.S. in microbiology at Catholic University and his Ph.D. in cell biology/biocehmistry at the Johns Hopkins University School of Medicine. He first joined the Wilmer faculty in 1979.