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R. Bradley Sack, M.D., Sc.D.

Photo of Dr. R. Bradley Sack, M.D., Sc.D.

Joint Appointment in Medicine

Research Interests: Diarrhea; Cholera; Enterotoxigenic E. coli; India; Bangladesh; Epidemiology; Ecology

Background

Dr. R. Bradley Sack holds a joint appointment in the Department of Medicine at the Johns Hopkins University School of Medicine. He is also a professor emeritus of international health and epidemiology in the Johns Hopkins Bloomberg School of Public Health

His research focuses on microbiology, with a particular emphasis on infectious diarrheal diseases. His lab discovered enterotoxigenic E. coli, which is known as the most frequent bacterial cause of diarrhea in small children living in the developing world. 

Dr. Sack received his undergraduate degree from Lewis and Clark College. He earned his M.D. and M.S. degrees from the University of Oregon School of Medicine. He completed his residency in internal medicine at the University of Washington, Seattle, and a fellowship in infectious diseases at the Johns Hopkins School of Public Health. He then received a Sc.D. degree from Johns Hopkins. Dr. Sack joined the Johns Hopkins faculty in 1962.

Dr. Sack is the founding director of the Johns Hopkins University International Travel Clinic. He was the head of the Division of Laboratory Sciences and the Division of Community Health at the International Center for Diarrheal Disease Research in Bangladesh from 1991 to 1994. From 1977 to 1985, he was the chief of the Division of Geographic Medicine at the Johns Hopkins School of Medicine, and the resident coordinator of the Johns Hopkins Center for Medical Research and Training in Calcutta, India, from 1968 to 1970.

His work has been recognized numerous awards, including the Johns Hopkins University Alumni Association Global Achievement Award (2015), the Donald McKay Award (2011), the Samuel P. Asper Award for Achievement for Advancing International Medical Education, Johns Hopkins Medical and Surgical Association (2007) and the Johns Hopkins School of Medicine Distinguished Medical Alumnus Award (2007).

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Titles

  • Joint Appointment in Medicine

Departments / Divisions

Research & Publications

Research Summary

Dr. Sack’s research focuses on cholera and other diarrheal diseases. He began work on cholera in Calcutta in 1952 and has continued that work to the present. Studies included microbiology, treatment, epidemiology and ecology. In 1968 his lab discovered enterotoxigenic E. coli, which is known as the most frequent bacterial cause of diarrhea in small children living in the developing world. Also during 1968, he helped in the discovery, development, and subsequent teaching of oral rehydration therapy for the treatment of secretory diseases. Since the 1970s, he has conducted studies of the epidemiology and ecology of cholera in rural Bangladesh.

Selected Publications

Sack, DA, Sack RB, Chaignat CL. "Getting serious about cholera." New Engl J Med. 2006 Aug 17;355(7):640-51

Huq A, Sack RB, Nizam A, Longini IM, Nair GB, Ali A, Morris JG Jr, Khan MN, Siddique AK, Yunus M, Albert MJ, Sack DA, Colwell RR. "Critical factors influencing the occurrence of Vibrio cholerae in the environment of Bangladesh." Appl Environ Microbiol. 2005 Aug;71(8):4645-54

Sack RB. Prophylactic antimicrobials for traveler's diarrhea: an early history. Clin Infect Dis. 2005 Dec 1;41 Suppl 8:S553-6

Qadri F, Ahmed T, Ahmed F, Sack RB, Sack DA, Svennerhollm, AM, PTE study group, Safety and immunogencitiy of an oral, inactivated enterotoxigenic Eschierichi coli plus cholera toxin B subunit vaccine in Bangladesh children, 18-36 months of age." Vaccine. 2003;21:3994-2403

Activities & Honors

Honors

  • Johns Hopkins University Alumni Association Global Achievement Award, 2015
  • Donald Mackay Award (with David Sack), 2011
  • Samuel P. Asper Award for Achievement for Advancing International Medical Education, Johns Hopkins Medical and Surgical Association, 2007
  • Johns Hopkins School of Medicine Distinguished Medical Alumnus Award, 2007
  • Peruvian National Academy of Medicine, 2003
  • Alumni member, Delta Omega Public Health Honorary Society, Alpha Chapter. Phi Beta Kappa, Lewis and Clark College, 1990
  • Distinguished Alumni Award, Lewis and Clark College, 1987

Memberships

  • American Society for Clinical Investigation, 1979
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