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Jinyuan Zhou, Ph.D.

Photo of Dr. Jinyuan Zhou, Ph.D.

Associate Professor of Radiology and Radiological Science

Research Interests: Development of new magnetic resonance imaging (MRI) techniques; Development and clinical applications of chemical exchange saturation transfer (CEST) MRI; Development, optimization, and contrast mechanism of amide proton transfer (APT) MRI; Brain tumor imaging; Stroke pH imaging. ...read more

Background

Dr. Jinyung Zhou is an Associate Professor in the Johns Hopkins Medicine Department of Radiology and Radiological Science. Dr. Zhou''s research focuses on developing new methodologies of in vivo magnetic resonance imaging (MRI) and MRS to study brain function and physiology.

Dr. Zhou received his undergraduate degree in physics from the Chinese Academy of Sciences’ National Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics. He earned his Ph.D. in physics from the Johns Hopkins University School of Medicine. He performed a fellowship focused on in vivo MRI at the Johns Hopkins University School of Medicine. Dr. Zhou joined the Johns Hopkins faculty in 2001.

Dr. Zhou has been recognized by Johns Hopkins University with the Award for Scientific Excellence in the Division of MR Research in 2003. He is a member of American Association for Cancer Research (AACR) and the International Society for Cerebral Blood Flow and Metabolism.

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Titles

  • Associate Professor of Radiology and Radiological Science

Departments / Divisions

Education

Degrees

  • Ph.D., Wuhan University (China) (1996)

Additional Training

In Vivo MRI, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, 1999, Fellowship

Research & Publications

Research Summary

Dr. Zhou's research focuses on developing new methodologies of in vivo magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) to study brain function and disease. His most recent work includes absolute quantification of cerebral blood flow, quantification of functional MRI, magnetization transfer mechanism, development of chemical exchange saturation transfer (CEST) technology, brain pH MR imaging, tissue protein MR imaging, and high-resolution diffusion tensor imaging (DTI). A major part of his current research is in vivo imaging of experimental brain tumor models and clinical imaging of brain tumor patients using a new MRI technique, the amide proton transfer (APT) imaging.

Selected Publications

View all on Pubmed

1. Jinyuan Zhou, Jean-Francois Payen, David A. Wilson, Richard J. Traystman, and P. C. M. van Zijl. Using the Amide Proton Signals of Intracellular Proteins and Peptides to Detect pH Effects in MRI. Nat. Med. 9, 1085-1090 (2003).

2. Jinyuan Zhou, Jaishri O. Blakeley, Jun Hua, Mina Kim, John Laterra, Martin G. Pomper, and Peter C. M. van Zijl. A Practical Data Acquisition Method for Human Brain Amide Proton Transfer (APT) Imaging. Magn. Reson. Med. 60, 842-849 (2008). PMC2579754.

3. Jinyuan Zhou, Erik Tryggestad, Zhibo Wen, Bachchu Lal, Tingting Zhou, Rachel Grossman, Kun Yan, Silun Wang, De-Xue Fu, Jaishri Blakeley, Eric Ford, Betty Tyler, John Laterra, and Peter C.M. van Zijl. Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides. Nature Med. 17, 130-134 (2011). PMC3058561.

4. Jinyuan Zhou, He Zhu, Michael Lim, Lindsay Blair, Alfredo Quinones-Hinojosa, Steven A. Messina, Charles Eberhart, Martin Pomper, John Laterra, Peter B. Barker, Peter C.M. van Zijl, and Jaishri Blakeley. Three-Dimensional Amide Proton Transfer MR Imaging of Gliomas: Initial Experience and Comparison with Gadolinium Enhancement. J. Magn. Reson. Imaging. 38, 1119-1128 (2013). PMC3664658.

5. Xiaohua Hong, Li Liu, Meiyun Wang, Kai Ding, Ying Fan, Bo Ma, Bachchu Lal, Betty Tyler, Antonella Mangraviti, Silun Wang, John Wong, John Laterra, Jinyuan Zhou. Quantitative Multi-parametric MRI Assessment of Glioma Response to Radiotherapy in a Rat Model. Neuro-Oncology. 16, 856-867 (2014). PMC4022217.

Activities & Honors

Honors

  • Award for Scientific Excellence, Johns Hopkins University, 2003
  • Second-Class Natural Science Prize, the Chinese Academy of Sciences, 1997
  • Outstanding Presidential Scholarship, the Chinese Academy of Sciences, 1996
  • First-Class Hong Kong Yilida Scholarship, the Chinese Academy of Sciences, 1996
  • Second-Class Young Scientist Award, Tianjuan Wang Foundation, 1994
  • First-Class Graduate Scholarship, Wuhan Institute of Physics, 1996
  • Second-Class Graduate Scholarship, Wuhan Institute of Physics, 1995

Memberships

  • American Association for Cancer Research (AACR), 2006
  • International Society for Cerebral Blood Flow and Metabolism, 2002
  • International Society of Magnetic Resonance in Medicine (ISMRM), 1998
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