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Anirudha Singh, Ph.D.

Photo of Dr. Anirudha Singh, Ph.D.

Assistant Professor of Urology

Research Interests: Polymer Chemistry, Stem Cells, Biomaterials, Regenerative Urology, Tissue Engineering, and Design & Fabrication

Contact for Research Inquiries

Translational Tissue Engineering Center, Wilmer Eye Institute
400 N. Broadway
Robert H. & Clarice Smith Building, Suite 5001R
Baltimore, MD 21231 map

Background

Dr. Singh received his Bachelors of Engineering (B.E) in Polymer Engineering from Birla Institute of Technology, Ranchi, India (2001), his Masters of Technology (M.Tech) from Indian Institute of Technology, New Delhi, India (2003) and his Ph. D in Polymer Science from the University of Akron, Ohio, USA (2008). He was a Maryland Stem Cell Research Foundation postdoctoral fellow (MSCRF, 2010-12) and an Arthritis Foundation (AF, 2012-14) postdoctoral fellow at the Translational Tissue Engineering Center, Department of Biomedical Engineering, Johns Hopkins University. Before, his postdoctoral research fellowships, he worked in General Electric (GE), now SABIC-IP, as a product developer (2008-09). Dr. Singh joined the Department of Urology, Brady Urological Institute, at the Johns Hopkins School of Medicine as an instructor in 2014 and as a full time Assistant Professor since July 1st, 2015 with a secondary appointment in the Dept. of Chemical and Biomolecular Engineering, Johns Hopkins University.

Dr. Singh’s research interest is in finding clinically relevant simple solutions to complex health problems through translational scientific and engineering approaches. One of the main goals of his research group is “Regenerative Urology”, where the research is focused on design, fabrication and development of mechanically and biologically functional urinary tissues and organs, such as urinary diversion conduit, ureter and bladder. His group applies major themes including, biomaterials, polymer chemistry, stem cell and tissue engineering for regenerating tissues/organs, specifically urological tissues and organs, musculoskeletal and ocular tissues. His group also studies a variety of biomaterials-based deployment strategies that provide spatiotemporal delivery of biologics, including peptides, cells, nanomaterials, polymers and small molecules to augment endogenous repair responses and target degenerative diseases.

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Titles

  • Assistant Professor of Urology

Departments / Divisions

Education

Degrees

  • B.Eng., Birla Institute of Technology and Science (India) (2001)
  • M.Tech., Indian Institute of Technology (India) (2003)
  • Ph.D., University of Akron (Ohio) (2008)

Research & Publications

Research Summary

Dr. Singh’s research interest is in finding clinically relevant simple solutions to complex health problems through translational scientific and engineering approaches. One of the main goals of his research group is “Regenerative Urology”, where the research is focused on design, fabrication and development of functional urinary tissues and organs, such as urinary diversion conduit, ureter and bladder. His group applies major themes including, biomaterials, polymer chemistry, stem cell and tissue engineering for regenerating biologically and mechanically functional tissues/organs, specifically urological tissues and organs, musculoskeletal and ocular tissues. His group also studies a variety of biomaterials-based deployment strategies that provide spatiotemporal delivery of biologics, including peptides, cells, nanomaterials, polymers and small molecules to augment endogenous repair responses and target degenerative diseases. 

Technology Expertise Keywords

Polymer Science & Engineering, Chemistry, Stem Cells Differentiation, Biomaterials, Tissue Engineering, Regenerative Medicine, Urology, Design & Fabrication

Selected Publications

Singh A, Corvelli M, Unterman S, Elisseeff J. Enhanced lubrication on tissue and biomaterial surfaces through peptide-mediated binding of hyaluronic acid. Nature Materials, 2014, 13:988-995.

Singh A, Li P, Elisseeff J. Surface-bound hyaluronic acid enhances water retention in contact lenses. Contact Lens & Anterior Eyes, 2014, 38:79-84.

Corvelli M, Singh A, Elisseeff J. Biodynamic performance of hyaluronic acid versus synovial fluid of the knee as a therapy for osteoarthritis. Methods, 2015, Epub ahead of print.

Singh A, Zhan J, Elisseeff J. Multifunctional modular poly(ethylene glycol) hydrogels for stem cell differentiation. Advance Functional Materials, 2013, 5:575-582.

Singh A, Deans L, Elisseeff J. Photomodulation of gene expression in hydrogels. ACS MacroLetters,2013, 2(3):269-272.

Beck J*, Singh A*, Rothensberg A, Elisseeff J. The independent roles of mechanical, structural and adhesion characteristics of 3D hydrogels on the regulation of cancer invasion and dissemination. Biomaterials, 2013, 34(37):9486-9495.

Singh A, Zhan J, Elisseeff J. Modulating chemistry of PEG hydrogels: effect of molecular composition and concentration on tissue development. Journal of Tissue Engineering & Regenerative Medicine, 2014.

Deans L*, Singh A*, Elisseeff J. Regulating gene-networks in 3D biomaterials. Proceedings of the National Academia of Sciences, U.S.A,2012, 109(38):15217-15277.

Zhan J*, Singh A*, Elisseeff J. Multifunctional aliphatic polyester for tissue engineering applications. Biomatter, 2012, 2(4):202-12.

Reid B, Gibson M, Singh A, Taube J, Furlong C, Murcia M, Elisseeff J. PEG hydrogel degradation and the role of the surrounding tissue environment. Journal of Tissue Engineering & Regenerative Medicine, 2015.

Singh A, Elisseeff J. Biomaterials for stem cell differentiation. Journal of Materials Chemistry,2012, 20:8832-47.

Pugh C, Singh A.Synthesis of Hyperbranched Polyacrylates by a Chloroinimer Approach. Macromolecules, 2010, 43:5222-32.

Pugh C, Raveendra B, Singh A, Reichel S, Garcia G. Design and Regioselective Synthesis of (2-Bromo-2-alkoxycarbonyl)ethyl Acrylates as Inimers for Hyperbranched (Co)Polyacrylates. Synth. Lett., 2010, 13:1947-50.

Chaicharoen K, Polce JM, Singh A, Pugh C, Wesdemiotis C. Characterization of linear and branched polyacrylates by tandem mass spectrometry. Analytical & Bioanalytical Chemistry, 2008, 392:595-607.

Patents

Synthesis of inimers and hyperbranched polymers based on 2-halo-3-hydroxypropionic acid, 2-halo-3-hydroxybutyric acid and their derivatives
Patent # WO 2008/045299 B2 | 04/17/2008

Transparent thermoplastic compositions having high flow and ductility and articles prepared there from
Patent # US8084134 | 12/27/2011

Academic Affiliations & Courses

Graduate Program Affiliation

Department of Chemical & Biomolecular Engineering, and Department of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University

Activities & Honors

Memberships

  • Biomedical Engineering Society (BMES)
  • Tissue Engineering and Regenerative Medicine (TERMIS)
  • Society For Biomaterials
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