Dr. Pomerantz and members of his lab currently study signaling pathways that are important in innate immunity, adaptive immunity, and in cancer, paying particular attention to pathways that regulate the activity of the pleiotropic transcription factor NF-kappaB. One molecule that signals to NF-kappaB is CARD11 and the team is investigating the biochemical mechanisms by which CARD11 transduces signals from the T-cell receptor to NF-kappaB. Using a new expression cloning strategy designed to isolate molecules that signal to NF-kappaB in lymphocytes, the team has cloned several novel signaling molecules that activate the NF-kappaB or NFAT transcription factors and is currently working to better understand their mechanisms of action.
Dr. Pomerantz and his team are also interested in the design of artificial cellular signaling circuits, which would provide new tools for controlling gene expression to be used in biological research and to engineer cell fate decisions in novel therapeutic approaches.
Lab Website: Joel Pomerantz Laboratory
Chan W, Schaffer TB, Pomerantz JL. "A quantitative signaling screen identifies CARD11 mutations in the CARD and LATCH domains that induce Bcl10 ubiquitination and human lymphoma cell survival." Mol Cell Biol. 2013 Jan;33(2):429-43. doi: 10.1128/MCB.00850-12. Epub 2012 Nov 12.
Szeto GL, Pomerantz JL, Graham DR, Clements JE. "Minocycline suppresses activation of nuclear factor of activated T cells 1 (NFAT1) in human CD4+ T cells." J Biol Chem. 2011 Apr 1;286(13):11275-82. doi: 10.1074/jbc.M110.210518. Epub 2011 Jan 31.
Lamason RL, Kupfer A, Pomerantz JL. "The dynamic distribution of CARD11 at the immunological synapse is regulated by the inhibitory kinesin GAKIN." Mol Cell. 2010 Dec 10;40(5):798-809. doi: 10.1016/j.molcel.2010.11.007.
Lamason RL, McCully RR, Lew SM, Pomerantz JL. "Oncogenic CARD11 mutations induce hyperactive signaling by disrupting autoinhibition by the PKC-responsive inhibitory domain." Biochemistry. 2010 Sep 28;49(38):8240-50. doi: 10.1021/bi101052d.
Lamason RL, Lew SM, Pomerantz JL. "Transcriptional target-based expression cloning of immunoregulatory molecules." Immunol Res. 2010 Jul;47(1-3):172-8. doi: 10.1007/s12026-009-8148-z. Review.