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M. Diane E. Griffin, M.D., Ph.D.

Photo of Dr. M. Diane E. Griffin, M.D., Ph.D.

Alfred and Jill Sommer Professor and Chair, Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health

Joint Appointment in Medicine

Research Interests: Measles; Viral encephalitis vaccines; Arboviruses; Alphaviruses; Sindbis virus vaccines; Immune response

Background

Dr. M. Diane E. Griffin is a professor of infectious diseases and of neurology at the Johns Hopkins University School of Medicine. Her research focuses on viral diseases. Dr. Griffin is the Alfred and Jill Sommer Professor and Chair in the Department of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health.

Her team is currently investigating how measles virus infection suppresses the immune system.

Dr. Griffin received her M.D. and Ph.D. from Stanford University.

She was the founding director of the Johns Hopkins Malaria Research Institute and past president of the American Society for Virology, the Association of Medical School Microbiology Chairs and the American Society for Microbiology. She currently serves as vice president of the National Academies of Science.

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Titles

  • Alfred and Jill Sommer Professor and Chair, Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health
  • Joint Appointment in Medicine
  • Joint Appointment in Neurology

Research & Publications

Research Summary

Dr. Griffin and her team study alphaviruses and acute encephalitis; and measles virus, immune response and vaccines.

Selected Publications

Schultz KL, Vernon PS, Griffin DE. "Differentiation of neurons restricts Arbovirus replication and increases expression of the alpha isoform of IRF-7." J Virol. 2015 Jan;89(1):48-60. doi: 10.1128/JVI.02394-14. Epub 2014 Oct 15.

Kulcsar KA, Baxter VK, Greene IP, Griffin DE. "Interleukin 10 modulation of pathogenic Th17 cells during fatal alphavirus encephalomyelitis." Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16053-8. doi: 10.1073/pnas.1418966111. Epub 2014 Oct 31.

Lin WH, Pan CH, Adams RJ, Laube BL, Griffin DE. "Vaccine-induced measles virus-specific T cells do not prevent infection or disease but facilitate subsequent clearance of viral RNA." MBio. 2014 Apr 15;5(2):e01047. doi: 10.1128/mBio.01047-14.

Metcalf TU, Baxter VK, Nilaratanakul V, Griffin DE. "Recruitment and retention of B cells in the central nervous system in response to alphavirus encephalomyelitis." J Virol. 2013 Mar;87(5):2420-9. doi: 10.1128/JVI.01769-12. Epub 2012 Dec 19.

Lin WH, Kouyos RD, Adams RJ, Grenfell BT, Griffin DE. "Prolonged persistence of measles virus RNA is characteristic of primary infection dynamics." Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14989-94. doi: 10.1073/pnas.1211138109. Epub 2012 Aug 7.

Activities & Honors

Honors

  • Maryland Women's Hall of Fame
  • Pioneer Award, International Society for Neurovirology
  • Rudolf Virchow Medal, University of Wurzburg
  • Wallace Sterling Lifetime Alumni Achievement Award, Stanford University
  • Gilman Scholar, Johns Hopkins University

Memberships

  • American Academy of Microbiology
  • National Academy of Sciences
  • Institute of Medicine
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