Skip Navigation
Find a Doctor


Photo of Dr. Brian O'Rourke

Brian O'Rourke, Ph.D.

Director, Multiphoton Laser Scanning Microscope Facility
Professor of Medicine



  • Director, Multiphoton Laser Scanning Microscope Facility
  • Professor
  • Director, Bernard Laboratory of Fundamental Research in Preventive Cardiology
  • Professor of Medicine

Centers & Institutes


Contact for Research Inquiries

Johns Hopkins University School of Medicine

720 Rutland Avenue
Ross 1060
Baltimore, MD 21205 map
Phone: 410-614-0034
Fax: 410-502-5055

Research Interests

Two-photon fluorescence imaging; Molecular manipulation of cardiac excitability; Ca-activated chloride currents; Oscillatory behavior of energy metabolism; Cardioprotection; Excitation-Contraction coupling in heart failure; Regulation of ion channels by energy metabolism in heart cells


Dr. Brian O’Rourke is a Professor of Medicine at the Heart and Vascular Institute. He studies the regulation of ion channels by energy metabolism in heart cells, oscillatory behavior of energy metabolism, excitation-contraction coupling in heart failure, ca-activated chloride currents and molecular manipulation of cardiac excitability.

Dr. O’Rourke holds a bachelor’s degree from Pennsylvania State University and a graduate degree from Thomas Jefferson University. He completed the Foerderer Fellowship and NIH training grant fellowships at the Thomas Jefferson University and a fellowship within the Cardiology Division at Johns Hopkins University before joining the Johns Hopkins faculty in 1993. He is a member of the International Society for Heart Research, the American Association for the Advancement of Science, the Sigma Xi Research Society, the Biophysical Society, the Cardiac Muscle Society, the Fellow of the American Heart Association , and the International Society for Heart Research, and serves on the editorial board of the Journal of Molecular and Cellular Biology and Basic Research in Cardiology. more

    Additional Information

  • Education +
    • B.S., Pennsylvania State University (Pennsylvania) (1983)
    • Ph.D., Thomas Jefferson University College of Graduate Studies - Philadelphia (Pennsylvania) (1990)

    Additional Training

    Thomas Jefferson University, Foerderer Fellowship; Thomas Jefferson University, NIH training grant; Johns Hopkins University, Cardiology Division
  • Research & Publications +

    Research Summary

    Regulation of ion channels by energy metabolism and reactive oxygen species in heart cells
    Oscillatory behavior of energy metabolism
    Molecular mechanisms of heart failure and Sudden Cardiac Death
    Mitochondrial ion channels and their role in protection against ischemic injury
    Two-photon and confocal fluorescence imaging

    Lab Website: O'Rourke Lab

    CORE Facilities

    Mass Spectometry and Proteomics Core

  • Academic Affiliations & Courses +

    Graduate Program Affiliation

    Cellular and Molecular Medicine Biomedical Engineering  
  • Activities & Honors +
  • Videos & Media +
Is This You? Edit Profile

© The Johns Hopkins University, The Johns Hopkins Hospital, and Johns Hopkins Health System. All rights reserved.