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Mehboob Ali Hussain, M.D.
Director, Cell Biology Core of Diabetes Research Center
Professor of Pediatrics
Languages: English, French, German, Hindi, Italian, Urdu
Expertise: General Pediatrics
Research Interests: Diabetes mellitus; Pancreatic beta-cell biology; Pancreatic beta cell regeneration; Pancreatic insulin secretion models
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The Johns Hopkins Hospital
Appointment Phone: 410-614-2359
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Dr. Mehboob Ali Hussain is an associate professor of pediatrics, medicine, and biological chemistry at the Johns Hopkins University School of Medicine. His research focuses on metabolism, with a particular focus on pancreatic beta cell regeneration and pancreatic insulin secretion models.
Dr. Hussain serves as the director of the Cell Biology Core of Diabetes Research Center at the Johns Hopkins School of Medicine.
His team is currently engaged in research that examines pancreatic beta cell biology and its relevance for the treatment of diabetes mellitus. When there is not enough insulin and more insulin is needed (as in obesity or in juvenile diabetes mellitus), the insulin-producing beta cells in the pancreas ramp up their function and also increase in number by cell division. How these two processes are regulated is poorly understood. The laboratory uses genetic mouse models and state-of-the-art molecular biological techniques to understand these two processes and identify potential drug targets for treating humans with either Type 1 (juvenile) and Type 2 diabetes mellitus
Dr. Hussain earned his M.D. from the University of Zurich Medical School in Switzerland. He completed clinical and research training at the University Hospital in Zurich and completed a residency in medicine at the New York University School of Medicine. Dr. Hussain was a research fellow in molecular endocrinology at Massachusetts General Hospital and Harvard Medical School. Dr. Hussain joined the Johns Hopkins faculty in 2005.
- Director, Cell Biology Core of Diabetes Research Center
- Director, Diabetes Research Center
- Professor of Pediatrics
- Professor of Biological Chemistry
- Professor of Medicine
Departments / Divisions
- MD, University of Zurich Medical School (1989)
- University Hospital Zurich / Internal Medicine (1995)
- New York University School of Medicine / Internal Medicine (2002)
- University Hospital Zurich / Endocrinology (1993)
- Medstar Union Memorial Hospital / Endocrinology Diabetes & Metabolism (2014)
- American Board of Internal Medicine / Endocrinology/Diabetes/Metabolism (2014)
- American Board of Internal Medicine / Internal Medicine (2002)
Research & Publications
Dr. Hussain’s research interest is in the area of diabetes mellitus and pancreatic beta-cell biology. The laboratory effort is directed towards better understanding of the pancreatic beta cell biology and its relevance for the treatment of diabetes mellitus. Their work focuses on the differentiation and regeneration of pancreatic endocrine cells from progenitor/stem cells. In vitro cell culture and in vivo animal models are used to elucidate the molecular mechanisms differentiation of stem cells. These techniques are also being used to identify the extra- and intracellular signals and transcription factors that regulate differentiation pathways of stem cells. A second line of investigation addresses the role of intracellular signals in the function and proliferation of insulin-producing pancreatic beta cells.
Lab Website: Mehboob Hussain Laboratory
W-Jin Song, Seshadri, M, Ashraf U, Mdluli T, Mondal P, Rao P, Keil M, Azevedo M, Rizzo M, Stratakis CA, Kirschner L, Hussain MA. "Snapin phosphorylation mediates incretin action and augments glucose-dependent insulin secretion from pancreatic ß-cells." Cell Metabolism, 2011 Mar 2;13:308-318.
Fulzele K, Riddle RC, DiGirolamo DJ, Cao X, Wan C, Chen D, Faugere MC, Aja S, Hussain MA, Brüning JC, Clemens TL. "Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition." Cell. 2010 Jul 23;142(2):309-19.
He L, Sabet A, Djedjos S, Miller R, Sun X, Hussain MA, Radovick S, Wondisford FE. "Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein." Cell. 2009 May 15;137(4):635-46.
W-Jin Song, W. Schreiber, F. Liu B. D. Kaufmann, E. Zhong, Wondisford. Hussain, M. A. "Exendin-4 stimulation of cyclin A2 in beta-cell proliferation." Diabetes. 2008 Sep;57(9):2371-81.
Hussain MA, Porras DL, Rowe MH, West JR, Wondisford FE. "Increased pancreatic betacell proliferation mediated by CREB binding protein gene activation." Mol. Cell. Biol. 2006 Oct;26(20):7747-59.
Activities & Honors
- Abstract review committee, IEE/SOM Medical Education Conference, Johns Hopkins, 2014
- Consultant, RenovoRx, 2010