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Rafael Enrique Guerrero-Preston, Dr.P.H., M.P.H.
Assistant Professor of Otolaryngology - Head and Neck Surgery
Research Interests: Discover and validate molecular markers of HPV disease; Translational epigenomics; Developing biomonitors for cancer early detection, clinical management and therapeutic development; Discover and validate molecular markers and biomonitors for cancer health disparities research ...read more
Dr. Guerrero-Preston is an Assistant Professor in Otolaryngology-Head and Neck Cancer and in Oncology, working with David Sidransky in the mechanistic understanding of key biological processes that link tumor suppressor gene silencing and oncogene activation in cancer, to develop new approaches for early detection in biofluids. Dr. Guerrero-Preston is an expert in the study of molecular changes that drive cancer initiation and progression, focusing on identifying novel genetic and epigenetic changes in smoking and pathogen-associated tumors.
Dr. Guerrero-Preston, was born and raised in Puerto Rico. He has hosted over thirty culturally diverse students in his laboratory, some of which are now medical students, biomedical doctoral students, post-doctoral researchers and Assistant Professors. Dr. Guerrero-Preston received a Doctor in Public Health degree from the University of Puerto Rico and completed a Cancer Prevention fellowship at Columbia University Mailman School of Public Health before coming to study cancer epigenetics with Dr. Sidransky at Hopkins.
Dr. Guerrero-Preston has pioneered the use of genome-wide DNA methylation arrays and sequencing technologies to discover, develop and validate unbiased genomic and epigenomic biomarkers for early detection research in cancer. Dr. Guerrero-Preston's research interests and expertise include: genetic and epigenetic alterations in cancer; unraveling the role of these alterations across the cancer spectrum, from pre-malignant lesions to advanced tumors; and expanding the study of these molecular changes to other chronic diseases, such as asthma, COPD, Parkinson's disease and Alzheimer.
He has published numerous peer-reviewed journal articles, has presented his work at national and international meetings and is the main co-inventor in eleven patents (2 granted). A natural collaborator, he is active in efforts to promote dialogue between scholars across the social and natural sciences, researchers, policy makers and community advocates about the contours of inequality in the contemporary United States, and its implications for medicine and public health.
- Assistant Professor of Otolaryngology - Head and Neck Surgery
- Assistant Professor of Oncology
Departments / Divisions
- B.A., Columbia College (New York) (1979)
- M.P.H., University of Puerto Rico School of Public Health (Puerto Rico) (1995)
- DrPH, University of Puerto Rico School of Public Health (Puerto Rico) (2004)
Videos & Media
Rafael Guerrero's Cancer Research Lab at Johns Hopkins University: Part 2 -- Identity
Rafael Guerrero's Cancer Research Lab at Johns Hopkins University: Part 3 -- HPV project
Recent News Articles and Media Coverage