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Anne Quy Hoa Le Thi, H.D.R., M.D., M.S.

Quy Hoa Le Thi, H.D.R., M.D., M.S.

Photo of Dr. Anne Quy Hoa Le Thi, H.D.R., M.D., M.S.

Assistant Professor of Pathology

Research Interests: Cancer metabolism

Contact for Research Inquiries

Johns Hopkins University School of Medicine
1550 Orleans Street
Cancer Research Building-2, Suite 303
Baltimore, MD 21231 map

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Background

Dr. Anne Le obtained her science knowledge from the Paris Descartes University, Cochin Port-Royal School of Medicine, in France where she acquired her Habilitation, the highest academic qualification a scholar can achieve in Europe. After her clinical training at Henri Poincaré University Hospital, Nancy, in France, Dr. Le started her post-doctoral research fellowship at the Johns Hopkins University School of Medicine in 2007. She was promoted to Instructor in 2010 then to Assistant Professor in 2011 and has been managing her own laboratory since 2011. Dr. Le’s work has yielded a number of contributions to the field of cancer metabolism, demonstrated by her publication record as a pioneer in this field. Dr. Le has successfully obtained funding from several sources, including National Institutes of Health (NIH) and other foundations, which not only reflects the innovation and significance of her ideas, but also her scientific independence as a Principal Investigator.

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Titles

  • Assistant Professor of Pathology
  • Assistant Professor of Oncology

Education

Degrees

  • M.D., Ho Chi Minh City University of Medicine and Pharmacy (Vietnam) (2000)
  • M.S., University Rene Descartes (Paris V) - U.E.R. Cochin-Port Royal - Paris - (France) (2004)
  • H.D.R., University Rene Descartes (Paris V) - U.E.R. Cochin-Port Royal - Paris - (France) (2015)

Research & Publications

Research Summary

Dr. Anne Le’ research primarily focuses on cancer metabolism. Using metabolomics technologies, her work has led to breakthrough discoveries revealing several characteristic features of the metabolism of cancer.  One of these, the dependence of cancer cells on glutamine metabolism, has translated into clinical trials as a novel therapy for cancer patients. Furthermore, her lab tracked the metabolic pathways in the remaining tumor cells after this novel therapy and identified the best-suited drugs for combined synergistic therapy. The depth of Dr. Le's expertise in cancer metabolism, in collaboration with other experts at Johns Hopkins, will lead to improved outcomes for cancer therapy.

Lab

You can find out more about Dr. Anne Le's laboratory here.

Dr. Anne Le's laboratory also runs a Metabolomics core as part of Institute for Clinical and Translational Research (ICTR) supported labs.

Provide consultation to basic, clinical, and translational research teams regarding the feasibility, design, power and costs of projects using metabolomics technologies;

Customize metabolic approaches based on specific research projects/questions: ranging from simple assays to high-throughput approaches such as global metabolic profiling on a wide variety of sample types;

Provide extensive data analysis and suggest options for subsequent steps towards clinical implementation.

 

Technology Expertise Keywords

Cancer metabolism- Metabolomics technologies

Selected Publications

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer. Proc Natl Acad Sci U S A. 2016 Aug 24. PMID: 27559084. Selected Publication in which Dr. Le is Corresponding author.

Glucose-independent Glutamine-driven TCA Cycle in Cancer Cells. Glutamine in Health and Disease. Glutamine in Clinical Nutrition, Nutrition and Health, DOI 10.1007/978-1-4939-1932-1_6. Selected Publication in which Dr. Le is Corresponding author.

Tumorigenicity of hypoxic respiring cancer cells revealed by a hypoxia–cell cycle dual reporter. Proc Natl Acad Sci U S A. 2014 Aug 26; 111(34): 12486–12491. PMID: 25114222. Selected Publication in which Dr. Le is Corresponding author.

Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell Metab. 2012 Jan 4;15(1):110-21. PMID: 22225880. Selected Publication in which Dr. Le is Corresponding author.

Academic Affiliations & Courses

Graduate Program Affiliation

Graduate Program in Pathobiology

Courses and Syllabi

  • Pathobiology of Cancer Course, Graduate Program in Pathobiology
    Classroom Instruction
    2013
  • The Translational Intersession Course on Metabolism for 3rd and 4th year Medical Students
    Classroom Instruction
    2015
  • Pathology and Disease Mechanisms Course, Graduate Program in Pathobiology
    Seminars
    2013

Videos & Media

Recent News Articles and Media Coverage

Johns Hopkins Scientists Track Metabolic Pathways to Find Drug Combinations for Pancreatic Cancer, Johns Hopkins Medicine News

Nanoparticle/Diabetes Drug Combo Kills Mouse Pancreatic Cancer Cells, ALN® Magazine

Cancer cells feed on sugar-free diet, ScienceDaily

Students’ global health projects honored at Rice 360° competition, Rice OEDK

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