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Daniel M. Raben, Ph.D.

Photo of Dr. Daniel M. Raben, Ph.D.

Professor of Biological Chemistry

Research Interests: Physiological functions of DGKs in neurons; Enzyme structure/function studies; Interfacial enzymology of lipid metabolizing signaling enzymes ...read more

Background

Dr. Daniel Raben is a member of the American Chemical Society, the American Society for Biochemistry and Molecular Biology (ASBMB), and The Biochemical Society. He is Editor-in-Chief of the Journal of Bioenergetics and Biomembranes, is the founder and past director of the Lipid Research Division of the ASBMB, and serves as the Meetings Chair for this society.  He has authored or co-authored over 70 peer-reviewed publications, and has received numerous awards, including an NIH grant on which he currently serves as primary investigator. 

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Titles

  • Professor of Biological Chemistry
  • Professor of Oncology
  • Professor of Physiology

Education

Degrees

  • B.S., University of Michigan (Michigan) (1976)
  • Ph.D., University of California (Irvine) (California) (1986)

Additional Training

University of California-Irvine, Irvine, CA, 1986, Biochemistry

Research & Publications

Research Summary

Dr. Raben is interested in the chemistry and biochemistry of lipids and lipid enzymes involved in signaling cascades. His laboratory’s major effort is studying the molecular aspects involved in regulating lipid metabolizing signaling enzymes and the physiological roles of this regulation. The control of these enzymes involves the modulation of two key parameters, their sub-cellular distribution and intrinsic enzymatic activity. The importance of this work is underscored by the fact that defects in lipid cascades often contribute to conditions such as diabetes, cardiovascular disease, neurological disorders, immune dysfunctions, and cancer.

Lab Website: Daniel Raben Laboratory

Selected Publications

Petro, E., and Raben, D.M. "Bacterial expression strategies for several Sus scrofa diacylglycerol kinase alpha constructs: solubility challenges." Scientific Reports. 2013;3:160.

Ueda S., Tu-Sekine, B. Yamanoue, M., Raben, D.M., and Shirai, Y. "The expression of diacylglycerol kinase theta during the organogenesis of mouse embryos." BMC Developmental Biology. 2013. 13:35.

Bolduc, D., Rahdar, M., Tu-Sekine, B., Sivakumaren, S.C., Raben, D., Amzel, L.M., Devreotes, P, Gabelli, S.B., and Cole, P. "Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis." Elife 2013 Jul 9;2:e00691.

Tu-Sekine, B., Goldschmidt, H., Petro, E, and Raben, D.M. "Diacylglycerol Kinase Theta: Regulation and Stability." Adv. Biol. Reg. 2013. Jan;53(1):118-26.

Tu-Sekine B, and Raben, D.M. "Dual Regulation of DGK-θ: Polybasic Proteins Promote Activation by Phospholipids and Increase Substrate Affinity." J. Biol. Chem. 2012. 287(50):41619-41627.

Academic Affiliations & Courses

Graduate Program Affiliation

Graduate Program in Biological Chemistry

Activities & Honors

Honors

  • Corresponding Member, Academy of Sciences of the Universita di Bologna, 2009

Memberships

  • American Chemical Society
  • American Society for Biochemistry and Molecular Biology
  • American Society for Cell Biology
  • The Biochemical Society

Professional Activities

  • Editorial advisor, The Biochemical Journal
  • Editorial board, The Journal of Biological Chemistry
  • Editor-in-Chief, Journal of Bioenergetics and Biomembranes
  • Founder and Director, Lipid Research Division of the American Society for Biochemistry and Molecular Biology
  • Review Panel, FIRB Italian Ministry of Education and Research
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