Dr. D. Brian Foster graduated from Queen's University in Kingston, Ontario, with a Ph.D. in biochemistry under Dr. Jennifer Van Eyk. He moved to Boston where he received an American Heart Association Postdoctoral Fellowship to study biophysics and biochemistry of the "stunned" heart. Dr. Foster came to The Johns Hopkins School of Medicine, Division of Cardiology seeking new opportunities to further advance his training in biochemistry. As a junior faculty Research Associate, he spent much of his time searching for the identity of the elusive MitoKATP
channel, whose activity wards off cell death by necrosis during and after a heart attack. It was at this time that Dr. Foster began to embrace the techniques and technologies of proteomics that ultimately led to the discovery mitoROMK - the strongest candidate yet for the pore-forming subunit MitoKATP
. In a parallel effort, Dr. Foster teamed up with Dr. Anthony Cammarato to conduct the first ever proteomic analysis of the cardiac tube of the fruit fly, Drosophila melanogaster
, which was hailed as a “Top 10 Advance" in 2011 by the Functional Genomics and Translational Biology Council of the American Heart Association.
As an Assistant Professor, in the Division of Cardiology, Brian continues to integrate the tools of protein biochemistry and proteomics. Core projects include further efforts to unravel the role of mitoROMK in cardioprotection. He is also investigating how networks of proteins and their post-translational modifications are perturbed in cardiomyopathy and heart failure.