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D. Brian Foster, M.Sc., Ph.D.

Darren Brian Foster, M.Sc., Ph.D.

Photo of Dr. D. Brian Foster, M.Sc., Ph.D.

Director, Laboratory of Cardiovascular Biochemistry

Assistant Professor of Medicine

Research Interests: Cardiomyopathy; Heart Failure; Preconditioning

Contact for Research Inquiries

The Johns Hopkins University School of Medicine
Ross Research Building
720 Rutland Avenue
Baltimore, MD 21205 map
Phone: 410-614-0027

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Background

Dr. D. Brian Foster graduated from Queen's University in Kingston, Ontario, with a Ph.D. in biochemistry under Dr. Jennifer Van Eyk. He moved to Boston where he received an American Heart Association Postdoctoral Fellowship to study biophysics and biochemistry of the "stunned" heart. Dr. Foster came to The Johns Hopkins School of Medicine, Division of Cardiology seeking new opportunities to further advance his training in biochemistry. As a junior faculty Research Associate, he spent much of his time searching for the identity of the elusive MitoKATP channel, whose activity wards off cell death by necrosis during and after a heart attack. It was at this time that Dr. Foster began to embrace the techniques and technologies of proteomics that ultimately led to the discovery mitoROMK - the strongest candidate yet for the pore-forming subunit MitoKATP. In a parallel effort, Dr. Foster teamed up with Dr. Anthony Cammarato to conduct the first ever proteomic analysis of the cardiac tube of the fruit fly, Drosophila melanogaster, which was hailed as a “Top 10 Advance" in 2011 by the Functional Genomics and Translational Biology Council of the American Heart Association.

As an Assistant Professor, in the Division of Cardiology, Brian continues to integrate the tools of protein biochemistry and proteomics. Core projects include further efforts to unravel the role of mitoROMK in cardioprotection. He is also investigating how networks of proteins and their post-translational modifications are perturbed in cardiomyopathy and heart failure.
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Titles

  • Director, Laboratory of Cardiovascular Biochemistry
  • Assistant Professor of Medicine

Departments / Divisions

Centers & Institutes

Education

Degrees

  • B.Sc., Queen's University (Canada) (1993)
  • M.Sc., Queen's University (Canada) (1997)
  • Ph.D., Queen's University (Canada) (2001)

Research & Publications

Research Summary

The Foster Lab uses the tools of protein biochemistry & proteomics to tackle fundamental problems in cardiac preconditioning, cardiomyopathy and heart failure. 

Lab Website: Foster Lab

Technology Expertise Keywords

Protein Biochemistry, Proteomics

Activities & Honors

Memberships

  • American Heart Association
  • Biophysical Society
  • US HUPO
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