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Richard A.E. Edden, M.Sc., Ph.D.

Photo of Dr. Richard A.E. Edden, M.Sc., Ph.D.

Associate Professor of Radiology and Radiological Science

Research Interests: In vivo magnetic resonance spectroscopy (MRS)

Background

Dr. Richard Edden is an Associate Professor in the Johns Hopkins Medicine Department of Radiology and Radiological Science. His research focuses on the development of new magnetic resonance spectroscopy (MRS) methods and the application of existing methods to investigate the brain.

Dr. Edden received his undergraduate and graduate degree in the chemistry from the University of Cambridge as a scholar of Selwyn College. He completed a fellowship at the Schools of Biosciences and Chemistry at Cardiff University in Wales.

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Titles

  • Associate Professor of Radiology and Radiological Science

Education

Degrees

  • M.Sc., University of Cambridge (United Kingdom) (2001)
  • Ph.D., University of Cambridge (United Kingdom) (2005)

Additional Training

Cardiff University, Cardiff, Wales, United Kingdom, 2009, Fellowship

Research & Publications

Research Summary

Dr. Edden’s research is concerned with both the development of new MRS methods and the application of existing methods to investigate the brain. One technical area of his research relates to the behavior of coupled spin systems (such as lactate, citrate, GABA, and Glx) during localized spectroscopy experiments. Specifically, he investigates the interplay between finite-bandwidth slice-selective pulses and the chemical shift difference between coupled spins.

Clinical Trial Keywords

Restless leg syndrome

Clinical Trials

Glutamate, Hyperarousal and Restless Legs Syndrome

Selected Publications

1. Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA. Mullins PG, McGonigle DJ, O'Gorman RL, Puts NA, Vidyasagar R, Evans CJ; Cardiff Symposium on MRS of GABA, Edden RA. Neuroimage. 2014 Feb 1;86:43-52.
2. Reduced GABA concentration in attention-deficit/hyperactivity disorder. Edden RA, Crocetti D, Zhu H, Gilbert DL, Mostofsky SH. Arch Gen Psychiatry. 2012 Jul;69(7):750-3.
3. Regionally specific human GABA concentration correlates with tactile discrimination thresholds. Puts NA, Edden RA, Evans CJ, McGlone F, McGonigle DJ. J Neurosci. 2011 Nov 16;31(46):16556-60.
4. More GABA, less distraction: a neurochemical predictor of motor decision speed. Sumner P, Edden RA, Bompas A, Evans CJ, Singh KD. Nat Neurosci. 2010 Jul;13(7):825-7.
5. Resting GABA concentration predicts peak gamma frequency and fMRI amplitude in response to visual stimulation in humans. Muthukumaraswamy SD, Edden RA, Jones DK, Swettenham JB, Singh KD. Proc Natl Acad Sci U S A. 2009 May 19;106(20):8356-61.
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